E-Bibliothek Gesundheitskompetenz des DNGK
Autorinnenseite: Michaela Eikermann (Mitglied des DNGK)
Hier finden Sie die in der Datenbank des DNGK eingestellten Publikationen des genannten DNGK-Mitglieds.
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10149
https://gesundheitskompetenz.online/wp-content/plugins/zotpress/
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Mathes, Tim, Peggy Prien, Irma Klerings, Hannah Ewald, Corinna Dressler, Thomas Harder, Fülöp Scheibler, et al. "Guidance on how to efficiently find, choose, and use available systematic reviews was developed." Journal of Clinical Epidemiology 173 (September 1, 2024). https://doi.org/10.1016/j.jclinepi.2024.111466.
Becker, Monika, Ute Hansen, and Michaela Eikermann. "Stehen die Bewertungen von Individuellen Gesundheitsleistungen (IGeL) des IGeL-Monitors im Einklang mit Leitlinien?" Das Gesundheitswesen 85, no. 12 (December 2023): 1192–99. https://doi.org/10.1055/a-2158-8869.
Eikermann, Michaela. "Bewertung individueller Gesundheitsleistungen im IGeL-Monitor." KVH-Jourmal, no. 12 (2022): 22–25.
Mathes, Tim, Dawid Pieper, Johannes Morche, Stephanie Polus, Thomas Jaschinski, and Michaela Eikermann. “Pay for Performance for Hospitals.” The Cochrane Database of Systematic Reviews 7 (July 5, 2019): CD011156. https://doi.org/10.1002/14651858.CD011156.pub2.
Prengel, Peggy, Nina Kotte, Sunya-Lee Antoine, Michaela Eikermann, Edmund A. M. Neugebauer, Katja Stahl, and Dawid Pieper. “Patienten zeigen sich zufrieden mit der Arzt-Patienten-Kommunikation – eine Pilotstudie mit dem „Individual Clinician Feedback“- Fragebogen.” Gesundheitswesen (Bundesverband Der Arzte Des Offentlichen Gesundheitsdienstes (Germany)) 80, no. 10 (October 2018): 882–87. https://doi.org/10.1055/s-0043-104690.
Polytrauma Guideline Update Group. “Level 3 Guideline on the Treatment of Patients with Severe/Multiple Injuries : AWMF Register-Nr. 012/019.” European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society 44, no. Suppl 1 (April 2018): 3–271. https://doi.org/10.1007/s00068-018-0922-y.
Jaschinski, Thomas, Christoph G. Mosch, Michaela Eikermann, Edmund Am Neugebauer, and Stefan Sauerland. “Laparoscopic versus Open Surgery for Suspected Appendicitis.” The Cochrane Database of Systematic Reviews 11 (28 2018): CD001546. https://doi.org/10.1002/14651858.CD001546.pub4.
Becker, Monika, Thomas Jaschinski, Michaela Eikermann, Tim Mathes, Stefanie Bühn, Wolfgang Koppert, Andreas Leffler, Edmund Neugebauer, and Dawid Pieper. “A Systematic Decision-Making Process on the Need for Updating Clinical Practice Guidelines Proved to Be Feasible in a Pilot Study.” Journal of Clinical Epidemiology 96 (2018): 101–9. https://doi.org/10.1016/j.jclinepi.2017.12.011.
Hoffmann-Eßer, Wiebke, Ulrich Siering, Edmund A. M. Neugebauer, Ulrike Lampert, and Michaela Eikermann. “Systematic Review of Current Guideline Appraisals Performed with the Appraisal of Guidelines for Research & Evaluation II Instrument-a Third of AGREE II Users Apply a Cut-off for Guideline Quality.” Journal of Clinical Epidemiology 95 (2018): 120–27. https://doi.org/10.1016/j.jclinepi.2017.12.009.
Hoffmann-Eßer, Wiebke, Ulrich Siering, Edmund A. M. Neugebauer, Anne Catharina Brockhaus, Natalie McGauran, and Michaela Eikermann. “Guideline Appraisal with AGREE II: Online Survey of the Potential Influence of AGREE II Items on Overall Assessment of Guideline Quality and Recommendation for Use.” BMC Health Services Research 18, no. 1 (27 2018): 143. https://doi.org/10.1186/s12913-018-2954-8.
Rath, Ana, Valérie Salamon, Sandra Peixoto, Virginie Hivert, Martine Laville, Berenice Segrestin, Edmund A. M. Neugebauer, et al. “A Systematic Literature Review of Evidence-Based Clinical Practice for Rare Diseases: What Are the Perceived and Real Barriers for Improving the Evidence and How Can They Be Overcome?” Trials 18, no. 1 (November 22, 2017): 556. https://doi.org/10.1186/s13063-017-2287-7.
Jacobs, Esther, Sunya-Lee Antoine, Barbara Prediger, Edmund Neugebauer, and Michaela Eikermann. “DEFINING THE RELEVANT OUTCOME MEASURES IN MEDICAL DEVICE ASSESSMENTS: AN ANALYSIS OF THE DEFINITION PROCESS IN HEALTH TECHNOLOGY ASSESSMENT.” International Journal of Technology Assessment in Health Care 33, no. 1 (January 2017): 84–92. https://doi.org/10.1017/S0266462317000216.
Neugebauer, Edmund A. M., Ana Rath, Sunya-Lee Antoine, Michaela Eikermann, Doerthe Seidel, Carsten Koenen, Esther Jacobs, et al. “Specific Barriers to the Conduct of Randomised Clinical Trials on Medical Devices.” Trials 18, no. 1 (13 2017): 427. https://doi.org/10.1186/s13063-017-2168-0.
PICK, PETER, and MICHAELA EIKERMANN. "5 Jahre IGeL-Monitor: Eine erste Bilanz." Gesundheits- und Sozialpolitik 71, no. 2 (2017): 33–38.
Hoffmann-Eßer, Wiebke, Ulrich Siering, Edmund A. M. Neugebauer, Anne Catharina Brockhaus, Ulrike Lampert, and Michaela Eikermann. “Guideline Appraisal with AGREE II: Systematic Review of the Current Evidence on How Users Handle the 2 Overall Assessments.” PloS One 12, no. 3 (2017): e0174831. https://doi.org/10.1371/journal.pone.0174831.
Garattini, Silvio, Janus C. Jakobsen, Jørn Wetterslev, Vittorio Bertelé, Rita Banzi, Ana Rath, Edmund A. M. Neugebauer, et al. “Evidence-Based Clinical Practice: Overview of Threats to the Validity of Evidence and How to Minimise Them.” European Journal of Internal Medicine 32 (July 2016): 13–21. https://doi.org/10.1016/j.ejim.2016.03.020.
Marx, Gernot, Achim W. Schindler, Christoph Mosch, Joerg Albers, Michael Bauer, Irmela Gnass, Carsten Hobohm, et al. “Intravascular Volume Therapy in Adults: Guidelines from the Association of the Scientific Medical Societies in Germany.” European Journal of Anaesthesiology 33, no. 7 (July 2016): 488–521. https://doi.org/10.1097/EJA.0000000000000447.
Pieper, Dawid, Fabian Jülich, Sunya-Lee Antoine, Christina Bächle, Nadja Chernyak, Jutta Genz, Michaela Eikermann, and Andrea Icks. “Studies Analysing the Need for Health-Related Information in Germany - a Systematic Review.” BMC Health Services Research 15 (September 23, 2015): 407. https://doi.org/10.1186/s12913-015-1076-9.
Pieper, Dawid, Roland Brian Buechter, Lun Li, Barbara Prediger, and Michaela Eikermann. “Systematic Review Found AMSTAR, but Not R(Evised)-AMSTAR, to Have Good Measurement Properties.” Journal of Clinical Epidemiology 68, no. 5 (May 2015): 574–83. https://doi.org/10.1016/j.jclinepi.2014.12.009.
Pieper, Dawid, Sunya-Lee Antoine, Edmund A. M. Neugebauer, and Michaela Eikermann. “Up-to-Dateness of Reviews Is Often Neglected in Overviews: A Systematic Review.” Journal of Clinical Epidemiology 67, no. 12 (December 2014): 1302–8. https://doi.org/10.1016/j.jclinepi.2014.08.008.
Eikermann, Michaela, Nicole Holzmann, Ulrich Siering, and Alric Rüther. “Tools for Assessing the Content of Guidelines Are Needed to Enable Their Effective Use--a Systematic Comparison.” BMC Research Notes 7 (November 26, 2014): 853. https://doi.org/10.1186/1756-0500-7-853.
Pieper, Dawid, Sunya-Lee Antoine, Jana-Carina Morfeld, Tim Mathes, and Michaela Eikermann. “Methodological Approaches in Conducting Overviews: Current State in HTA Agencies.” Research Synthesis Methods 5, no. 3 (September 2014): 187–99. https://doi.org/10.1002/jrsm.1107.
Antoine, Sunya-Lee, Dawid Pieper, Tim Mathes, and Michaela Eikermann. “Improving the Adherence of Type 2 Diabetes Mellitus Patients with Pharmacy Care: A Systematic Review of Randomized Controlled Trials.” BMC Endocrine Disorders 14 (July 7, 2014): 53. https://doi.org/10.1186/1472-6823-14-53.
Mathes, Tim, Dawid Pieper, Sunya-Lee Antoine, and Michaela Eikermann. “Adherence Influencing Factors in Patients Taking Oral Anticancer Agents: A Systematic Review.” Cancer Epidemiology 38, no. 3 (June 2014): 214–26. https://doi.org/10.1016/j.canep.2014.03.012.
Mathes, Tim, Sunya-Lee Antoine, Dawid Pieper, and Michaela Eikermann. “Adherence Enhancing Interventions for Oral Anticancer Agents: A Systematic Review.” Cancer Treatment Reviews 40, no. 1 (February 2014): 102–8. https://doi.org/10.1016/j.ctrv.2013.07.004.
Becker, Monika, Edmund A. M. Neugebauer, and Michaela Eikermann. “Partial Updating of Clinical Practice Guidelines Often Makes More Sense than Full Updating: A Systematic Review on Methods and the Development of an Updating Procedure.” Journal of Clinical Epidemiology 67, no. 1 (January 2014): 33–45. https://doi.org/10.1016/j.jclinepi.2013.06.021.
Mathes, Tim, Maren Walgenbach, Sunya-Lee Antoine, Dawid Pieper, and Michaela Eikermann. “Methods for Systematic Reviews of Health Economic Evaluations: A Systematic Review, Comparison, and Synthesis of Method Literature.” Medical Decision Making: An International Journal of the Society for Medical Decision Making 34, no. 7 (2014): 826–40. https://doi.org/10.1177/0272989X14526470.
Mathes, Tim, Dawid Pieper, Sunya-Lee Antoine, and Michaela Eikermann. “Cost-Effectiveness of Adherence Interventions for Highly Active Antiretroviral Therapy: A Systematic Review.” International Journal of Technology Assessment in Health Care 29, no. 3 (July 2013): 227–33. https://doi.org/10.1017/S0266462313000317.
Pieper, Dawid, Tim Mathes, Edmund Neugebauer, and Michaela Eikermann. “State of Evidence on the Relationship between High-Volume Hospitals and Outcomes in Surgery: A Systematic Review of Systematic Reviews.” Journal of the American College of Surgeons 216, no. 5 (May 2013): 1015-1025.e18. https://doi.org/10.1016/j.jamcollsurg.2012.12.049.
Siering, Ulrich, Michaela Eikermann, Elke Hausner, Wiebke Hoffmann-Eßer, and Edmund A. Neugebauer. “Appraisal Tools for Clinical Practice Guidelines: A Systematic Review.” PloS One 8, no. 12 (2013): e82915. https://doi.org/10.1371/journal.pone.0082915.
Pieper, Dawid, Roland Buechter, Petra Jerinic, and Michaela Eikermann. “Overviews of Reviews Often Have Limited Rigor: A Systematic Review.” Journal of Clinical Epidemiology 65, no. 12 (December 2012): 1267–73. https://doi.org/10.1016/j.jclinepi.2012.06.015.
Mathes, Tim, Dawid Pieper, Sunya-Lee Antoine, and Michaela Eikermann. “50% Adherence of Patients Suffering Chronic Conditions--Where Is the Evidence?” German Medical Science: GMS e-Journal 10 (2012): Doc16. https://doi.org/10.3205/000167.
