E-Bibliothek Gesundheitskompetenz des DNGK
Autorenseite: Norbert Donner-Banzhoff (Mitglied des DNGK)
Hier finden Sie die in der Datenbank des DNGK eingestellten Publikationen des genannten DNGK-Mitglieds.
6298796
R2J5Y2I9
1
chicago-fullnote-bibliography
50
date
title
10210
https://gesundheitskompetenz.online/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A150%2C%22request_next%22%3A50%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22TLW67EUT%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Lindner%20et%20al.%22%2C%22parsedDate%22%3A%222025-07-08%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BLindner%2C%20Nicole%2C%20Marie-Christine%20Hoffmann%2C%20J%5Cu00f6rg%20Haasenritter%2C%20Jan%20K.%20Woike%2C%20and%20Norbert%20Donner-Banzhoff.%20%26quot%3B%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fbmcfampract.biomedcentral.com%5C%2Farticles%5C%2F10.1186%5C%2Fs12875-025-02887-x%26%23039%3B%26gt%3BAssessing%20physicians%26%23039%3B%20agreement%20and%20the%20completeness%20of%20the%20decision%20aid%20%26%23039%3Barriba%20Diabetes%26%23039%3B%3A%20a%20cross-sectional%20study%26lt%3B%5C%2Fa%26gt%3B.%26quot%3B%20%26lt%3Bi%26gt%3BBMC%20Primary%20Care%26lt%3B%5C%2Fi%26gt%3B%2026%2C%20no.%201%20%28July%208%2C%202025%29%3A%20218.%20https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12875-025-02887-x.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Assessing%20physicians%27%20agreement%20and%20the%20completeness%20of%20the%20decision%20aid%20%27arriba%20Diabetes%27%3A%20a%20cross-sectional%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22Lindner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie-Christine%22%2C%22lastName%22%3A%22Hoffmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00f6rg%22%2C%22lastName%22%3A%22Haasenritter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jan%20K.%22%2C%22lastName%22%3A%22Woike%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Background%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Guidelines%20for%20type%202%20diabetes%20emphasise%20individualised%20treatment%20goals%2C%20yet%20implementation%20remains%20challenging%20in%20primary%20care.%20To%20address%20this%2C%20we%20developed%20the%20%5Cu201carriba%20Diabetes%5Cu201d%20software%2C%20a%20patient-centred%20decision%20support%20tool.%20The%20software%20provides%20individualised%20recommendations%20for%20intensity%20of%20treatment%20based%20on%20four%20inputs%3A%20age%2C%20comorbidities%2C%20treatment%20burden%20preference%2C%20and%20risk%20reduction%20preference.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20In%20a%20cross-sectional%20evaluation%20study%20in%20German%20primary%20care%2C%20we%20included%2034%20general%20practitioners%20%28GPs%29%20and%20152%20patients.%20The%20primary%20aim%20of%20this%20study%20was%20to%20evaluate%20the%20%5Cu201carriba%20Diabetes%5Cu201d%20software%20by%20assessing%20the%20agreement%20between%20its%20treatment%20intensity%20recommendation%20and%20physicians%5Cu2019%20clinical%20judgement.%20Additionally%2C%20we%20explored%20the%20cases%20of%20disagreement%2C%20the%20distribution%20of%20patient-specific%20inputs%20and%20physicians%5Cu2019%20perspectives%20on%20the%20software%5Cu2019s%20usability.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20%5Cu201carriba%20Diabetes%5Cu201d%20recommendations%20aligned%20in%2087%25%20of%20cases%20with%20GPs%5Cu2019%20recommendation%2C%20and%2087%25%20of%20the%20doctors%20would%20use%20%5Cu201carriba%20Diabetes%5Cu201d%20in%20the%20future.%20Patients%20had%20a%20median%20age%20of%2068%20years%20with%20a%20low%20comorbid%20load%20%28median%203%20on%20a%20scale%200%5Cu201310%29.%20Patients%20expressed%20a%20moderate%20preference%20for%20higher%20treatment%20burden%20%28median%206%20on%20a%20scale%200%5Cu201310%29%20and%20a%20high%20preference%20to%20reduce%20organ%20complications%20in%20the%20future%20%28median%208%20on%20a%20scale%200%5Cu201310%29.%20Acceptance%20of%20therapy%20burden%20correlated%20positively%20with%20the%20preference%20to%20reduce%20organ%20damage%20%28Spearman%20correlation%20coefficient%3A%20%2B0.49%29.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusions%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Recommendations%20of%20%5Cu201carriba%20Diabetes%5Cu201d%20were%20well%20aligned%20with%20GPs%5Cu2019%20recommendations.%20Implementation%20of%20the%20%5Cu201carriba%20Diabetes%5Cu201d%20software%20has%20the%20potential%20to%20promote%20patient-centred%20and%20evidence-based%20diabetes%20treatment%20decisions%20in%20primary%20care.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Graphical%20Abstract%22%2C%22date%22%3A%222025-07-08%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12875-025-02887-x%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fbmcfampract.biomedcentral.com%5C%2Farticles%5C%2F10.1186%5C%2Fs12875-025-02887-x%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222731-4553%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22R2J5Y2I9%22%2C%22NGZ4ME9D%22%5D%2C%22dateModified%22%3A%222025-11-16T08%3A38%3A57Z%22%7D%7D%2C%7B%22key%22%3A%22KNBG3PWX%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kornder%20et%20al.%22%2C%22parsedDate%22%3A%222025-05-27%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BKornder%2C%20Nele%2C%20Norbert%20Donner-Banzhoff%2C%20Ina%20Staudt%2C%20Nina%20Grede%2C%20Annette%20Becker%2C%20and%20Annika%20Viniol.%20%26quot%3B%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fbmcmedresmethodol.biomedcentral.com%5C%2Farticles%5C%2F10.1186%5C%2Fs12874-025-02597-z%26%23039%3B%26gt%3BTrials%20evaluating%20drug%20discontinuation%3A%20a%20scoping%20review%20sub-analysis%20focusing%20on%20outcomes%20and%20research%20questions%26lt%3B%5C%2Fa%26gt%3B.%26quot%3B%20%26lt%3Bi%26gt%3BBMC%20Medical%20Research%20Methodology%26lt%3B%5C%2Fi%26gt%3B%2025%2C%20no.%201%20%28May%2027%2C%202025%29%3A%20146.%20https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12874-025-02597-z.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Trials%20evaluating%20drug%20discontinuation%3A%20a%20scoping%20review%20sub-analysis%20focusing%20on%20outcomes%20and%20research%20questions%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nele%22%2C%22lastName%22%3A%22Kornder%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ina%22%2C%22lastName%22%3A%22Staudt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nina%22%2C%22lastName%22%3A%22Grede%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Becker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annika%22%2C%22lastName%22%3A%22Viniol%22%7D%5D%2C%22abstractNote%22%3A%22Abstract%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Background%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20widespread%20use%20of%20long-term%20pharmacological%20treatments%20for%20chronic%20conditions%20has%20led%20to%20polypharmacy%2C%20raising%20concerns%20about%20adverse%20effects%20and%20interactions.%20Deprescribing%2C%20the%20discontinuation%20of%20drugs%20with%20unfavorable%20benefit-risk%20ratios%2C%20is%20gaining%20attention.%20Studies%20evaluating%20the%20discontinuation%20of%20drugs%20have%20a%20broad%20methodological%20spectrum.%20The%20selection%20of%20outcomes%20poses%20a%20particular%20challenge.%20This%20scoping%20review%20addresses%20the%20methodological%20challenges%20of%20outcome%20selection%20in%20RCTs%20investigating%20drug%20discontinuation.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20scoping%20review%20includes%20RCTs%20that%20investigated%20the%20discontinuation%20of%20drugs%20whose%20efficacy%20and%5C%2For%20safety%20was%20in%20doubt.%20Data%20on%20study%20characteristics%2C%20the%20motivation%20for%20evaluating%20drug%20discontinuation%2C%20the%20number%20and%20type%20of%20primary%20endpoints%2C%20and%20the%20stated%20hypotheses%20were%20extracted%20and%20analyzed.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20We%20included%20103%20RCTs.%20Most%20studies%20were%20from%20Europe%20and%20the%20USA%20and%20mainly%20investigated%20antipsychotics%5C%2Fantidepressants%2C%20immunosuppressants%2C%20steroids%20and%20antiepileptics.%20The%20discontinuation%20studies%20were%20often%20conducted%20due%20to%20side%20effects%20of%20the%20treatment%20and%20doubts%20about%20the%20benefits%20of%20the%20drug.%20The%20primary%20endpoints%20reflected%20either%20the%20course%20of%20the%20disease%20%28%26quot%3Bjustification%20of%20treatment%26quot%3B%29%20or%20the%20disadvantages%20of%20the%20drug%20%28%26quot%3Bjustification%20of%20withdrawal%5Cu201d%29.%20Non-inferiority%20hypotheses%20were%20generally%20prevalent%20in%20justification%20of%20treatment%20studies%2C%20while%20superiority%20hypotheses%20were%20more%20commonly%20used%20in%20justification%20of%20withdrawal%20studies.%20However%2C%20due%20to%20methodological%20and%20practical%20challenges%20this%20was%20not%20always%20the%20case.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusion%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20We%20present%20a%20framework%20to%20choose%20outcomes%20and%20specify%20hypotheses%20for%20discontinuation%20studies.%20With%20regard%20to%20this%2C%20both%20key%20challenges%20%28justification%20of%20treatment%20and%20justification%20of%20withdrawal%29%20must%20be%20met.%22%2C%22date%22%3A%222025-05-27%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12874-025-02597-z%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fbmcmedresmethodol.biomedcentral.com%5C%2Farticles%5C%2F10.1186%5C%2Fs12874-025-02597-z%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221471-2288%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22R2J5Y2I9%22%2C%22NGZ4ME9D%22%5D%2C%22dateModified%22%3A%222025-11-16T08%3A40%3A32Z%22%7D%7D%2C%7B%22key%22%3A%22M6YC73JH%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Gollnick%20et%20al.%22%2C%22parsedDate%22%3A%222025-01-03%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGollnick%2C%20Julia%2C%20Nikoletta%20Zeschick%2C%20Franziska%20H%5Cu00f6rbrand%2C%20Peter%20Killian%2C%20Maria%20Sebastiao%2C%20Thomas%20K%5Cu00fchlein%2C%20and%20Norbert%20Donner-Banzhoff.%20%26quot%3B%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12913-024-12189-0%26%23039%3B%26gt%3BSurveillance%20of%20drug%20prescribing%3A%20why%20outliers%20miss%20their%20targets%20%5Cu2013%20a%20qualitative%20study%26lt%3B%5C%2Fa%26gt%3B.%26quot%3B%20%26lt%3Bi%26gt%3BBMC%20Health%20Services%20Research%26lt%3B%5C%2Fi%26gt%3B%2025%2C%20no.%201%20%28January%203%2C%202025%29%3A%2017.%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Surveillance%20of%20drug%20prescribing%3A%20why%20outliers%20miss%20their%20targets%20%5Cu2013%20a%20qualitative%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Gollnick%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nikoletta%22%2C%22lastName%22%3A%22Zeschick%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Franziska%22%2C%22lastName%22%3A%22H%5Cu00f6rbrand%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%22%2C%22lastName%22%3A%22Killian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%22%2C%22lastName%22%3A%22Sebastiao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22K%5Cu00fchlein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%5D%2C%22abstractNote%22%3A%22Rising%20costs%20are%20a%20challenge%20for%20healthcare%20systems.%20To%20keep%20expenditure%20for%20drugs%20under%20control%2C%20in%20many%20healthcare%20systems%2C%20drug%20prescribing%20is%20continuously%20monitored.%20The%20Bavarian%20Drug%20Agreement%20%28German%3A%20Wirkstoffvereinbarung%20or%20WSV%29%20for%20the%20ambulatory%20sector%20in%20Bavaria%20%28the%20federal%20state%20of%20Germany%29%20was%20developed%20for%20this%20purpose.%20Physicians%20must%20reach%20defined%20drug%20target%20quotas%20for%20prescribing%20generic%20drugs%20and%20certain%20recommended%20drugs%20specified%20and%20measured%20with%20defined%20daily%20doses%20%28DDD%29.%20A%20subgroup%20of%20physicians%2C%20known%20as%20outliers%2C%20may%20miss%20their%20drug%20targets.%20The%20objective%20of%20this%20qualitative%20study%20was%20to%20understand%20the%20reasons%20physicians%20miss%20their%20targets.%22%2C%22date%22%3A%222025-01-03%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12913-024-12189-0%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12913-024-12189-0%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221472-6963%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22EBMCDUNP%22%2C%22R2J5Y2I9%22%2C%22QXIGN3AI%22%5D%2C%22dateModified%22%3A%222025-04-09T10%3A03%3A21Z%22%7D%7D%2C%7B%22key%22%3A%22X99W7CRF%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Purkl%20et%20al.%22%2C%22parsedDate%22%3A%222025-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BPurkl%2C%20Laura%2C%20Konrad%20Hierasimowicz%2C%20and%20Norbert%20Donner-Banzhoff.%20%26%23x201C%3BThree%20Types%20of%20Uncertainty%3A%20A%20Qualitative%20Study%20of%20Family%20Medicine%20Residents.%26%23x201D%3B%20%26lt%3Bi%26gt%3BFamily%20Medicine%26lt%3B%5C%2Fi%26gt%3B%2057%2C%20no.%201%20%28January%202025%29%3A%209%26%23x2013%3B15.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.22454%5C%2FFamMed.2024.798978%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.22454%5C%2FFamMed.2024.798978%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Three%20Types%20of%20Uncertainty%3A%20A%20Qualitative%20Study%20of%20Family%20Medicine%20Residents%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%22%2C%22lastName%22%3A%22Purkl%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Konrad%22%2C%22lastName%22%3A%22Hierasimowicz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%20AND%20OBJECTIVES%3A%20Many%20past%20studies%20have%20focused%20on%20uncertainty%20in%20medical%20practice%2C%20yet%20it%20is%20still%20not%20well%20understood%20in%20the%20field%20of%20family%20medicine%2C%20especially%20among%20residents.%20The%20aim%20of%20this%20study%20was%20to%20examine%20situations%20in%20which%20residents%20experience%20uncertainty%20and%20the%20coping%20strategies%20they%20use%20to%20deal%20with%20it.%20The%20results%20may%20have%20implications%20for%20advanced%20training%20programs%20and%20the%20specialist%20training%20in%20family%20medicine.%5CnMETHODS%3A%20We%20conducted%20semistandardized%20interviews%20with%2015%20residents%20and%20young%20family%20doctors%20from%20Hesse%2C%20Germany%20and%20asked%20them%20to%20describe%20cases%20in%20which%20they%20experienced%20uncertainty.%20In%20total%2C%2040%20cases%20were%20reported.%20Using%20established%20methods%2C%20we%20derived%20a%20coding%20system%20with%20different%20categories.%5CnRESULTS%3A%20Uncertainty%20occurred%20in%20a%20broad%20and%20heterogenous%20range%20of%20cases%2C%20and%20it%20often%20involved%20complex%20interaction%20of%20biomedical%2C%20interpersonal%2C%20and%20psychosocial%20factors.%20The%20participants%20described%20various%20strategies%20that%20were%20helpful%20in%20dealing%20with%20the%20three%20different%20types%20of%20uncertainty.%20To%20deal%20with%20biomedical%20uncertainty%2C%20the%20residents%20primarily%20found%20information-seeking%20and%20consulting%20more%20experienced%20colleagues%20to%20be%20useful.%20In%20dealing%20with%20interpersonal%20and%20psychosocial%20uncertainty%2C%20they%20applied%20reflective%20strategies.%20Participants%20suggested%20open%20communication%20and%20honest%20dialogue%20about%20uncertainty%20and%20the%20thematization%20of%20the%20topic%20at%20much%20earlier%20stages%20%28eg%2C%20during%20medical%20studies%29.%5CnCONCLUSIONS%3A%20Family%20medicine%20residents%20experience%20uncertainty%20as%20an%20important%20part%20of%20their%20daily%20work.%20They%20do%20not%20necessarily%20interpret%20it%20as%20a%20negative%20phenomenon.%20Instead%2C%20uncertain%20situations%20often%20accompany%20learning%20effectiveness%20and%20an%20increase%20of%20self-confidence.%22%2C%22date%22%3A%222025-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.22454%5C%2FFamMed.2024.798978%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221938-3800%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22EBMCDUNP%22%2C%22R2J5Y2I9%22%5D%2C%22dateModified%22%3A%222025-04-09T10%3A05%3A26Z%22%7D%7D%2C%7B%22key%22%3A%22G9K4M38R%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Prinz%20et%20al.%22%2C%22parsedDate%22%3A%222025%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BPrinz%2C%20Alicia%2C%20Sabrina%20Hoppe%2C%20Verena%20Leve%2C%20Rik%20Crutzen%2C%20Norbert%20Donner-Banzhoff%2C%20Stefan%20Wilm%2C%20and%20Sabrina%20Kastaun.%20%26quot%3B%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Ffmch.bmj.com%5C%2Flookup%5C%2Fdoi%5C%2F10.1136%5C%2Ffmch-2024-003124%26%23039%3B%26gt%3BExperiences%2C%20perceptions%20and%20attitudes%20on%20providing%20advice%20on%20physical%20activity%20to%20patients%20with%20chronic%20ischaemic%20heart%20disease%3A%20a%20qualitative%20study%20in%20general%20practitioners%20in%20Germany%26lt%3B%5C%2Fa%26gt%3B.%26quot%3B%20%26lt%3Bi%26gt%3BFamily%20Medicine%20and%20Community%20Health%26lt%3B%5C%2Fi%26gt%3B%2013%2C%20no.%203%20%282025%29%3A%20e003124.%20https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Ffmch-2024-003124.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Experiences%2C%20perceptions%20and%20attitudes%20on%20providing%20advice%20on%20physical%20activity%20to%20patients%20with%20chronic%20ischaemic%20heart%20disease%3A%20a%20qualitative%20study%20in%20general%20practitioners%20in%20Germany%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alicia%22%2C%22lastName%22%3A%22Prinz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabrina%22%2C%22lastName%22%3A%22Hoppe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Verena%22%2C%22lastName%22%3A%22Leve%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rik%22%2C%22lastName%22%3A%22Crutzen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Wilm%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabrina%22%2C%22lastName%22%3A%22Kastaun%22%7D%5D%2C%22abstractNote%22%3A%22Background%20and%20objective%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20WHO%20emphasises%20the%20importance%20of%20integrating%20advice%20on%20physical%20activity%20%28PA%29%20into%20primary%20care%20of%20patients%20with%20chronic%20ischaemic%20heart%20disease%20%28IHD%29.%20Similarly%2C%20the%20German%20treatment%20guideline%20%5Cu2018Chronic%20Coronary%20Heart%20Disease%5Cu2019%20recommends%20that%20general%20practitioners%20%28GPs%29%20provide%20advice%20on%20PA%20to%20IHD%20patients.%20However%2C%20the%20provision%20of%20PA%20advice%20seems%20to%20be%20inadequately%20implemented%20in%20general%20practice.%20One%20reason%20is%20the%20lack%20of%20medical%20training%20in%20providing%20PA%20advice%20effectively%20and%20efficiently.%20International%20guidelines%20recommend%20such%20training%20for%20health%20professionals.%20This%20study%20aims%20to%20explore%20experiences%2C%20perceptions%20and%20attitudes%2C%20including%20barriers%20and%20facilitators%20of%20GPs%20towards%20the%20routine%20delivery%20of%20PA%20advice%20to%20IHD%20patients.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Between%20March%20and%20June%202023%2C%2012%20face-to-face%20problem-centred%20interviews%20and%20six%20focus%20group%20discussions%20%28n%3D37%29%20with%20GPs%20were%20conducted.%20Interview%20and%20discussion%20guides%20were%20developed%20and%20pilot%20tested%20by%20the%20multi-professional%20study%20team.%20We%20used%20a%20purposive%20sampling%20strategy%2C%20and%20data%20were%20collected%20in%20an%20iterative%20process.%20Audio-recorded%20data%20were%20transcribed%20verbatim%20and%20analysed%20using%20a%20content%20structuring%20procedure%20%28deductive%20and%20inductive%20approach%29.%20GPs%20were%20involved%20throughout%20the%20entire%20research%20process%2C%20for%20example%2C%20in%20multi-professional%20analysis%20groups.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Although%20GPs%20are%20mostly%20aware%20of%20the%20health%20benefits%20of%20PA%20for%20patients%20with%20IHD%2C%20PA%20advice%20is%20not%20routinely%20provided.%20Conversations%20on%20PA%20tend%20to%20be%20rather%20unstructured%2C%20and%20advice%20is%20often%20addressed%20more%20generally%20than%20customised%20to%20the%20patients%5Cu2019%20needs%20and%20preferences.%20Priority%20is%20given%20to%20other%20lifestyle%20issues%2C%20such%20as%20smoking%20cessation.%20PA%20advice%20is%20perceived%20as%20time-consuming%20and%20rather%20ineffective%20with%20regard%20to%20the%20target%20behaviour.%20GPs%20frequently%20express%20frustration%20in%20this%20context.%20GPs%20express%20a%20lack%20of%20and%20simultaneously%20a%20need%20for%20communication%20strategies%20%28structure%20and%20tools%29%20that%20can%20be%20integrated%20into%20everyday%20GP%20practice%20to%20motivate%20patients%20to%20PA.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusion%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20The%20results%20provide%20relevant%20insights%20into%20the%20current%20practice%20of%20GPs%20with%20regard%20to%20their%20attitudes%20on%2C%20experiences%20with%2C%20and%20requirements%20for%20the%20provision%20of%20PA%20advice%20to%20IHD%20patients.%20These%20results%20are%20helpful%20to%20inform%20the%20development%20of%20appropriate%20GP%20training%20in%20the%20provision%20of%20very%20brief%20PA%20advice%20to%20IHD%20patients.%22%2C%22date%22%3A%2207%5C%2F2025%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1136%5C%2Ffmch-2024-003124%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Ffmch.bmj.com%5C%2Flookup%5C%2Fdoi%5C%2F10.1136%5C%2Ffmch-2024-003124%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222305-6983%2C%202009-8774%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22R2J5Y2I9%22%2C%22NGZ4ME9D%22%5D%2C%22dateModified%22%3A%222025-11-16T08%3A39%3A29Z%22%7D%7D%2C%7B%22key%22%3A%22TVYICRVA%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zeschick%20et%20al.%22%2C%22parsedDate%22%3A%222025%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BZeschick%2C%20Nikoletta%2C%20Julia%20Gollnick%2C%20Julia%20Muth%2C%20Franziska%20H%5Cu00f6rbrand%2C%20Peter%20Killian%2C%20Norbert%20Donner-Banzhoff%2C%20Thomas%20K%5Cu00fchlein%2C%20and%20Maria%20Sebasti%5Cu00e3o.%20%26quot%3B%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fjournals.sagepub.com%5C%2Fdoi%5C%2F10.1177%5C%2F11786329251341083%26%23039%3B%26gt%3BPrescribing%20Vitamin-K-Antagonists%20Versus%20Direct%20Oral%20Anticoagulants%20Among%20Bavarian%20General%20Practitioners%3A%20A%20Qualitative%20Study%26lt%3B%5C%2Fa%26gt%3B.%26quot%3B%20%26lt%3Bi%26gt%3BHealth%20Services%20Insights%26lt%3B%5C%2Fi%26gt%3B%2018%20%282025%29%3A%2011786329251341083.%20https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1177%5C%2F11786329251341083.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Prescribing%20Vitamin-K-Antagonists%20Versus%20Direct%20Oral%20Anticoagulants%20Among%20Bavarian%20General%20Practitioners%3A%20A%20Qualitative%20Study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nikoletta%22%2C%22lastName%22%3A%22Zeschick%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Gollnick%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Muth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Franziska%22%2C%22lastName%22%3A%22H%5Cu00f6rbrand%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%22%2C%22lastName%22%3A%22Killian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22K%5Cu00fchlein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%22%2C%22lastName%22%3A%22Sebasti%5Cu00e3o%22%7D%5D%2C%22abstractNote%22%3A%22Background%3A%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Direct%20oral%20anticoagulants%20%28DOACs%29%20have%20been%20increasingly%20prescribed%20instead%20of%20vitamin-K-antagonists%20%28VKA%29%20although%20VKAs%20cost%20considerably%20less%20than%20DOACs.%20In%202014%2C%20a%20new%20system%20for%20drug%20expenditures%2C%20the%20Wirkstoffvereinbarung%20%28WSV%2C%20Active%20substance%20agreement%29%2C%20was%20implemented%20in%20Bavaria%2C%20Germany%20to%20control%20pharmaceutical%20expenditures%20transparently.%20Achieving%20the%20targets%20for%20the%20VKAs%20set%20by%20the%20WSV%20was%20difficult%20for%20general%20practitioners%20%28GPs%29.%20We%20explored%20the%20determinants%20of%20prescribing%20VKAs%20%28specifically%20phenprocoumon%29%20versus%20DOACs.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Methods%3A%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Qualitative%20interviews%20%28n%5Cu2009%3D%5Cu200918%29%20and%20two%20small%20group%20discussions%20%28n%5Cu2009%3D%5Cu200910%29%20were%20conducted%20with%20GPs.%20For%20the%20qualitative%20content%20analysis%2C%20we%20formed%20a%20system%20of%20categories%20based%20on%20the%20domains%20of%20the%20Theoretical%20Domains%20Framework%20%28TDF%29.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Results%3A%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Participants%20actively%20weighed%20various%20factors%20when%20deciding%20between%20prescribing%20phenprocoumon%20or%20DOACs.%20Costs%20played%20a%20subordinate%20role%20although%20all%20participants%20were%20aware%20that%20DOACs%20come%20at%20a%20higher%20cost%20than%20phenprocoumon.%20Trend%20reports%20served%20as%20a%20tool%20for%20GPs%20to%20assess%20their%20prescribing%20practices%2C%20however%20did%20not%20lead%20to%20a%20change%20in%20prescribing%20behaviour.%20The%20interviewees%20had%20a%20very%20heterogeneous%20view%20of%20safety%2C%20effect%2C%20and%20evidence%20of%20phenprocoumon%20or%20DOACs.%20The%20cooperation%20of%20the%20patients%20is%20crucial.%20Time%20is%20a%20significant%20challenge%20for%20participants%20when%20initiating%20patients%20on%20or%20switching%20them%20to%20phenprocoumon%2C%20which%20is%20especially%20problematic%20as%20all%20of%20the%20patients%20discharged%20from%20the%20hospital%20are%20put%20on%20DOACs.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Conclusions%3A%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20GPs%20are%20caught%20between%20economic%20requirements%2C%20patients%5Cu2019%20wishes%2C%20and%20good%20collegial%20cooperation%20when%20deciding%20for%20or%20against%20phenprocoumon.%20As%20oral%20anticoagulant%20therapy%20%28OAC%29%20is%20mostly%20initiated%20in%20the%20hospital%2C%20and%20as%20physicians%20almost%20exclusively%20prescribe%20DOACs%20there%2C%20participating%20GPs%20feel%20overchallenged%20in%20reaching%20the%20targets%20set%20by%20the%20WSV.%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Trial%20registration%20number%3A%5Cn%20%20%20%20%20%20%20%20%20%20%20%20%20%20Main%20ID%3A%20DRKS00019820%20%28German%20Register%20of%20Clinical%20Studies%20and%20World%20Health%20Organization%29.%22%2C%22date%22%3A%2206%5C%2F2025%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1177%5C%2F11786329251341083%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fjournals.sagepub.com%5C%2Fdoi%5C%2F10.1177%5C%2F11786329251341083%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221178-6329%2C%201178-6329%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22R2J5Y2I9%22%2C%22NGZ4ME9D%22%5D%2C%22dateModified%22%3A%222025-11-16T08%3A40%3A06Z%22%7D%7D%2C%7B%22key%22%3A%22R3EAL7Y4%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Gollnick%20et%20al.%22%2C%22parsedDate%22%3A%222024-09-03%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGollnick%2C%20Julia%2C%20Nikoletta%20Zeschick%2C%20Julia%20Muth%2C%20Franziska%20H%26%23xF6%3Brbrand%2C%20Kerstin%20Behnke%2C%20Peter%20Killian%2C%20Maria%20Sebastiao%2C%20Thomas%20K%26%23xFC%3Bhlein%2C%20and%20Norbert%20Donner-Banzhoff.%20%26%23x201C%3BControlling%20Prescribing%20through%20%26%23x2018%3BPreferred%20Drug%26%23x2019%3B%20Targets-The%20Bavarian%20Experience.%26%23x201D%3B%20%26lt%3Bi%26gt%3BInternational%20Journal%20of%20Environmental%20Research%20and%20Public%20Health%26lt%3B%5C%2Fi%26gt%3B%2021%2C%20no.%209%20%28September%203%2C%202024%29%3A%201174.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fijerph21091174%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fijerph21091174%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Controlling%20Prescribing%20through%20%5C%22Preferred%20Drug%5C%22%20Targets-The%20Bavarian%20Experience%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Gollnick%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nikoletta%22%2C%22lastName%22%3A%22Zeschick%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Muth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Franziska%22%2C%22lastName%22%3A%22H%5Cu00f6rbrand%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kerstin%22%2C%22lastName%22%3A%22Behnke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%22%2C%22lastName%22%3A%22Killian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%22%2C%22lastName%22%3A%22Sebastiao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22K%5Cu00fchlein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20The%20rising%20costs%20of%20drugs%20are%20putting%20health%20care%20systems%20under%20pressure.%20We%20report%20on%20the%20Bavarian%20Drug%20Agreement%2C%20which%20employs%20prescribing%20targets%20for%20preferred%20and%20generic%20drugs%20in%20ambulatory%20care.%20Under%20this%20agreement%2C%20providers%20are%20regularly%20profiled%20with%20individual%20feedback%20but%20also%20possible%20sanctions.%20We%20investigated%20the%20degree%20to%20which%20targets%20were%20being%20met%20%28or%20not%29%20and%20why%20failure%20occurred.%5CnMETHODS%3A%20We%20analysed%20prescribing%20data%20aggregated%20by%20practice%20for%20the%20quarter%201%5C%2F2018.%20We%20chose%20eight%20specialisation%20groups%20and%20analysed%20their%20drug%20targets%20with%20a%20high%20prescribing%20volume%2C%20widely%20missed%20drug%20targets%20%28%26lt%3B90%25%29%2C%20and%20drugs%20preventing%20drug%20target%20achievement.%20Characterisation%20of%20drug%20targets%20and%20preventing%20drugs%20was%20undertaken.%5CnRESULTS%3A%20Drug%20targets%20with%20a%20high%20prescribing%20volume%20are%20mostly%20achieved%2C%20while%20highly%20missed%20drug%20targets%20mostly%20do%20not%20affect%20the%20main%20indication%20area%20of%20the%20specialisation%20groups%20considered.%20Generic%20drug%20targets%20seem%20to%20be%20more%20easily%20achieved%20than%20recommended%20drug%20targets.%20Paediatrics%20accounts%20for%20the%20largest%20number%20of%20missed%20drug%20targets.%5CnCONCLUSIONS%3A%20The%20Bavarian%20tool%20implemented%20uses%20the%20prescribing%20volume%20%28DDD%29%20and%20price%20components%20to%20evaluate%20the%20prescription%20behaviour%20of%20physicians.%20Well-established%20drugs%20with%20demonstrated%20effectiveness%2C%20safety%2C%20and%20lower%20costs%20are%20preferred.%20Nevertheless%2C%20me-too%20drugs%2C%20combination%20drugs%2C%20costly%20innovations%20with%20unclear%20value%2C%20and%20drugs%20with%20application%20methods%20of%20variable%20convenience%20challenge%20the%20drug%20prescribers%20and%20are%20reasons%20for%20missed%20drug%20targets.%22%2C%22date%22%3A%222024-09-03%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.3390%5C%2Fijerph21091174%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221660-4601%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22EBMCDUNP%22%2C%22R2J5Y2I9%22%5D%2C%22dateModified%22%3A%222025-04-09T10%3A06%3A09Z%22%7D%7D%2C%7B%22key%22%3A%2245GEZDBB%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Jung-Henrich%20et%20al.%22%2C%22parsedDate%22%3A%222024-04-25%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BJung-Henrich%2C%20Jutta%2C%20Kathrin%20Schl%26%23xF6%3B%26%23xDF%3Bler%2C%20Til%20Uebel%2C%20Nino%20Chikhradze%2C%20Anastasia%20Suslow%2C%20Nicole%20Lindner%2C%20Sandra%20Fahrenkrog%2C%20et%20al.%20%26%23x201C%3BDevelopment%20and%20Implementation%20of%20a%20Treatment%20Pathway%20to%20Reduce%20Coronary%20Angiograms%20-%20Lessons%20from%20a%20Failure.%26%23x201D%3B%20%26lt%3Bi%26gt%3BBMC%20Health%20Services%20Research%26lt%3B%5C%2Fi%26gt%3B%2024%2C%20no.%201%20%28April%2025%2C%202024%29%3A%20527.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12913-024-10904-5%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12913-024-10904-5%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Development%20and%20implementation%20of%20a%20treatment%20pathway%20to%20reduce%20coronary%20angiograms%20-%20lessons%20from%20a%20failure%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jutta%22%2C%22lastName%22%3A%22Jung-Henrich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22Schl%5Cu00f6%5Cu00dfler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Til%22%2C%22lastName%22%3A%22Uebel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nino%22%2C%22lastName%22%3A%22Chikhradze%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anastasia%22%2C%22lastName%22%3A%22Suslow%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nicole%22%2C%22lastName%22%3A%22Lindner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandra%22%2C%22lastName%22%3A%22Fahrenkrog%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Judith%22%2C%22lastName%22%3A%22Kraft%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eva%22%2C%22lastName%22%3A%22Hummers%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Horst%20Christian%22%2C%22lastName%22%3A%22Vollmar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ildik%5Cu00f3%22%2C%22lastName%22%3A%22G%5Cu00e1gyor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dirk%22%2C%22lastName%22%3A%22Heider%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hans-Helmut%22%2C%22lastName%22%3A%22K%5Cu00f6nig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20The%20rates%20of%20coronary%20angiograms%20%28CA%29%20and%20related%20procedures%20%28percutaneous%20intervention%20%5BPCI%5D%29%20are%20significantly%20higher%20in%20Germany%20than%20in%20other%20Organisation%20for%20Economic%20Co-ordination%20and%20Development%20%28OECD%29%20countries.%20The%20current%20guidelines%20recommend%20non-invasive%20diagnosis%20of%20coronary%20heart%20disease%20%28CHD%29%3B%20CA%20should%20only%20have%20a%20limited%20role%20in%20choosing%20the%20appropriate%20revascularisation%20procedure.%20The%20aim%20of%20the%20present%20study%20was%20to%20explore%20whether%20improvements%20in%20guideline%20adherence%20can%20be%20achieved%20through%20the%20implementation%20of%20regional%20treatment%20pathways.%20We%20chose%20four%20regions%20of%20Germany%20with%20high%20utilisation%20of%20CAs%20for%20the%20study.%20Here%20we%20report%20the%20results%20of%20the%20concomitant%20qualitative%20study.%5CnMETHODS%3A%20General%20practitioners%20and%20specialist%20physicians%20%28cardiologists%2C%20hospital-based%20cardiologists%2C%20emergency%20physicians%2C%20radiologists%20and%20nuclear%20medicine%20specialists%29%20caring%20for%20patients%20with%20suspected%20CHD%20were%20invited%20to%20develop%20regional%20treatment%20pathways.%20Four%20academic%20departments%20provided%20support%20for%20moderation%2C%20provision%20of%20materials%2C%20etc.%20The%20study%20team%20observed%20session%20discussions%20and%20took%20notes.%20After%20the%20development%20of%20the%20treatment%20pathways%2C%2045%20semi-structured%20interviews%20were%20conducted%20with%20the%20participating%20physicians.%20Interviews%20and%20field%20notes%20were%20transcribed%20verbatim%20and%20underwent%20qualitative%20content%20analysis.%5CnRESULTS%3A%20Pathway%20development%20received%20little%20support%20among%20the%20participants.%20Although%20consensus%20documents%20were%20produced%2C%20the%20results%20were%20unlikely%20to%20improve%20practice.%20The%20participants%20expressed%20very%20little%20commitment%20to%20change.%20Although%20this%20attempt%20clearly%20failed%20in%20all%20study%20regions%2C%20our%20experience%20provides%20relevant%20insights%20into%20the%20process%20of%20evidence%20appraisal%20and%20implementation.%20A%20lack%20of%20organisational%20skills%2C%20ignorance%20of%20current%20evidence%20and%20guidelines%2C%20and%20a%20lack%20of%20feedback%20regarding%20one%26%23039%3Bs%20own%20clinical%20behaviour%20proved%20to%20be%20insurmountable.%20CA%20was%20still%20seen%20as%20the%20diagnostic%20gold%20standard%20by%20most%20interviewees.%5CnCONCLUSIONS%3A%20Oversupply%20and%20overutilisation%20can%20be%20assumed%20to%20be%20present%20in%20study%20regions%20but%20are%20not%20immediately%20perceived%20by%20clinicians.%20The%20problem%20is%20unlikely%20to%20be%20solved%20by%20regional%20collaborative%20initiatives%3B%20optimised%20resource%20planning%20within%20the%20health%20care%20system%20combined%20with%20appropriate%20economic%20incentives%20might%20best%20address%20these%20issues.%22%2C%22date%22%3A%222024-04-25%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12913-024-10904-5%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221472-6963%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22EBMCDUNP%22%2C%22R2J5Y2I9%22%2C%224KVK6YUS%22%5D%2C%22dateModified%22%3A%222025-04-09T10%3A06%3A42Z%22%7D%7D%2C%7B%22key%22%3A%22N2TQ7VUY%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Donner-Banzhoff%22%2C%22parsedDate%22%3A%222024-02-13%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BDonner-Banzhoff%2C%20Norbert.%20%26quot%3B%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fjournals.uni-marburg.de%5C%2Fobst%5C%2Farticle%5C%2Fview%5C%2F8639%26%23039%3B%26gt%3BWas%20z%5Cu00e4hlt%20als%20Argument%3F%20Belege%20und%20Begr%5Cu00fcndungen%20bei%20medizinischen%20Entscheidungen%26lt%3B%5C%2Fa%26gt%3B.%26quot%3B%20%26lt%3Bi%26gt%3BOsnabr%5Cu00fccker%20Beitr%5Cu00e4ge%20zur%20Sprachtheorie%26lt%3B%5C%2Fi%26gt%3B%20102%2C%20no.%20Sprache%2C%20Wissen%2C%20Macht.%20Zur%20sprachlichen%20Konstitution%20%28bio%29medizinischer%20und%20bioethischer%20Kommunikation%20%28February%2013%2C%202024%29.%20https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.17192%5C%2FOBST.2024.102.8639.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Was%20z%5Cu00e4hlt%20als%20Argument%3F%20Belege%20und%20Begr%5Cu00fcndungen%20bei%20medizinischen%20Entscheidungen%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%5D%2C%22abstractNote%22%3A%22Entscheidungen%20in%20Medizin%20und%20Gesundheitsversorgung%20sind%20ohne%20einen%20Bezug%20zur%20Evidenzbasierten%20Medizin%20%28EbM1%29%20kaum%20noch%20denkbar.%20Dieser%20Begriff%20steht%20f%5Cu00fcr%20einen%20sorgf%5Cu00e4ltigen%2C%20ausgewogenen%20und%20ausdr%5Cu00fccklichen%20Bezug%20auf%20einschl%5Cu00e4gige%20klinische%20Studien%20%28Sackett%20et%20al.%201996%29.%20Geht%20es%20um%20die%20Rechtfertigung%20medizinischer%20Ma%5Cu00dfnahmen%2C%20ist%20die%20Unterscheidung%20von%20zwei%20Arten%20von%20Entscheidungen%20zentral%3A%20der%20a%29%20Repertoire-%20und%20der%20b%29%20klinischen%20Entscheidung.%20Die%20erstere%20trifft%20eine%20Beh%5Cu00f6rde%20bei%20der%20Marktzulassung%20eines%20Medikaments%20oder%20ein%20Gesundheitssystem%20in%20Bezug%20auf%20die%20Kosten%5Cu00fcbernahme%20einer%20Technologie.%20Aber%20auch%20Praxen%20und%20Krankenh%5Cu00e4user%20m%5Cu00fcssen%20ihr%20Repertoire%20an%20diagnostischen%20und%20therapeutischen%20Ma%5Cu00dfnahmen%20festlegen.%20Dieses%20stellt%20f%5Cu00fcr%20die%20klinische%20Entscheidung%20an%20der%20einzelnen%20Patientin%20nur%20den%20Hintergrund%20dar.%20Es%20sind%20die%20Argumentationen%20%5Cu00fcber%20Repertoire-Entscheidungen%2C%20welche%20sich%20durch%20die%20Etablierung%20der%20EbM%20grundlegend%20ver%5Cu00e4ndert%20haben.%20Die%20Etablierung%20der%20EbM%20hat%20zu%20Machtverschiebungen%20gef%5Cu00fchrt.%20Da%20Studien%2C%20welche%20den%20Kriterien%20der%20EbM%20gen%5Cu00fcgen%2C%20sehr%20teuer%20sind%2C%20hat%20dies%20die%20Rolle%20von%20pharmazeutischer%20und%20Medizinprodukt-Industrie%20gest%5Cu00e4rkt%20und%20zu%20einer%20Oligopolisierung%20gef%5Cu00fchrt.%20Traditionelles%20pers%5Cu00f6nliches%20Wissen%20hat%20heute%20gegen%5Cu00fcber%20digitalen%20Datenbasen%2C%20Zeitschriften%20und%20Lehrb%5Cu00fcchern%20eine%20geringere%20Bedeutung.%20Studien%20im%20Sinne%20der%20EbM%20sind%20Voraussetzung%20f%5Cu00fcr%20die%20Entwicklung%20von%20Entscheidungshilfen%2C%20mit%20welchen%20sich%20Patientinnen%20an%20Entscheidungen%20%5Cu00fcber%20ihre%20Behandlung%20beteiligen%20k%5Cu00f6nnen.%20Vor%20dem%20Hintergrund%20kontroverser%20Diskussion%20um%20die%20EbM%20ist%20vor%20allem%20die%20weitgehende%20Akzeptanz%20der%20EbM-Standards%20bemerkenswert%5CnFor%20several%20decades%2C%20Evidence-based%20Medicine%20%28EBM%29%20has%20become%20the%20most%20important%20frame%20of%20reference%20for%20decisions%20in%20health%20care.%20It%20denotes%20%5Cu201cthe%20conscientious%2C%20explicit%2C%20and%20judicious%20use%20of%20current%20best%20evidence%20in%20making%20decisions%20about%20the%20care%20of%20individual%20patients%5Cu201d%20%28Sackett%20et%20al.%201996%29.%20Good%20patient%20care%20requires%20decisions%20at%20two%20levels%3A%20a%29%20the%20medical%20repertoire%3B%20b%29%20the%20individual%20clinical%20decision.%20The%20former%20must%20be%20made%20by%20an%20authority%20granting%20market%20access%20or%20by%20the%20health%20care%20system%20regarding%20coverage.%20Hospital%20departments%2C%20practices%20and%20individual%20clinicians%20must%20also%20decide%20which%20components%20should%20be%20part%20of%20their%20repertoire.%20For%20the%20individual%20clinical%20decision%2C%20the%20repertoireof%20available%20treatment%20options%20provides%20only%20thebackground.%20It%20is%20for%20the%20repertoire%20decision%20for%20which%20EBM%20has%20fundamentally%20changed%20what%20counts%20as%20an%20argument%20and%20what%20does%20not.%20The%20global%20spread%20of%20EBM%20has%20resulted%20in%20shifts%20of%20power%20and%20authority.%20Since%20trials%20meeting%20the%20methodological%20requirements%20of%20EBM%20are%20very%20expensive%2C%20the%20pharmaceutical%20and%20device%20industry%20has%20become%20a%20more%20powerful%20player%20in%20an%20oligopolistic%20market.%20Traditional%20personal%20academic%20knowledge%20and%20influence%20have%20been%20superseded%20by%20impersonal%20sources%20of%20knowledge%2C%20such%20as%20electronic%20databases%2C%20journals%2C%20and%20textbooks.%20Studies%20as%20favoured%20by%20EBM%20are%20necessary%20to%20develop%20decision%20aids%20aiming%20at%20involving%20patients%20for%20decisions%20affecting%20their%20health%20care.%20That%20the%20standards%20of%20EBM%20are%20almost%20universally%20accepted%20worldwide%20is%20most%20remarkable.%22%2C%22date%22%3A%222024-02-13%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.17192%5C%2FOBST.2024.102.8639%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fjournals.uni-marburg.de%5C%2Fobst%5C%2Farticle%5C%2Fview%5C%2F8639%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220936-0271%22%2C%22language%22%3A%22de%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22R2J5Y2I9%22%5D%2C%22dateModified%22%3A%222024-03-11T09%3A10%3A33Z%22%7D%7D%2C%7B%22key%22%3A%22M9BAUCCI%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Grede%20et%20al.%22%2C%22parsedDate%22%3A%222024-01-15%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGrede%2C%20Nina%2C%20Ulrike%20Trampisch%2C%20Sabine%20Weissbach%2C%20Monika%20Heinzel-Gutenbrunner%2C%20Ellen%20Freiberger%2C%20Andreas%20S%26%23xF6%3Bnnichsen%2C%20and%20Norbert%20Donner-Banzhoff.%20%26%23x201C%3BA%20Volunteer-Supported%20Walking%20Programme%20to%20Improve%20Physical%20Function%20in%20Older%20People%20with%20Restricted%20Mobility%20%28the%20POWER%20Study%29%3A%20A%20Randomised%20Controlled%20Trial.%26%23x201D%3B%20%26lt%3Bi%26gt%3BBMC%20Geriatrics%26lt%3B%5C%2Fi%26gt%3B%2024%2C%20no.%201%20%28January%2015%2C%202024%29%3A%2060.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12877-024-04672-4%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12877-024-04672-4%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22A%20volunteer-supported%20walking%20programme%20to%20improve%20physical%20function%20in%20older%20people%20with%20restricted%20mobility%20%28the%20POWER%20Study%29%3A%20a%20randomised%20controlled%20trial%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nina%22%2C%22lastName%22%3A%22Grede%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ulrike%22%2C%22lastName%22%3A%22Trampisch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Weissbach%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Monika%22%2C%22lastName%22%3A%22Heinzel-Gutenbrunner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ellen%22%2C%22lastName%22%3A%22Freiberger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22S%5Cu00f6nnichsen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Regular%20physical%20activity%20has%20multiple%20health%20benefits%2C%20especially%20in%20older%20people.%20Therefore%2C%20the%20World%20Health%20Organization%20recommends%20at%20least%202.5%5Cu00a0h%20of%20moderate%20physical%20activity%20per%20week.%20The%20aim%20of%20the%20POWER%20Study%20was%20to%20investigate%20whether%20volunteer-assisted%20walking%20improves%20the%20physical%20performance%20and%20health%20of%20older%20people.%5CnMETHODS%3A%20We%20approached%20people%20aged%2065%5Cu00a0years%20and%20older%20with%20restricted%20mobility%20due%20to%20physical%20limitations%20and%20asked%20them%20to%20participate%20in%20this%20multicentre%20randomised%20controlled%20trial.%20The%20recruitment%20took%20place%20in%20nursing%20homes%20and%20the%20community%20setting.%20Participants%20randomly%20assigned%20to%20the%20intervention%20group%20were%20accompanied%20by%20volunteer%20companions%20for%20a%2030-50%5Cu00a0min%20walk%20up%20to%20three%20times%20a%20week%20for%206%5Cu00a0months.%20Participants%20in%20the%20control%20group%20received%20two%20lectures%20that%20included%20health-related%20topics.%20The%20primary%20endpoint%20was%20physical%20function%20as%20measured%20with%20the%20Short%20Physical%20Performance%20Battery%20%28SPPB%29%20at%20baseline%20and%206%20and%2012%5Cu00a0months.%20The%20secondary%20and%20safety%20endpoints%20were%20quality%20of%20life%20%28EQ-5D-5L%29%2C%20fear%20of%20falling%20%28Falls%20Efficacy%20Scale%29%2C%20cognitive%20executive%20function%20%28the%20Clock%20Drawing%20Test%29%2C%20falls%2C%20hospitalisations%20and%20death.%5CnRESULTS%3A%20The%20sample%20comprised%20224%20participants%20%2879%25%20female%29.%20We%20failed%20to%20show%20superiority%20of%20the%20intervention%20with%20regard%20to%20physical%20function%20%28SPPB%29%20or%20other%20health%20outcomes%20in%20the%20intention-to-treat%20analyses.%20However%2C%20additional%20exploratory%20analyses%20suggest%20benefits%20in%20those%20who%20undertook%20regular%20walks.%20The%20intervention%20appears%20to%20be%20safe%20regarding%20falls.%5CnCONCLUSIONS%3A%20Regular%20physical%20activity%20is%20essential%20to%20preserve%20function%20and%20to%20improve%20health%20and%20quality%20of%20life.%20Against%20the%20background%20of%20a%20smaller-than-planned%20sample%20size%2C%20resulting%20in%20low%20power%2C%20and%20the%20interference%20of%20the%20COVID-19%20pandemic%2C%20we%20suggest%20that%20community%20based%20low-threshold%20interventions%20deserve%20further%20exploration.%5CnTRIAL%20REGISTRATION%3A%20The%20trial%20was%20registered%20with%20the%20German%20Clinical%20Trials%20Register%20%28%20www.germanctr.de%20%29%2C%20with%20number%20DRKS00015188%20on%2031%5C%2F08%5C%2F2018.%22%2C%22date%22%3A%222024-01-15%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12877-024-04672-4%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221471-2318%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22EBMCDUNP%22%2C%22R2J5Y2I9%22%5D%2C%22dateModified%22%3A%222025-04-09T10%3A19%3A29Z%22%7D%7D%2C%7B%22key%22%3A%22JTLLQT66%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Donner-Banzhoff%20and%20Gerlach%22%2C%22parsedDate%22%3A%222023-12-14%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BDonner-Banzhoff%2C%20Norbert%2C%20and%20Ferdinand%20Michael%20Gerlach.%20%26quot%3B%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttp%3A%5C%2F%5C%2Fwww.thieme-connect.de%5C%2FDOI%5C%2FDOI%3F10.1055%5C%2Fa-2189-2209%26%23039%3B%26gt%3BEin%20Vorschlag%20zur%20F%5Cu00f6rderung%20der%20%5Cu00e4rztlichen%20Weiterbildung%20im%20Kontext%20einer%20reformierten%20Krankenhausfinanzierung%26lt%3B%5C%2Fa%26gt%3B.%26quot%3B%20%26lt%3Bi%26gt%3BDas%20Gesundheitswesen%26lt%3B%5C%2Fi%26gt%3B%2C%20December%2014%2C%202023.%20https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1055%5C%2Fa-2189-2209.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Ein%20Vorschlag%20zur%20F%5Cu00f6rderung%20der%20%5Cu00e4rztlichen%20Weiterbildung%20im%20Kontext%20einer%20reformierten%20Krankenhausfinanzierung%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ferdinand%20Michael%22%2C%22lastName%22%3A%22Gerlach%22%7D%5D%2C%22abstractNote%22%3A%22In%20Deutschland%20werden%20die%20Anforderungen%20an%20die%20gebiets%5Cu00e4rztliche%20Qualifikation%20von%20den%20Landes%5Cu00e4rztekammern%20festgelegt.%20Deren%20Erf%5Cu00fcllung%20ist%20jedoch%20den%20%5Cu00c4rztinnen%20in%20Weiterbildung%20%5Cu00fcberlassen.%20Es%20fehlt%20eine%20Absch%5Cu00e4tzung%20des%20Bedarfs%20an%20Gebietsqualifikationen%2C%20ebenso%20eine%20entsprechende%20Steuerung.%20Allerdings%20werden%20Fehlentwicklungen%20immer%20wieder%20beklagt%2C%20so%20z.%20B.%20das%20Missverh%5Cu00e4ltnis%20von%20Haus-%20und%20Fach%5Cu00e4rztinnen%20im%20ambulanten%20Sektor.%20Wir%20schlagen%20eine%20systematische%20und%20kontinuierliche%20Bedarfssch%5Cu00e4tzung%20der%20einzelnen%20Fachgebiete%20vor.%20In%20solchen%2C%20wo%20eine%20Unterversorgung%20droht%2C%20w%5Cu00fcrde%20die%20Weiterbildung%20durch%20Zusch%5Cu00fcsse%20analog%20der%20aktuellen%20F%5Cu00f6rderung%20der%20Weiterbildung%20in%20der%20Allgemeinmedizin%20nach%20%5Cu00a7%2075a%20SGB%20V%20inzentiviert.%20Regionale%20fachspezifische%20Weiterbildungsverb%5Cu00fcnde%20w%5Cu00fcrden%20f%5Cu00fcr%20eine%20Allokation%20der%20Mittel%20an%20Institutionen%20mit%20evaluierter%20Qualit%5Cu00e4t%20der%20Weiterbildung%20sorgen.%20Das%20Verfahren%20l%5Cu00e4sst%20sich%20kostenneutral%20gestalten%2C%20wenn%20ein%20Teil%20der%20Mittel%20aus%20den%20aktuellen%20Behandlungsentgelten%2C%20die%20implizit%20auch%20der%20Weiterbildung%20dienen%2C%20k%5Cu00fcnftig%20explizit%20f%5Cu00fcr%20eine%20Steuerung%2C%20Koordination%20und%20Verbesserung%20der%20Weiterbildung%20genutzt%20werden.%20Diese%20M%5Cu00f6glichkeit%20besteht%20unabh%5Cu00e4ngig%20vom%20Mechanismus%20der%20Entgelte%20f%5Cu00fcr%20station%5Cu00e4re%20oder%20ambulante%20Leistungen.%22%2C%22date%22%3A%222023%5C%2F12%5C%2F14%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1055%5C%2Fa-2189-2209%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fwww.thieme-connect.de%5C%2FDOI%5C%2FDOI%3F10.1055%5C%2Fa-2189-2209%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%220941-3790%2C%201439-4421%22%2C%22language%22%3A%22de%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22R2J5Y2I9%22%2C%22SPWXRLZV%22%2C%22QXIGN3AI%22%2C%22BEQ38XPW%22%2C%22P9CVNWVH%22%2C%22WK7W2JLX%22%5D%2C%22dateModified%22%3A%222024-05-26T16%3A25%3A23Z%22%7D%7D%2C%7B%22key%22%3A%227QEYH5SY%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Heisig%20et%20al.%22%2C%22parsedDate%22%3A%222023-12-07%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BHeisig%2C%20Julia%2C%20Bettina%20B%26%23xFC%3Bcker%2C%20Alexandra%20Schmidt%2C%20Anne-Lisa%20Heye%2C%20Anja%20Rieckert%2C%20Susanne%20L%26%23xF6%3Bscher%2C%20Oliver%20Hirsch%2C%20et%20al.%20%26%23x201C%3BEfficacy%20of%20a%20Computer%20Based%20Discontinuation%20Strategy%20to%20Reduce%20PPI%20Prescriptions%3A%20A%20Multicenter%20Cluster-Randomized%20Controlled%20Trial.%26%23x201D%3B%20%26lt%3Bi%26gt%3BScientific%20Reports%26lt%3B%5C%2Fi%26gt%3B%2013%2C%20no.%201%20%28December%207%2C%202023%29%3A%2021633.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-023-48839-2%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-023-48839-2%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Efficacy%20of%20a%20computer%20based%20discontinuation%20strategy%20to%20reduce%20PPI%20prescriptions%3A%20a%20multicenter%20cluster-randomized%20controlled%20trial%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Heisig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Bettina%22%2C%22lastName%22%3A%22B%5Cu00fccker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne-Lisa%22%2C%22lastName%22%3A%22Heye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anja%22%2C%22lastName%22%3A%22Rieckert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Susanne%22%2C%22lastName%22%3A%22L%5Cu00f6scher%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Hirsch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Wilm%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anne%22%2C%22lastName%22%3A%22Barzel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Becker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annika%22%2C%22lastName%22%3A%22Viniol%22%7D%5D%2C%22abstractNote%22%3A%22Deprescribing%20of%20inappropriate%20long-term%20proton%20pump%20inhibitors%20%28PPI%29%20is%20challenging%20and%20there%20is%20a%20lack%20of%20useful%20methods%20for%20general%20practitioners%20to%20tackle%20this.%20The%20objective%20of%20this%20randomized%20controlled%20trial%20was%20to%20evaluate%20the%20effectiveness%20of%20the%20electronic%20decision%20aid%20tool%20arriba-PPI%20on%20reduction%20of%20long-term%20PPI%20intake.%20Participants%20%2864.5%5Cu2009%5Cu00b1%5Cu200912.9%20years%3B%2054.4%25%20women%29%20with%20a%20PPI%20intake%20of%20at%20least%206%20months%20were%20randomized%20to%20receive%20either%20consultation%20with%20arriba-PPI%20from%20their%20general%20practitioner%20%28n%5Cu2009%3D%5Cu20091256%29%20or%20treatment%20as%20usual%20%28n%5Cu2009%3D%5Cu20091131%29.%20PPI%20prescriptions%20were%20monitored%206%20months%20before%2C%206%20and%2012%20months%20after%20study%20initiation.%20In%2049.2%25%20of%20the%20consultations%20with%20arriba-PPI%2C%20the%20general%20practitioners%20and%20their%20patients%20made%20the%20decision%20to%20reduce%20or%20discontinue%20PPI%20intake.%20At%206%20months%2C%20there%20was%20a%20significant%20reduction%20by%2022.3%25%20%2895%25%20CI%2018.55%20to%2025.98%3B%20p%5Cu2009%26lt%3B%5Cu20090.0001%29%20of%20defined%20daily%20doses%20%28DDD%29%20of%20PPI.%20A%20reduction%20of%203.3%25%20%2895%25%20CI%20-%5Cu00a07.18%20to%5Cu2009%2B%5Cu20090.62%29%20was%20observed%20in%20the%20control%20group.%20At%2012%20months%2C%20the%20reduction%20of%20DDD-PPI%20remained%20stable%20in%20intervention%20patients%20%28%2B%5Cu20093.5%25%2C%2095%25%20CI%20-%5Cu00a00.99%20to%5Cu2009%2B%5Cu20098.03%29%2C%20whereas%20control%20patients%20showed%20a%20reduction%20of%20DDD-PPI%20%28-%5Cu00a010.2%25%2C%2095%25%20CI%20-%5Cu00a06.01%20to%20-%5Cu00a014.33%29.%20Consultation%20with%20arriba-PPI%20led%20to%20reduced%20prescription%20rates%20of%20PPI%20in%20primary%20care%20practices.%20Arriba-PPI%20can%20be%20a%20helpful%20tool%20for%20general%20practitioners%20to%20start%20a%20conversation%20with%20their%20patients%20about%20risks%20of%20long-term%20PPI%20intake%2C%20reduction%20or%20deprescribing%20unnecessary%20PPI%20medication.%22%2C%22date%22%3A%222023-12-07%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-023-48839-2%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222045-2322%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22R2J5Y2I9%22%2C%22SPWXRLZV%22%2C%22SG8SD8IJ%22%2C%22QXIGN3AI%22%5D%2C%22dateModified%22%3A%222024-03-11T09%3A11%3A07Z%22%7D%7D%2C%7B%22key%22%3A%22AWSSVA2V%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zeschick%20et%20al.%22%2C%22parsedDate%22%3A%222023-09-07%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BZeschick%2C%20Nikoletta%2C%20Julia%20Gollnick%2C%20Julia%20Muth%2C%20Franziska%20H%5Cu00f6rbrand%2C%20Peter%20Killian%2C%20Norbert%20Donner-Banzhoff%2C%20Thomas%20K%5Cu00fchlein%2C%20and%20Maria%20Sebasti%5Cu00e3o.%20%26quot%3B%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC10483772%5C%2F%26%23039%3B%26gt%3BPhysicians%26%23039%3B%20assessment%20of%20the%20Bavarian%20drug-expenditure%20control%20system%3A%20a%20qualitative%20study%26lt%3B%5C%2Fa%26gt%3B.%26quot%3B%20%26lt%3Bi%26gt%3BBMC%20Health%20Services%20Research%26lt%3B%5C%2Fi%26gt%3B%2023%20%28September%207%2C%202023%29%3A%20961.%20https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12913-023-09844-3.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Physicians%27%20assessment%20of%20the%20Bavarian%20drug-expenditure%20control%20system%3A%20a%20qualitative%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nikoletta%22%2C%22lastName%22%3A%22Zeschick%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Gollnick%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Muth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Franziska%22%2C%22lastName%22%3A%22H%5Cu00f6rbrand%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%22%2C%22lastName%22%3A%22Killian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22K%5Cu00fchlein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%22%2C%22lastName%22%3A%22Sebasti%5Cu00e3o%22%7D%5D%2C%22abstractNote%22%3A%22Background%5CnIn%202014%20a%20new%20system%20for%20drug%20expenditures%2C%20the%20Wirkstoffvereinbarung%20%28WSV%2C%20English%3A%20Active%20substance%20agreement%29%20was%20implemented%20in%20Bavaria.%20In%20pre-defined%20indication%20groups%2C%20economic%20prescription%20of%20medications%20shall%20be%20enabled%20based%20on%20the%20selection%2C%20quantity%2C%20and%20proportion%20of%20an%20individual%20drug.%20Ambulatory%20care%20physicians%20receive%20quarterly%20trend%20reports%20on%20their%20prescribing%20behavior.%20This%20study%20examines%20physicians%5Cu2019%20perceptions%20of%20the%20WSV.%5Cn%5CnMethods%5CnQualitative%20interviews%20%28n%5Cu2009%3D%5Cu200920%29%20and%20seven%20focus%20groups%20%28n%5Cu2009%3D%5Cu200936%29%20were%20conducted%20with%20ambulatory%20care%20physicians%20%28e.g.%20general%20practitioners%2C%20cardiologists%2C%20pulmonologists%29.%20The%20methodology%20followed%20Qualitative%20Content%20Analysis.%5Cn%5CnResults%5CnPhysicians%20generally%20accepted%20the%20necessity%20of%20prescribing%20economically.%20The%20majority%20of%20them%20rated%20the%20WSV%20positively%20and%20better%20than%20the%20previous%20system.%20As%20an%20improvement%2C%20they%20especially%20named%20timely%20feedback%20in%20form%20of%20easily%20understandable%20trend%20reports%2C%20encouraging%20self-reflection%20as%20well%20as%20allowing%20early%20control%20options.%20Problems%20perceived%20were%20drug%20discount%20contracts%20that%20were%20strongly%20criticized%20as%20leading%20to%20patients%20mixing%20up%20medications.%20Some%20perceived%20constraints%20of%20therapeutic%20freedom.%5Cn%5CnConclusions%5CnThe%20implementation%20of%20the%20WSV%20is%20mostly%20viewed%20positively%20by%20physicians.%20The%20restrictions%20of%20therapeutic%20freedom%20partially%20perceived%20might%20be%20met%20by%20improved%20information%20on%20the%20reasons%20why%20some%20drugs%20are%20rated%20as%20less%20economical%20than%20others.%5Cn%5CnTrial%20registration%20number%5CnMain%20ID%3A%20DRKS00019820%20%28German%20Register%20of%20Clinical%20Studies%20and%20World%20Health%20Organization%29.%5Cn%5CnSupplementary%20Information%5CnThe%20online%20version%20contains%20supplementary%20material%20available%20at%2010.1186%5C%2Fs12913-023-09844-3.%22%2C%22date%22%3A%222023-9-7%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12913-023-09844-3%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC10483772%5C%2F%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221472-6963%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22R2J5Y2I9%22%2C%22X7PUUBWP%22%2C%22SPWXRLZV%22%2C%22QXIGN3AI%22%5D%2C%22dateModified%22%3A%222024-03-13T08%3A08%3A30Z%22%7D%7D%2C%7B%22key%22%3A%22UF3X9BPU%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Weissbach%20et%20al.%22%2C%22parsedDate%22%3A%222023-06-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BWeissbach%2C%20Sabine%2C%20Anja%20Rieckert%2C%20Christine%20Kersting%2C%20Nina%20Grede%2C%20Norbert%20Donner-Banzhoff%2C%20Andreas%20Soennichsen%2C%20Horst%20Christian%20Vollmar%2C%20Ina%20Otte%2C%20Pia%20Weimer%2C%20and%20Ulrike%20Sonja%20Trampisch.%20%26%23x201C%3BExperiences%20of%20Participants%20of%20a%20Volunteer-Supported%20Walking%20Intervention%20to%20Improve%20Physical%20Function%20of%20Nursing%20Home%20Residents%20-%20a%20Mixed%20Methods%20Sub-Study%20of%20the%20POWER-Project.%26%23x201D%3B%20%26lt%3Bi%26gt%3BBMC%20Geriatrics%26lt%3B%5C%2Fi%26gt%3B%2023%2C%20no.%201%20%28June%201%2C%202023%29%3A%20343.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12877-023-04044-4%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12877-023-04044-4%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Experiences%20of%20participants%20of%20a%20volunteer-supported%20walking%20intervention%20to%20improve%20physical%20function%20of%20nursing%20home%20residents%20-%20a%20mixed%20methods%20sub-study%20of%20the%20POWER-project%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Weissbach%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anja%22%2C%22lastName%22%3A%22Rieckert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christine%22%2C%22lastName%22%3A%22Kersting%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nina%22%2C%22lastName%22%3A%22Grede%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22Soennichsen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Horst%20Christian%22%2C%22lastName%22%3A%22Vollmar%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ina%22%2C%22lastName%22%3A%22Otte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pia%22%2C%22lastName%22%3A%22Weimer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ulrike%20Sonja%22%2C%22lastName%22%3A%22Trampisch%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Regular%20physical%20activity%20improves%20physical%20health%20and%20mental%20well-being%20and%20reduces%20the%20risk%20of%20falling%20in%20older%20adults.%20The%20randomized%20controlled%20%26quot%3BPrevention%20by%20lay-assisted%20Outdoor-Walking%20in%20the%20Elderly%20at%20Risk%26quot%3B%20POWER-study%20investigates%20whether%20volunteer-supported%20outdoor-walking%20improves%20physical%20function%20and%20quality%20of%20life%20in%20older%20people%20living%20independently%20or%20in%20nursing%20homes.%20This%20sub-study%20explores%20the%20experiences%20of%20older%20participants%20and%20volunteers%20in%20relation%20to%20their%20physical%20and%20psychosocial%20well-being%20as%20well%20as%20the%20challenges%20faced%20by%20both%20groups.%20A%20further%20aim%20was%20to%20explore%20volunteers%26%23039%3B%20experience%20with%20people%20living%20in%20nursing%20homes%20during%20the%20first%20pandemic%20lockdown%20%28spring%202020%29.%5CnMETHODS%3A%20The%20sub-study%20was%20designed%20as%20mixed-methods%20approach%20consisting%20of%2011%20individual%20semi-structured%20guide-based%20interviews%20%28nursing%20home%20residents%29%2C%20two%20focus%20group%20interviews%20%28volunteers%29%2C%20and%20a%20cross-sectional%20questionnaire%20survey%20%28volunteers%29.%20The%20interviews%20were%20audiotaped%2C%20transcribed%20verbatim%2C%20and%20analyzed%20by%20content%20analysis%20as%20described%20by%20Kuckartz.%20Topics%20addressed%20in%20the%20interviews%20were%20triangulated%20by%20means%20of%20a%20questionnaire.%20The%20quantitative%20data%20were%20analyzed%20using%20descriptive%20statistics.%5CnRESULTS%3A%20Participants%26%23039%3B%20evaluation%20of%20the%20intervention%20was%20generally%20positive.%20Nursing%20home%20residents%20appreciated%20the%20social%20interaction%20associated%20with%20the%20assisted%20walking%2C%20which%20motivated%20them%20to%20take%20part%20regularly%2C%20provided%20a%20sense%20of%20safety%2C%20and%20caused%20pleasure%20on%20both%20sides.%20The%20impact%20on%20physical%20health%20status%20of%20the%20nursing%20home%20residents%20of%20this%20sub-study%20varied%20to%20a%20large%20degree%20as%20reported%20in%20interviews%3A%20in%20some%20cases%2C%20an%20improvement%20in%20physical%20performance%2C%20a%20decrease%20in%20physical%20complaints%2C%20and%20an%20improvement%20in%20gait%20or%20independence%20was%20reported.%20If%20not%2C%20reference%20was%20made%20to%20previous%20or%20sudden%20illnesses%20and%20the%20advanced%20age%20of%20the%20participants.%20Despite%20the%20COVID-19-lockdown%20and%20the%20associated%20restrictions%2C%20about%2060%25%20of%20contacts%20were%20still%20possible%20and%20participants%20planned%20to%20continue%20the%20assisted%20walks%20after%20the%20lockdown.%5CnCONCLUSION%3A%20Volunteers%20have%20a%20positive%20effect%20on%20the%20quality%20of%20life%2C%20mobility%2C%20and%20general%20health%20of%20nursing%20home%20residents.%20Even%20more%20than%20the%20improvement%20of%20physical%20performance%2C%20social%20interaction%20was%20seen%20as%20helpful.%20Despite%20their%20advanced%20age%2C%20the%20nursing%20home%20residents%20were%20curious%20and%20open%20to%20new%20contacts.%20When%20removing%20the%20identified%20barriers%2C%20it%20might%20be%20possible%20to%20integrate%20this%20program%20into%20the%20long-term%20everyday%20life%20of%20nursing%20homes.%5CnTRIAL%20REGISTRATION%3A%20DRKS-ID%3A%20DRKS00015188%2C%20date%20of%20registration%3A%2031.08.2018.%22%2C%22date%22%3A%222023-06-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12877-023-04044-4%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221471-2318%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%226DTIS6M4%22%2C%22R2J5Y2I9%22%2C%22N24UXA6K%22%2C%226CWITS3E%22%5D%2C%22dateModified%22%3A%222024-06-05T09%3A02%3A21Z%22%7D%7D%2C%7B%22key%22%3A%22E3YAN5VU%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Winkler%20et%20al.%22%2C%22parsedDate%22%3A%222023-05-02%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BWinkler%2C%20Katja%2C%20Navina%20Gerlach%2C%20Norbert%20Donner-Banzhoff%2C%20Anika%20Berberich%2C%20Jutta%20Jung-Henrich%2C%20and%20Kathrin%20Schl%26%23xF6%3B%26%23xDF%3Bler.%20%26%23x201C%3BDeterminants%20of%20Referral%20for%20Suspected%20Coronary%20Artery%20Disease%3A%20A%20Qualitative%20Study%20Based%20on%20Decision%20Thresholds.%26%23x201D%3B%20%26lt%3Bi%26gt%3BBMC%20Primary%20Care%26lt%3B%5C%2Fi%26gt%3B%2024%2C%20no.%201%20%28May%202%2C%202023%29%3A%20110.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12875-023-02064-y%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12875-023-02064-y%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Determinants%20of%20referral%20for%20suspected%20coronary%20artery%20disease%3A%20a%20qualitative%20study%20based%20on%20decision%20thresholds%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katja%22%2C%22lastName%22%3A%22Winkler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Navina%22%2C%22lastName%22%3A%22Gerlach%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anika%22%2C%22lastName%22%3A%22Berberich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jutta%22%2C%22lastName%22%3A%22Jung-Henrich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22Schl%5Cu00f6%5Cu00dfler%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Chest%20pain%20is%20a%20frequent%20consultation%20issue%20in%20primary%20care%2C%20with%20coronary%20artery%20disease%20%28CAD%29%20being%20a%20serious%20potential%20cause.%20Primary%20care%20physicians%20%28PCPs%29%20assess%20the%20probability%20for%20CAD%20and%20refer%20patients%20to%20secondary%20care%20if%20necessary.%20Our%20aim%20was%20to%20explore%20PCPs%26%23039%3B%20referral%20decisions%2C%20and%20to%20investigate%20determinants%20which%20influenced%20those%20decisions.%5CnMETHODS%3A%20PCPs%20working%20in%20Hesse%2C%20Germany%2C%20were%20interviewed%20in%20a%20qualitative%20study.%20We%20used%20%26%23039%3Bstimulated%20recall%26%23039%3B%20with%20participants%20to%20discuss%20patients%20with%20suspected%20CAD.%20With%20a%20sample%20size%20of%2026%20cases%20from%20nine%20practices%20we%20reached%20inductive%20thematic%20saturation.%20Interviews%20were%20audio-recorded%2C%20transcribed%20verbatim%20and%20analyzed%20by%20inductive-deductive%20thematic%20content%20analysis.%20For%20the%20final%20interpretation%20of%20the%20material%2C%20we%20used%20the%20concept%20of%20decision%20thresholds%20proposed%20by%20Pauker%20and%20Kassirer.%5CnRESULTS%3A%20PCPs%20reflected%20on%20their%20decisions%20for%20or%20against%20a%20referral.%20Aside%20from%20patient%20characteristics%20determining%20disease%20probability%2C%20we%20identified%20general%20factors%20which%20can%20be%20understood%20as%20influencing%20the%20referral%20threshold.%20These%20factors%20relate%20to%20the%20practice%20environment%2C%20to%20PCPs%20themselves%20and%20to%20non-diagnostic%20patient%20characteristics.%20Proximity%20of%20specialist%20practice%2C%20relationship%20with%20specialist%20colleagues%2C%20and%20trust%20played%20a%20role.%20PCPs%20sometimes%20felt%20that%20invasive%20procedures%20were%20performed%20too%20easily.%20They%20tried%20to%20steer%20their%20patients%20through%20the%20system%20with%20the%20intent%20to%20avoid%20over-treatment.%20Most%20PCPs%20were%20unaware%20of%20guidelines%20but%20relied%20on%20informal%20local%20consensus%2C%20largely%20influenced%20by%20specialists.%20As%20a%20result%2C%20PCPs%20gatekeeping%20role%20was%20limited.%5CnCONCLUSIONS%3A%20We%20could%20identify%20a%20large%20number%20of%20factors%20that%20impact%20referral%20for%20suspected%20CAD.%20Several%20of%20these%20factors%20offer%20possibilities%20to%20improve%20care%20at%20the%20clinical%20and%20system%20level.%20The%20threshold%20model%20proposed%20by%20Pauker%20and%20Kassirer%20was%20a%20useful%20framework%20for%20this%20kind%20of%20data%20analysis.%22%2C%22date%22%3A%222023-05-02%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12875-023-02064-y%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222731-4553%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22R2J5Y2I9%22%2C%22X7PUUBWP%22%2C%22SPWXRLZV%22%2C%22QXIGN3AI%22%2C%22P9CVNWVH%22%5D%2C%22dateModified%22%3A%222025-05-18T07%3A35%3A06Z%22%7D%7D%2C%7B%22key%22%3A%22BB7ABBT7%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22W%5Cu00e4chtler%20et%20al.%22%2C%22parsedDate%22%3A%222023-03-20%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BW%26%23xE4%3Bchtler%2C%20Hannelore%2C%20Hanna%20Kaduszkiewicz%2C%20Oskar%20Kuhnert%2C%20Karolina%20Agata%20Malottki%2C%20Sonja%20Maa%26%23xDF%3B%2C%20J%26%23xFC%3Brgen%20Hedderich%2C%20Birgitt%20Wiese%2C%20Norbert%20Donner-Banzhoff%2C%20and%20Julia%20Hansmann-Wiest.%20%26%23x201C%3BInfluence%20of%20a%20Guideline%20or%20an%20Additional%20Rapid%20Strep%20Test%20on%20Antibiotic%20Prescriptions%20for%20Sore%20Throat%3A%20The%20Cluster%20Randomized%20Controlled%20Trial%20of%20HALS%20%28Hals%20Und%20Antibiotika%20Leitlinien%20Strategien%29.%26%23x201D%3B%20%26lt%3Bi%26gt%3BBMC%20Primary%20Care%26lt%3B%5C%2Fi%26gt%3B%2024%2C%20no.%201%20%28March%2020%2C%202023%29%3A%2075.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12875-023-01987-w%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12875-023-01987-w%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Influence%20of%20a%20guideline%20or%20an%20additional%20rapid%20strep%20test%20on%20antibiotic%20prescriptions%20for%20sore%20throat%3A%20the%20cluster%20randomized%20controlled%20trial%20of%20HALS%20%28Hals%20und%20Antibiotika%20Leitlinien%20Strategien%29%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hannelore%22%2C%22lastName%22%3A%22W%5Cu00e4chtler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hanna%22%2C%22lastName%22%3A%22Kaduszkiewicz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oskar%22%2C%22lastName%22%3A%22Kuhnert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karolina%20Agata%22%2C%22lastName%22%3A%22Malottki%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sonja%22%2C%22lastName%22%3A%22Maa%5Cu00df%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00fcrgen%22%2C%22lastName%22%3A%22Hedderich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Birgitt%22%2C%22lastName%22%3A%22Wiese%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Hansmann-Wiest%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Pharyngitis%20due%20to%20Group%20A%20beta-hemolytic%20streptococci%20%28GAS%29%20is%20seen%20as%20the%20main%20indication%20for%20antibiotics%20for%20sore%20throat.%20In%20primary%20care%20settings%20prescription%20rates%20are%20much%20higher%20than%20the%20prevalence%20of%20GAS.%20Recommendations%20in%20international%20guidelines%20differ%20considerably.%20A%20German%20guideline%20suggested%20to%20consider%20antibiotics%20for%20patients%20with%20Centor%20or%20McIsaac%20scores%5Cu2009%5Cu2265%5Cu20093%2C%20first%20choice%20being%20penicillin%20V%20for%207%5Cu00a0days%2C%20and%20recommended%20analgesics%20for%20all.%20We%20investigated%2C%20if%20the%20implementation%20of%20this%20guideline%20lowers%20the%20antibiotic%20prescription%20rate%2C%20and%20if%20a%20rapid%20antigen%20detection%20strep-test%20%28RADT%29%20in%20patients%20with%20scores%5Cu2009%5Cu2265%5Cu20093%20lowers%20the%20rate%20further.%5CnMETHODS%3A%20HALS%20was%20an%20open%20pragmatic%20parallel%20group%20three-arm%20cluster-randomized%20controlled%20trial.%20Primary%20care%20practices%20in%20Northern%20Germany%20were%20randomized%20into%20three%20groups%3A%20Guideline%20%28GL-group%29%2C%20modified%20guideline%20with%20a%20RADT%20for%20scores%5Cu2009%5Cu2265%5Cu20093%20%28GL-RADT-group%29%20or%20usual%20care%20%28UC-group%29.%20All%20practices%20were%20visited%20and%20instructed%20by%20the%20study%20team%20%28outreach%20visits%29%20and%20supplied%20with%20material%20according%20to%20their%20group.%20The%20practices%20were%20asked%20to%20recruit%2011%20consecutive%20patients%5Cu2009%5Cu2265%5Cu20092%5Cu00a0years%20with%20an%20acute%20sore%20throat%20and%20being%20at%20least%20moderately%20impaired.%20A%20study%20throat%20swab%20for%20GAS%20was%20taken%20in%20every%20patient.%20The%20antibiotic%20prescription%20rate%20at%20the%20first%20consultation%20was%20the%20primary%20outcome.%5CnRESULTS%3A%20From%20October%202010%20to%20March%202012%2C%2068%20general%20practitioners%20in%2061%20practices%20recruited%20520%20patients%2C%20516%20could%20be%20analyzed%20for%20the%20primary%20endpoint.%20Antibiotic%20prescription%20rates%20did%20not%20differ%20between%20groups%20%28p%5Cu2009%3D%5Cu20090.162%29%20and%20were%20about%20three%20times%20higher%20than%20the%20GAS%20rate%3A%20GL-group%2097%5C%2F187%20patients%20%2852%25%3B%20GAS%5Cu2009%3D%5Cu200916%25%29%2C%20GL-RADT-group%2074%5C%2F172%20%2843%25%3B%20GAS%5Cu2009%3D%5Cu200916%25%29%20and%20UC-group%2068%5C%2F157%20%2843%25%3B%20GAS%5Cu2009%3D%5Cu200914%25%29.%20In%20the%20GL-RADT-group%2055%25%20of%20patients%20had%20scores%5Cu2009%5Cu2265%5Cu20093%20compared%20to%2035%25%20in%20GL-group%20%28p%5Cu2009%26lt%3B%5Cu20090.001%29.%20After%20adjustment%2C%20in%20the%20GL-RADT-group%20the%20OR%20was%200.23%20for%20getting%20an%20antibiotic%20compared%20to%20the%20GL-group%20%28p%5Cu2009%3D%5Cu20090.010%29%2C%20even%20though%2035%20of%2090%20patients%20with%20a%20negative%20Strep-test%20got%20an%20antibiotic%20in%20the%20GL-RADT-group.%20The%20prescription%20rates%20per%20practice%20covered%20the%20full%20range%20from%200%20to%20100%25%20in%20all%20groups.%5CnCONCLUSION%3A%20The%20scores%20proposed%20in%20the%20implemented%20guideline%20seem%20inappropriate%20to%20lower%20antibiotic%20prescriptions%20for%20sore%20throat%2C%20but%20better%20adherence%20of%20practitioners%20to%20negative%20RADTs%20should%20lead%20to%20fewer%20prescriptions.%5CnTRIAL%20REGISTRATION%3A%20DRKS00013018%2C%20retrospectively%20registered%2028.11.2017.%22%2C%22date%22%3A%222023-03-20%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12875-023-01987-w%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222731-4553%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%226DTIS6M4%22%2C%22R2J5Y2I9%22%2C%22SPWXRLZV%22%2C%224KVK6YUS%22%2C%22P9CVNWVH%22%5D%2C%22dateModified%22%3A%222024-03-11T09%3A10%3A51Z%22%7D%7D%2C%7B%22key%22%3A%22BKADBGKY%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Grede%20et%20al.%22%2C%22parsedDate%22%3A%222023-01-26%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGrede%2C%20Nina%2C%20Katrin%20Kuss%2C%20Ina%20Staudt%2C%20Norbert%20Donner-Banzhoff%2C%20and%20Annika%20Viniol.%20%26%23x201C%3BMapping%20the%20Methodological%20Diversity%20of%20Published%20Drug%20Discontinuation%20Studies-a%20Scoping%20Review%20of%20Study%20Topics%2C%20Objectives%2C%20and%20Designs.%26%23x201D%3B%20%26lt%3Bi%26gt%3BTrials%26lt%3B%5C%2Fi%26gt%3B%2024%2C%20no.%201%20%28January%2026%2C%202023%29%3A%2058.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs13063-023-07105-6%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs13063-023-07105-6%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Mapping%20the%20methodological%20diversity%20of%20published%20drug%20discontinuation%20studies-a%20scoping%20review%20of%20study%20topics%2C%20objectives%2C%20and%20designs%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nina%22%2C%22lastName%22%3A%22Grede%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katrin%22%2C%22lastName%22%3A%22Kuss%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ina%22%2C%22lastName%22%3A%22Staudt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annika%22%2C%22lastName%22%3A%22Viniol%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Trials%20evaluating%20drug%20discontinuation%20%28drug%20discontinuation%20trials%2C%20DDTs%29%20show%20a%20broad%20methodological%20spectrum.%20There%20are%20several%20specific%20methodological%20aspects%20in%20drug%20discontinuation%20trials%20%28e.g.%2C%20determination%20of%20research%20question%3B%20configuration%20of%20intervention%3B%20definition%20of%20outcomes%29.%20To%20verify%20this%20specifies%2C%20we%20did%20a%20scoping%20review%20about%20the%20study%20designs%20of%20drug%20discontinuation%20trials.%5CnMETHODS%3A%20A%20systematic%20literature%20search%20in%20Medline%20%28PubMed%29%2C%20The%20Cochrane%20Library%2C%20EMBASE%2C%20CINAHL%2C%20Web%20of%20Science%2C%20and%20PsycINFO%20was%20performed.%20In%20a%20two-step%20selection%20process%2C%20we%20identified%20DDTs%2C%20which%20evaluate%20the%20discontinuation%20of%20one%20or%20more%20long-term%20medication%20as%20the%20investigated%20intervention%2C%20by%20two%20independent%20reviewers.%20Besides%20bibliographic%20data%2C%20we%20extracted%20several%20parameters%20to%20describe%20the%20used%20study%20design%20of%20the%20included%20DDTs%3A%20motivation%20for%20DDT%2C%20initially%20treatment%20aim%20of%20the%20discontinued%20medication%2C%20study%20design%2C%20methods%20of%20discontinuation%2C%20follow-up%20times%2C%20number%20of%20study%20participants%2C%20and%20outcome%20parameter.%5CnRESULTS%3A%20Out%20of%2012%2C132%20records%2C%20we%20included%20581%20DDTs.%20The%20most%20common%20motivation%20for%20doing%20a%20DDT%20were%20expected%20side%20effects%20%2848.8%25%29%2C%20the%20motivation%20of%20proving%20the%20efficacy%20of%20medication%20%2821.6%25%29%2C%20or%20doubts%20on%20the%20expected%20benefit%20of%20the%20used%20medication%20%2813.8%25%29.%20The%20majority%20of%20the%20discontinued%20medication%20was%20initially%20prescribed%20to%20improve%20the%20prognosis%20of%20a%20chronic%20disease%20%2860.4%25%29%20or%20to%20relieve%20symptoms%20%2831%25%29.%20The%20study%20designs%20of%20the%20trials%20showed%20a%20broad%20methodological%20spectrum.%20The%20minority%20of%20the%20drug%20discontinuation%20trials%20were%20randomized%20controlled%20trials%20%2834%25%29.%5CnCONCLUSION%3A%20The%20results%20of%20this%20scoping%20review%20illustrates%20the%20need%20for%20an%20evidence-based%20methodological%20standard%20for%20planning%20and%20conducting%20drug%20discontinuation%20trials.%22%2C%22date%22%3A%222023-01-26%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs13063-023-07105-6%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221745-6215%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22R2J5Y2I9%22%2C%22X7PUUBWP%22%2C%228B2HH96K%22%5D%2C%22dateModified%22%3A%222024-03-11T09%3A12%3A29Z%22%7D%7D%2C%7B%22key%22%3A%22GPWUIGPN%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Flemming%20et%20al.%22%2C%22parsedDate%22%3A%222023-01-06%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BFlemming%2C%20Ronja%2C%20Franziska%20Fr%26%23xF6%3Blich%2C%20Norbert%20Donner-Banzhoff%2C%20and%20Leonie%20Sundmacher.%20%26%23x201C%3BDiffusion%20of%20a%20New%20Drug%20among%20Ambulatory%20Physicians-The%20Impact%20of%20Patient%20Pathways.%26%23x201D%3B%20%26lt%3Bi%26gt%3BHealth%20Economics%26lt%3B%5C%2Fi%26gt%3B%2C%20January%206%2C%202023.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fhec.4650%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fhec.4650%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Diffusion%20of%20a%20new%20drug%20among%20ambulatory%20physicians-The%20impact%20of%20patient%20pathways%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ronja%22%2C%22lastName%22%3A%22Flemming%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Franziska%22%2C%22lastName%22%3A%22Fr%5Cu00f6lich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leonie%22%2C%22lastName%22%3A%22Sundmacher%22%7D%5D%2C%22abstractNote%22%3A%22When%20drugs%20enter%20the%20market%2C%20physicians%26%23039%3B%20prescribing%20behavior%20plays%20a%20crucial%20role%20in%20the%20diffusion%20process.%20Although%20regulations%20to%20foster%20economically%20efficient%20prescribing%20exist%2C%20physicians%20have%20some%20degree%20of%20freedom%20in%20choosing%20medication%20and%20are%20subject%20to%20various%20influencing%20factors.%20The%20aim%20of%20the%20present%20analysis%20is%20to%20investigate%20how%20interaction%20among%20patients%20and%20physicians%20affects%20the%20diffusion.%20We%20look%20at%20two%20different%20ways%20that%20patient%20pathways%20might%20influence%20physicians%20and%20examine%20these%20effects%20for%20Sacubitril%5C%2FValsartan%20%28S%5C%2FV%29%2C%20a%20new%20drug%20for%20patients%20with%20heart%20failure.%20Using%20administrative%20data%20from%20Germany%2C%20we%20identify%20physicians%20who%20prescribed%20S%5C%2FV%20in%20the%20first%202%5Cu00a0years%20of%20its%20availability.%20We%20apply%20survival%20models%20to%20estimate%20the%20impact%20of%20the%20patient-physician%20interaction%20on%20the%20physicians%26%23039%3B%20adoption%20time.%20To%20this%20end%2C%20we%20determine%20whether%20individual%20physicians%20treated%20patients%20that%20had%20been%20prescribed%20S%5C%2FV%2C%20and%20how%20many%20other%20physicians%20already%20prescribing%20S%5C%2FV%20were%20connected%20in%20patient-sharing%20networks.%20Our%20main%20findings%20are%20that%20patients%20with%20a%20previous%20prescription%20seem%20to%20induce%20adoption%20by%20demanding%20repeat%20prescriptions.%20Moreover%2C%20patients%20establish%20connections%20between%20physicians%20that%20may%20lead%20to%20prescriptions%20for%20new%20patients.%20Our%20results%20therefore%20suggest%20that%20patient%20pathways%20play%20a%20significant%20role%20in%20the%20diffusion%20of%20a%20new%20drug.%22%2C%22date%22%3A%222023-01-06%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1002%5C%2Fhec.4650%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221099-1050%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22R2J5Y2I9%22%2C%22SPWXRLZV%22%2C%22QXIGN3AI%22%2C%22P9CVNWVH%22%2C%22YT56KJXE%22%5D%2C%22dateModified%22%3A%222024-06-01T13%3A49%3A39Z%22%7D%7D%2C%7B%22key%22%3A%22LSZ9AXIT%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Dinh%20et%20al.%22%2C%22parsedDate%22%3A%222023%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BDinh%2C%20Truc%20Sophia%2C%20Andreas%20D.%20Meid%2C%20Henrik%20Rudolf%2C%20Maria-Sophie%20Brueckle%2C%20Ana%20I.%20Gonz%26%23xE1%3Blez-Gonz%26%23xE1%3Blez%2C%20Veronika%20Bencheva%2C%20Matthias%20Gogolin%2C%20et%20al.%20%26%23x201C%3BAnticholinergic%20Burden%20Measures%2C%20Symptoms%2C%20and%20Fall-Associated%20Risk%20in%20Older%20Adults%20with%20Polypharmacy%3A%20Development%20and%20Validation%20of%20a%20Prognostic%20Model.%26%23x201D%3B%20%26lt%3Bi%26gt%3BPloS%20One%26lt%3B%5C%2Fi%26gt%3B%2018%2C%20no.%201%20%282023%29%3A%20e0280907.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0280907%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1371%5C%2Fjournal.pone.0280907%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Anticholinergic%20burden%20measures%2C%20symptoms%2C%20and%20fall-associated%20risk%20in%20older%20adults%20with%20polypharmacy%3A%20Development%20and%20validation%20of%20a%20prognostic%20model%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Truc%20Sophia%22%2C%22lastName%22%3A%22Dinh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20D.%22%2C%22lastName%22%3A%22Meid%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henrik%22%2C%22lastName%22%3A%22Rudolf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria-Sophie%22%2C%22lastName%22%3A%22Brueckle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ana%20I.%22%2C%22lastName%22%3A%22Gonz%5Cu00e1lez-Gonz%5Cu00e1lez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Veronika%22%2C%22lastName%22%3A%22Bencheva%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Gogolin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kym%20I.%20E.%22%2C%22lastName%22%3A%22Snell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Petra%20J.%20M.%22%2C%22lastName%22%3A%22Elders%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Petra%20A.%22%2C%22lastName%22%3A%22Thuermann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeanet%20W.%22%2C%22lastName%22%3A%22Blom%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marjan%22%2C%22lastName%22%3A%22van%20den%20Akker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ferdinand%20M.%22%2C%22lastName%22%3A%22Gerlach%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastian%22%2C%22lastName%22%3A%22Harder%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ulrich%22%2C%22lastName%22%3A%22Thiem%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul%20P.%22%2C%22lastName%22%3A%22Glasziou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Walter%20E.%22%2C%22lastName%22%3A%22Haefeli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christiane%22%2C%22lastName%22%3A%22Muth%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Anticholinergic%20burden%20has%20been%20associated%20with%20adverse%20outcomes%20such%20as%20falls.%20To%20date%2C%20no%20gold%20standard%20measure%20has%20been%20identified%20to%20assess%20anticholinergic%20burden%2C%20and%20no%20conclusion%20has%20been%20drawn%20on%20which%20of%20the%20different%20measure%20algorithms%20best%20predicts%20falls%20in%20older%20patients%20from%20general%20practice.%20This%20study%20compared%20the%20ability%20of%20five%20measures%20of%20anticholinergic%20burden%20to%20predict%20falls.%20To%20account%20for%20patients%26%23039%3B%20individual%20susceptibility%20to%20medications%2C%20the%20added%20predictive%20value%20of%20typical%20anticholinergic%20symptoms%20was%20further%20quantified%20in%20this%20context.%5CnMETHODS%20AND%20FINDINGS%3A%20To%20predict%20falls%2C%20models%20were%20developed%20and%20validated%20based%20on%20logistic%20regression%20models%20created%20using%20data%20from%20two%20German%20cluster-randomized%20controlled%20trials.%20The%20outcome%20was%20defined%20as%20%26quot%3B%5Cu2265%201%20fall%26quot%3B%20vs.%20%26quot%3Bno%20fall%26quot%3B%20within%20a%206-month%20follow-up%20period.%20Data%20from%20the%20RIME%20study%20%28n%20%3D%201%2C197%29%20were%20used%20in%20model%20development%2C%20and%20from%20PRIMUM%20%28n%20%3D%20502%29%20for%20external%20validation.%20The%20models%20were%20developed%20step-wise%20in%20order%20to%20quantify%20the%20predictive%20ability%20of%20anticholinergic%20burden%20measures%2C%20and%20anticholinergic%20symptoms.%20In%20the%20development%20set%2C%201%2C015%20patients%20had%20complete%20data%20and%20188%20%2818.5%25%29%20experienced%20%5Cu2265%201%20fall%20within%20the%206-month%20follow-up%20period.%20The%20overall%20predictive%20value%20of%20the%20five%20anticholinergic%20measures%20was%20limited%2C%20with%20neither%20the%20employed%20anticholinergic%20variable%20%28binary%20%5C%2F%20count%20%5C%2F%20burden%29%2C%20nor%20dose-dependent%20or%20dose-independent%20measures%20differing%20significantly%20in%20their%20ability%20to%20predict%20falls.%20The%20highest%20c-statistic%20was%20obtained%20using%20the%20German%20Anticholinergic%20Burden%20Score%20%280.73%29%2C%20whereby%20the%20optimism-corrected%20c-statistic%20was%200.71%20after%20interval%20validation%20using%20bootstrapping%20and%200.63%20in%20the%20external%20validation.%20Previous%20falls%20and%20dizziness%20%5C%2F%20vertigo%20had%20the%20strongest%20prognostic%20value%20in%20all%20models.%5CnCONCLUSIONS%3A%20The%20ability%20of%20anticholinergic%20burden%20measures%20to%20predict%20falls%20does%20not%20appear%20to%20differ%20significantly%2C%20and%20the%20added%20value%20they%20contribute%20to%20risk%20classification%20in%20fall-prediction%20models%20is%20limited.%20Previous%20falls%20and%20dizziness%20%5C%2F%20vertigo%20contributed%20most%20to%20model%20performance.%22%2C%22date%22%3A%222023%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1371%5C%2Fjournal.pone.0280907%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221932-6203%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22IE7JTZ2W%22%2C%2246NNKHWR%22%2C%22R2J5Y2I9%22%5D%2C%22dateModified%22%3A%222024-03-11T09%3A12%3A17Z%22%7D%7D%2C%7B%22key%22%3A%223Y37599U%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Wegwarth%20et%20al.%22%2C%22parsedDate%22%3A%222022-10-26%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BWegwarth%2C%20Odette%2C%20Claudia%20Spies%2C%20Wolf-Dieter%20Ludwig%2C%20Norbert%20Donner-Banzhoff%2C%20G%26%23xFC%3Bnther%20Jonitz%2C%20and%20Ralph%20Hertwig.%20%26%23x201C%3BEducating%20Physicians%20on%20Strong%20Opioids%20by%20Descriptive%20versus%20Simulated-Experience%20Formats%3A%20A%20Randomized%20Controlled%20Trial.%26%23x201D%3B%20%26lt%3Bi%26gt%3BBMC%20Medical%20Education%26lt%3B%5C%2Fi%26gt%3B%2022%2C%20no.%201%20%28October%2026%2C%202022%29%3A%20741.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12909-022-03797-7%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12909-022-03797-7%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Educating%20physicians%20on%20strong%20opioids%20by%20descriptive%20versus%20simulated-experience%20formats%3A%20a%20randomized%20controlled%20trial%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Odette%22%2C%22lastName%22%3A%22Wegwarth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Spies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolf-Dieter%22%2C%22lastName%22%3A%22Ludwig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22G%5Cu00fcnther%22%2C%22lastName%22%3A%22Jonitz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ralph%22%2C%22lastName%22%3A%22Hertwig%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Long-term%20prescriptions%20of%20strong%20opioids%20for%20chronic%20noncancer%20pain-which%20are%20not%20supported%20by%20scientific%20evidence-suggest%20miscalibrated%20risk%20perceptions%20among%20those%20who%20prescribe%2C%20dispense%2C%20and%20take%20opioids.%20Because%20risk%20perceptions%20and%20behaviors%20can%20differ%20depending%20on%20whether%20people%20learn%20about%20risks%20through%20description%20or%20experience%2C%20we%20investigated%20the%20effects%20of%20descriptive%20versus%20simulated-experience%20educative%20formats%20on%20physicians%26%23039%3B%20risk%20perceptions%20of%20strong%20opioids%20and%20their%20prescription%20behavior%20for%20managing%20chronic%20noncancer%20pain.%5CnMETHODS%3A%20Three%20hundred%20general%20practitioners%20and%20300%20pain%20specialists%20in%20Germany-enrolled%20separately%20in%20two%20independent%20exploratory%20randomized%20controlled%20online%20trials-were%20randomly%20assigned%20to%20either%20a%20descriptive%20format%20%28fact%20box%29%20or%20a%20simulated-experience%20format%20%28interactive%20simulation%29.%5CnPRIMARY%20ENDPOINTS%3A%20Objective%20risk%20perception%20%28numerical%20estimates%20of%20opioids%26%23039%3B%20benefits%20and%20harms%29%2C%20actual%20prescriptions%20of%20seven%20therapy%20options%20for%20managing%20chronic%20pain.%5CnSECONDARY%20ENDPOINT%3A%20Implementation%20of%20intended%20prescriptions%20of%20seven%20therapy%20options%20for%20managing%20chronic%20pain.%5CnRESULTS%3A%20Both%20formats%20improved%20the%20proportion%20of%20correct%20numerical%20estimates%20of%20strong%20opioids%26%23039%3B%20benefits%20and%20harms%20immediately%20after%20intervention%2C%20with%20no%20notable%20differences%20between%20formats.%20Compared%20to%20description%2C%20simulated%20experience%20led%20to%20significantly%20lower%20reported%20actual%20prescription%20rates%20for%20strong%20and%5C%2For%20weak%20opioids%2C%20and%20was%20more%20effective%20at%20increasing%20prescription%20rates%20for%20non-drug-based%20therapies%20%28e.g.%2C%20means%20of%20opioid%20reduction%29%20from%20baseline%20to%20follow-up%20for%20both%20general%20practitioners%20and%20pain%20specialists.%20Simulated%20experience%20also%20resulted%20in%20a%20higher%20implementation%20of%20intended%20behavior%20for%20some%20drug-based%20and%20non-drug-based%20therapies.%5CnCONCLUSIONS%3A%20The%20two%20formats%2C%20which%20recruit%20different%20cognitive%20processes%2C%20may%20serve%20different%20risk-communication%20goals%3A%20If%20the%20goal%20is%20to%20improve%20exact%20risk%20perception%2C%20descriptive%20and%20simulated-experience%20formats%20are%20likely%20to%20be%20equally%20suitable.%20If%2C%20however%2C%20the%20goal%20is%20to%20boost%20less%20risky%20prescription%20habits%2C%20simulated%20experience%20may%20be%20the%20better%20choice.%5CnTRIAL%20REGISTRATION%3A%20DRKS00020358%20%28German%20Clinical%20Trials%20Register%2C%20first%20registration%3A%2007%5C%2F01%5C%2F2020%29.%22%2C%22date%22%3A%222022-10-26%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12909-022-03797-7%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221472-6920%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22R2J5Y2I9%22%2C%22SPWXRLZV%22%2C%22QXIGN3AI%22%2C%22W637CI9M%22%2C%22P9CVNWVH%22%5D%2C%22dateModified%22%3A%222024-05-15T13%3A52%3A00Z%22%7D%7D%2C%7B%22key%22%3A%22LAZW376A%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Michiels-Corsten%20et%20al.%22%2C%22parsedDate%22%3A%222022-09-26%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMichiels-Corsten%2C%20Matthias%2C%20Navina%20Gerlach%2C%20Ulrike%20Junius-Walker%2C%20Tanja%20Schleef%2C%20Norbert%20Donner-Banzhoff%2C%20and%20Annika%20Viniol.%20%26%23x201C%3BMediQuit%20-%20an%20Electronic%20Deprescribing%20Tool%3A%20A%20Pilot%20Study%20in%20German%20Primary%20Care%3B%20GPs%26%23x2019%3B%20and%20Patients%26%23x2019%3B%20Perspectives.%26%23x201D%3B%20%26lt%3Bi%26gt%3BBMC%20Primary%20Care%26lt%3B%5C%2Fi%26gt%3B%2023%2C%20no.%201%20%28September%2026%2C%202022%29%3A%20252.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12875-022-01852-2%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12875-022-01852-2%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22MediQuit%20-%20an%20electronic%20deprescribing%20tool%3A%20a%20pilot%20study%20in%20German%20primary%20care%3B%20GPs%27%20and%20patients%27%20perspectives%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Michiels-Corsten%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Navina%22%2C%22lastName%22%3A%22Gerlach%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ulrike%22%2C%22lastName%22%3A%22Junius-Walker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tanja%22%2C%22lastName%22%3A%22Schleef%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annika%22%2C%22lastName%22%3A%22Viniol%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20General%20practitioners%20%28GPs%29%20are%20the%20central%20coordinators%20for%20patients%20with%20multimorbidity%20and%20polypharmacy%20in%20most%20health%20care%20systems.%20They%20are%20entrusted%20with%20the%20challenging%20task%20of%20deprescribing%20when%20inappropriate%20polypharmacy%20is%20present.%20MediQuit%20%28MQu%29%20is%20a%20newly%20developed%20electronic%20tool%20that%20guides%20through%20a%20deprescribing%20consultation.%20It%20facilitates%20the%20identification%20of%20a%20medicine%20to%20be%20discontinued%20%28stage%201%29%2C%20a%20shared%20decision-making%20process%20weighing%20the%20pros%20and%20cons%20%28stage%202%29%2C%20and%20equips%20patients%20with%20take-home%20instructions%20on%20how%20to%20discontinue%20the%20drug%20and%20monitor%20its%20impact%20%28stage%203%29.%20We%20here%20aim%20to%20evaluate%20utility%20and%20acceptance%20of%20MQu%20from%20GPs%26%23039%3B%20and%20patients%26%23039%3B%20perspectives.%5CnMETHODS%3A%20Uncontrolled%20feasibility%20study%2C%20in%20which%2016%20GPs%20from%20two%20regions%20in%20Germany%20were%20invited%20to%20use%20MQu%20in%20consultations%20with%20their%20multimorbid%20patients.%20We%20collected%20quantitative%20data%20on%20demography%2C%20utility%20and%20acceptance%20of%20MQu%20and%20performed%20descriptive%20statistical%20analyses.%5CnRESULTS%3A%20Ten%20GPs%20performed%2041%20consultations%20using%20MQu.%20Identification%20%28step%201%29%20and%20implementation%20elements%20%28Step%203%29%20were%20perceived%20most%20helpful%20by%20GPs.%20Whereas%2C%20shared-decision%20making%20elements%20%28step%202%29%20revealed%20room%20for%20improvement.%20Patients%20appreciated%20the%20use%20of%20MQu.%20They%20were%20broadly%20satisfied%20with%20the%20deprescribing%20consultation%20%2885%25%29%20and%20with%20their%20decision%20made%20regarding%20their%20medication%20%2890%25%29.%5CnCONCLUSIONS%3A%20Implementation%20of%20MQu%20in%20general%20practice%20generally%20seems%20possible.%20Patients%20welcome%20consultations%20targeting%20medication%20optimization.%20GPs%20were%20satisfied%20with%20the%20support%20of%20MQu%20and%20likewise%20gave%20important%20hints%20for%20future%20development.%22%2C%22date%22%3A%222022-09-26%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12875-022-01852-2%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222731-4553%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22ZFT52UPQ%22%2C%22IE7JTZ2W%22%2C%2246NNKHWR%22%2C%22R2J5Y2I9%22%2C%22P9CVNWVH%22%5D%2C%22dateModified%22%3A%222024-03-11T09%3A11%3A56Z%22%7D%7D%2C%7B%22key%22%3A%22ABAWUIVH%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Novelli%20et%20al.%22%2C%22parsedDate%22%3A%222022-08-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BNovelli%2C%20Anna%2C%20Julia%20Frank-Tewaag%2C%20Julian%20Bleek%2C%20Christian%20G%26%23xFC%3Bnster%2C%20Udo%20Schneider%2C%20Ursula%20Marschall%2C%20Kathrin%20Schl%26%23xF6%3B%26%23xDF%3Bler%2C%20Norbert%20Donner-Banzhoff%2C%20and%20Leonie%20Sundmacher.%20%26%23x201C%3BIdentifying%20and%20Investigating%20Ambulatory%20Care%20Sequences%20Before%20Invasive%20Coronary%20Angiography.%26%23x201D%3B%20%26lt%3Bi%26gt%3BMedical%20Care%26lt%3B%5C%2Fi%26gt%3B%2060%2C%20no.%208%20%28August%201%2C%202022%29%3A%20602%26%23x2013%3B9.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FMLR.0000000000001738%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1097%5C%2FMLR.0000000000001738%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Identifying%20and%20Investigating%20Ambulatory%20Care%20Sequences%20Before%20Invasive%20Coronary%20Angiography%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna%22%2C%22lastName%22%3A%22Novelli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Frank-Tewaag%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julian%22%2C%22lastName%22%3A%22Bleek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christian%22%2C%22lastName%22%3A%22G%5Cu00fcnster%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Udo%22%2C%22lastName%22%3A%22Schneider%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ursula%22%2C%22lastName%22%3A%22Marschall%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22Schl%5Cu00f6%5Cu00dfler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leonie%22%2C%22lastName%22%3A%22Sundmacher%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20The%20concept%20of%20care%20pathways%20is%20widely%20used%20to%20provide%20efficient%2C%20timely%2C%20and%20evidence-based%20medical%20care.%20Recently%2C%20the%20investigation%20of%20actual%20empirical%20patient%20pathways%20has%20gained%20attention.%20We%20demonstrate%20the%20usability%20of%20State%20Sequence%20Analysis%20%28SSA%29%2C%20a%20data%20mining%20approach%20based%20on%20sequence%20clustering%20techniques%2C%20on%20comprehensive%20insurance%20claims%20data%20from%20Germany%20to%20identify%20empirical%20ambulatory%20care%20sequences.%20We%20investigate%20patients%20with%20coronary%20artery%20disease%20before%20invasive%20coronary%20angiography%20%28CA%29%20and%20compare%20identified%20patterns%20with%20guideline%20recommendations.%20This%20patient%20group%20is%20of%20particular%20interest%20due%20to%20high%20and%20regionally%20varying%20CA%20rates.%5CnMETHODS%3A%20Events%20relevant%20for%20the%20care%20of%20coronary%20artery%20disease%20patients%2C%20namely%20physician%20consultations%20and%20medication%20prescriptions%2C%20are%20identified%20based%20on%20medical%20guidelines%20and%20combined%20to%20define%20states.%20State%20sequences%20are%20determined%20for%201.5%20years%20before%20CA.%20Sequence%20similarity%20is%20defined%20for%20clustering%2C%20using%20optimal%20matching%20with%20theory-informed%20substitution%20costs.%20We%20visualize%20clusters%2C%20present%20descriptive%20statistics%2C%20and%20apply%20logistic%20regression%20to%20investigate%20the%20association%20of%20cluster%20membership%20with%20subsequent%20undesired%20care%20events.%5CnRESULTS%3A%20Five%20clusters%20are%20identified%2C%20the%20included%20patients%20differing%20with%20respect%20to%20morbidity%2C%20urbanity%20of%20residential%20area%2C%20and%20health%20care%20utilization.%20Clusters%20exhibit%20significant%20differences%20in%20the%20timing%2C%20structure%2C%20and%20extent%20of%20care%20before%20CA.%20When%20compared%20with%20guideline%20recommendations%2C%203%20clusters%20show%20signs%20of%20care%20deficits.%5CnCONCLUSIONS%3A%20Our%20analyses%20demonstrate%20the%20potential%20of%20SSA%20for%20exploratory%20health%20care%20research.%20We%20show%20how%20SSA%20can%20be%20used%20on%20insurance%20claims%20data%20to%20identify%2C%20visualize%2C%20and%20investigate%20care%20patterns%20and%20their%20deviations%20from%20guideline%20recommendations.%22%2C%22date%22%3A%222022-08-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1097%5C%2FMLR.0000000000001738%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221537-1948%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22R2J5Y2I9%22%2C%22X7PUUBWP%22%2C%22SPWXRLZV%22%2C%22QXIGN3AI%22%2C%228B2HH96K%22%2C%22P9CVNWVH%22%2C%22YT56KJXE%22%5D%2C%22dateModified%22%3A%222025-05-18T07%3A49%3A29Z%22%7D%7D%2C%7B%22key%22%3A%229VNI9CSI%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Angelow%20et%20al.%22%2C%22parsedDate%22%3A%222022-07-11%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BAngelow%2C%20Aniela%2C%20Christine%20Kl%26%23xF6%3Btzer%2C%20Norbert%20Donner-Banzhoff%2C%20J%26%23xF6%3Brg%20Haasenritter%2C%20Carsten%20Oliver%20Schmidt%2C%20Marcus%20D%26%23xF6%3Brr%2C%20and%20Jean-Fran%26%23xE7%3Bois%20Chenot.%20%26%23x201C%3BValidation%20of%20Cardiovascular%20Risk%20Prediction%20by%20the%20Arriba%20Instrument.%26%23x201D%3B%20%26lt%3Bi%26gt%3BDeutsches%20Arzteblatt%20International%26lt%3B%5C%2Fi%26gt%3B%20119%2C%20no.%2027%26%23x2013%3B28%20%28July%2011%2C%202022%29%3A%20476%26%23x2013%3B82.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3238%5C%2Farztebl.m2022.0220%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3238%5C%2Farztebl.m2022.0220%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Validation%20of%20Cardiovascular%20Risk%20Prediction%20by%20the%20Arriba%20Instrument%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Aniela%22%2C%22lastName%22%3A%22Angelow%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christine%22%2C%22lastName%22%3A%22Kl%5Cu00f6tzer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00f6rg%22%2C%22lastName%22%3A%22Haasenritter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carsten%20Oliver%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marcus%22%2C%22lastName%22%3A%22D%5Cu00f6rr%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jean-Fran%5Cu00e7ois%22%2C%22lastName%22%3A%22Chenot%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20It%20is%20recommended%20in%20cardiovascular%20prevention%20guidelines%20that%20treatment%20should%20be%20based%20on%20overall%20cardiovascular%20risk.%20The%20arriba%20instrument%20has%20been%20widely%20used%20for%20this%20purpose%20in%20Germany.%20The%20aim%20of%20this%20study%20is%20to%20validate%20risk%20prediction%20by%20arriba%20with%20the%20aid%20of%20morbidity%20and%20mortality%20data%20from%20the%20population-%20based%20Study%20of%20Health%20in%20Pomerania.%5CnMETHODS%3A%20In%20a%20longitudinal%20analysis%2C%20the%20arriba%20instrument%20was%20used%20to%20calculate%20the%2010-year%20overall%20cardiovascular%20risk%20at%20baseline%20for%20subjects%20who%20had%20not%20sustained%20any%20prior%20cardiovascular%20event.%20Cardiovascular%20event%20rates%20were%20determined%20from%20follow-up%20data%2C%20and%20discrimination%20and%20calibration%20measures%20for%20the%20risk%20determination%20algorithm%20were%20calculated.%5CnRESULTS%3A%20Data%20from%201973%20subjects%20%28mean%20age%2051%20%5Cu00b1%2013%20years%2C%2048%25%20men%29%20were%20included%20in%20the%20analysis.%20After%20a%20median%20follow-up%20of%2010.9%20years%2C%20cardiovascular%20events%20had%20occurred%20in%20196%20subjects%2C%20or%209.8%25.%20The%20ratio%20of%20predicted%20to%20observed%20event%20rate%20was%200.8%20%2895%25%20confidence%20interval%3A%20%5B0.5%3B%201.1%5D%29%2C%201.3%20%5B1.0%3B%201.8%5D%2C%20and%201.1%20%5B0.8%3B%201.4%5D%20for%20subjects%20at%20low%2C%20intermediate%2C%20and%20high%20cardiovascular%20risk%2C%20respectively.%20Arriba%20underestimated%20cardiovascular%20event%20rates%20in%20women%20and%20overestimated%20them%20in%20persons%20aged%2030-44%20and%2045-59.%20The%20area%20under%20curve%20was%200.84%20%5B95%25%20CI%200.81%3B%200.86%5D.%5CnCONCLUSION%3A%20The%20discrimination%20scores%20of%20the%20arriba%20instrument%20resemble%20those%20of%20SCORE-Germany%20and%20PROCAM%2C%20but%20a%20better%20adjustment%20to%20the%20target%20population%20would%20be%20desirable.%20The%20results%20support%20the%20recommendation%20of%20the%20German%20Guideline%20for%20Cardiovascular%20Risk%20Counseling%20in%20General%20Practice%20for%20the%20use%20of%20the%20arriba%20instrument.%20An%20unresolved%20problem%20is%20the%20failure%20to%20consider%20intervention%20effects%2C%20resulting%20in%20an%20overall%20mild%20overestimation%20of%20risk.%22%2C%22date%22%3A%222022-07-11%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.3238%5C%2Farztebl.m2022.0220%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221866-0452%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22IE7JTZ2W%22%2C%2246NNKHWR%22%2C%22R2J5Y2I9%22%2C%22SPWXRLZV%22%2C%22SG8SD8IJ%22%2C%22QXIGN3AI%22%2C%224KVK6YUS%22%2C%22P9CVNWVH%22%2C%226CWITS3E%22%5D%2C%22dateModified%22%3A%222024-03-11T09%3A12%3A12Z%22%7D%7D%2C%7B%22key%22%3A%228HE7VVYW%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Hahlweg%20et%20al.%22%2C%22parsedDate%22%3A%222022-06%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BHahlweg%2C%20Pola%2C%20Christiane%20Bieber%2C%20Anna%20Levke%20Br%26%23xFC%3Btt%2C%20Marie-Luise%20Dierks%2C%20J%26%23xF6%3Brg%20Dirmaier%2C%20Norbert%20Donner-Banzhoff%2C%20Wolfgang%20Eich%2C%20et%20al.%20%26%23x201C%3BMoving%20towards%20Patient-Centered%20Care%20and%20Shared%20Decision-Making%20in%20Germany.%26%23x201D%3B%20%26lt%3Bi%26gt%3BZeitschrift%20Fur%20Evidenz%2C%20Fortbildung%20Und%20Qualitat%20Im%20Gesundheitswesen%26lt%3B%5C%2Fi%26gt%3B%20171%20%28June%202022%29%3A%2049%26%23x2013%3B57.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.zefq.2022.04.001%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.zefq.2022.04.001%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Moving%20towards%20patient-centered%20care%20and%20shared%20decision-making%20in%20Germany%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pola%22%2C%22lastName%22%3A%22Hahlweg%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christiane%22%2C%22lastName%22%3A%22Bieber%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna%22%2C%22lastName%22%3A%22Levke%20Br%5Cu00fctt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marie-Luise%22%2C%22lastName%22%3A%22Dierks%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00f6rg%22%2C%22lastName%22%3A%22Dirmaier%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Eich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Friedemann%22%2C%22lastName%22%3A%22Geiger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%22%2C%22lastName%22%3A%22Klemperer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Koch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mirjam%22%2C%22lastName%22%3A%22K%5Cu00f6rner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hardy%22%2C%22lastName%22%3A%22M%5Cu00fcller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Isabelle%22%2C%22lastName%22%3A%22Scholl%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martin%22%2C%22lastName%22%3A%22H%5Cu00e4rter%22%7D%5D%2C%22abstractNote%22%3A%22The%20main%20focus%20of%20this%20paper%20is%20to%20describe%20the%20development%20and%20current%20state%20of%20policy%2C%20research%20and%20implementation%20of%20patient-centered%20care%20%28PCC%29%20and%20shared%20decision-making%20%28SDM%29%20in%20Germany.%20What%20is%20the%20current%20state%20in%20health%20policy%3F%20Since%202013%2C%20the%20Law%20on%20Patients%26%23039%3B%20Rights%20has%20standardized%20all%20rights%20and%20responsibilities%20regarding%20medical%20care%20for%20patients%20in%20Germany.%20This%20comprises%20the%20right%20to%20informed%20decisions%2C%20comprehensive%20and%20comprehensible%20information%2C%20and%20decisions%20based%20on%20a%20clinician-patient%20partnership.%20In%20addition%2C%20reports%20and%20action%20plans%20such%20as%20the%20German%20Ethics%20Council%26%23039%3Bs%20report%20on%20patient%20well-being%2C%20the%20National%20Health%20Literacy%20Action%20Plan%2C%20or%20the%20National%20Cancer%20Plan%20emphasize%20and%20foster%20PCC%20and%20SDM%20on%20a%20policy%20level.%20There%20are%20a%20number%20of%20public%20organizations%20in%20Germany%20that%20support%20PCC%20and%20SDM.%20How%20are%20patients%20and%20the%20public%20involved%20in%20health%20policy%20and%20research%3F%20Publishers%20and%20funding%20agencies%20increasingly%20demand%20patient%20and%20public%20involvement.%20Numerous%20initiatives%20and%20organizations%20are%20involved%20in%20publicizing%20ways%20to%20engage%20patients%20and%20the%20public.%20Also%2C%20an%20increasing%20number%20of%20public%20and%20research%20institutions%20have%20established%20patient%20advisory%20boards.%20How%20is%20PCC%20and%20SDM%20taught%3F%20Great%20progress%20has%20been%20made%20in%20introducing%20SDM%20into%20the%20curricula%20of%20medical%20schools%20and%20other%20health%20care%20providers%26%23039%3B%20%28HCPs%29%20schools%20%28e.g.%2C%20nursing%2C%20physical%20therapy%29.%20What%20is%20the%20German%20research%20agenda%3F%20The%20German%20government%20and%20other%20public%20institutions%20have%20constantly%20funded%20research%20programs%20in%20which%20PCC%20and%20SDM%20are%20important%20topics.%20This%20yielded%20several%20large-scale%20funding%20initiatives%20and%20helped%20to%20develop%20SDM%20training%20programs%20for%20HCPs%20in%20different%20fields%20of%20health%20care%20and%20information%20materials.%20Recently%2C%20two%20implementation%20studies%20on%20SDM%20have%20been%20conducted.%20What%20is%20the%20current%20uptake%20of%20PCC%20and%20SDM%20in%20routine%20care%2C%20and%20what%20implementation%20efforts%20are%20underway%3F%20Compared%20to%20the%20last%20country%20report%20from%202017%2C%20PCC%20and%20SDM%20efforts%20in%20policy%2C%20research%20and%20education%20have%20been%20intensified.%20However%2C%20many%20steps%20are%20still%20needed%20to%20reliably%20implement%20SDM%20in%20routine%20care%20in%20Germany.%20Specifically%2C%20the%20further%20development%20and%20uptake%20of%20decision%20tools%20and%20countrywide%20SDM%20trainings%20for%20HCPs%20require%20further%20efforts.%20Nevertheless%2C%20an%20increasing%20number%20of%20decision%20support%20tools%20-%20primarily%20with%20support%20from%20health%20insurance%20funds%20and%20other%20public%20agencies%20-%20are%20to%20be%20implemented%20in%20routine%20care.%20Also%2C%20recent%20implementation%20efforts%20are%20promising.%20For%20example%2C%20reimbursement%20by%20health%20insurance%20companies%20of%20hospital-wide%20SDM%20implementation%20is%20being%20piloted.%20A%20necessary%20next%20step%20is%20to%20nationally%20coordinate%20the%20gathering%20and%20provision%20of%20the%20many%20PCC%20and%20SDM%20resources%20available.%22%2C%22date%22%3A%222022-06%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.zefq.2022.04.001%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222212-0289%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22ZFT52UPQ%22%2C%22IE7JTZ2W%22%2C%2246NNKHWR%22%2C%22DCJX59XL%22%2C%22Z9T7PLDJ%22%2C%22R2J5Y2I9%22%2C%22X7PUUBWP%22%2C%22SPWXRLZV%22%2C%22W637CI9M%22%2C%22JL4N5KDE%22%2C%22P9CVNWVH%22%2C%22WK7W2JLX%22%2C%22Z4HUV5DA%22%2C%2272HALNLA%22%5D%2C%22dateModified%22%3A%222024-05-27T14%3A34%3A18Z%22%7D%7D%2C%7B%22key%22%3A%22L3MNLSNZ%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Michiels-Corsten%20et%20al.%22%2C%22parsedDate%22%3A%222022-05-28%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMichiels-Corsten%2C%20Matthias%2C%20Anna%20M.%20Weyand%2C%20Judith%20Gold%2C%20Stefan%20B%26%23xF6%3Bsner%2C%20and%20Norbert%20Donner-Banzhoff.%20%26%23x201C%3BInductive%20Foraging%3A%20Patients%20Taking%20the%20Lead%20in%20Diagnosis%2C%20a%20Mixed-Methods%20Study.%26%23x201D%3B%20%26lt%3Bi%26gt%3BFamily%20Practice%26lt%3B%5C%2Fi%26gt%3B%2039%2C%20no.%203%20%28May%2028%2C%202022%29%3A%20479%26%23x2013%3B85.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Ffampra%5C%2Fcmab144%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Ffampra%5C%2Fcmab144%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Inductive%20foraging%3A%20patients%20taking%20the%20lead%20in%20diagnosis%2C%20a%20mixed-methods%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Michiels-Corsten%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anna%20M.%22%2C%22lastName%22%3A%22Weyand%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Judith%22%2C%22lastName%22%3A%22Gold%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22B%5Cu00f6sner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Patient%20involvement%20in%20treatment%20decisions%20is%20widely%20accepted.%20Making%20a%20diagnosis%2C%20however%2C%20is%20still%20seen%20as%20a%20technical%20task%20mainly%20driven%20by%20physicians.%20Patients%20in%20this%20respect%20are%20perceived%20as%20passive%20providers%20of%20data.%20But%2C%20recent%20patient-centred%20concepts%20highlight%20the%20value%20of%20an%20active%20patient%20involvement%20in%20diagnosis.%5CnOBJECTIVE%3A%20We%20aim%20to%20reach%20a%20deeper%20understanding%20of%20how%20patients%20themselves%20contribute%20to%20the%20diagnostic%20process.%5CnMETHODS%3A%20This%20is%20an%20observational%20study%20of%20patient%20consultations%20with%20their%20General%20Practitioner%20%28GP%29%20in%2012%20German%20practices.%20We%20performed%20a%20mixed-method%20qualitative%20and%20quantitative%20analysis%20of%20134%20primary%20care%20consultations.%5CnRESULTS%3A%20At%20the%20beginning%20of%20most%20consultations%20lies%20a%20phase%20where%20patients%20were%20invited%20to%20freely%20unfold%20their%20reason%20for%20encounter%3A%20This%20was%20named%20%26quot%3Binductive%20foraging%26quot%3B%20%28IF%29.%20While%20patients%20actively%20present%20their%20complaints%2C%20GPs%20mainly%20listen%20and%20follow%20the%20presentation.%20This%20episode%20was%20found%20with%20every%20GP%20participating%20in%20this%20study.%20Ninety-one%20percent%20of%20consultations%20with%20diagnostic%20episodes%20were%20opened%20by%20IF.%20IF%20had%20a%20major%20contribution%20to%20the%20number%20of%20cues%20%28diagnostic%20information%29%20yielded%20in%20the%20diagnostic%20process.%20We%20illustrate%20a%20variety%20of%20tactics%20GPs%20make%20use%20of%20to%20invite%2C%20support%2C%20and%20terminate%20their%20patients%20in%20IF.%5CnCONCLUSION%3A%20IF%20was%20found%20to%20be%20a%20highly%20relevant%20strategy%20in%20the%20diagnostic%20process.%20Patient%20involvement%20through%20IF%20offered%20a%20major%20contribution%20of%20diagnostic%20cues.%20We%20hypothesize%20that%20a%20patient-centred%20approach%20improves%20diagnosis.%22%2C%22date%22%3A%222022-05-28%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1093%5C%2Ffampra%5C%2Fcmab144%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221460-2229%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22R2J5Y2I9%22%2C%22X7PUUBWP%22%2C%22SPWXRLZV%22%2C%22QXIGN3AI%22%5D%2C%22dateModified%22%3A%222024-03-11T09%3A12%3A02Z%22%7D%7D%2C%7B%22key%22%3A%22V86I5RJF%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Schulte%20et%20al.%22%2C%22parsedDate%22%3A%222022-04-29%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BSchulte%2C%20Erika%2C%20Frank%20Petzke%2C%20Claudia%20Spies%2C%20Claudia%20Denke%2C%20Michael%20Sch%26%23xE4%3Bfer%2C%20Norbert%20Donner-Banzhoff%2C%20Ralph%20Hertwig%2C%20and%20Odette%20Wegwarth.%20%26%23x201C%3BSelf-Reported%20Practices%20and%20Emotions%20in%20Prescribing%20Opioids%20for%20Chronic%20Noncancer%20Pain%3A%20A%20Cross-Sectional%20Study%20of%20German%20Physicians.%26%23x201D%3B%20%26lt%3Bi%26gt%3BJournal%20of%20Clinical%20Medicine%26lt%3B%5C%2Fi%26gt%3B%2011%2C%20no.%209%20%28April%2029%2C%202022%29%3A%202506.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fjcm11092506%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fjcm11092506%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Self-Reported%20Practices%20and%20Emotions%20in%20Prescribing%20Opioids%20for%20Chronic%20Noncancer%20Pain%3A%20A%20Cross-Sectional%20Study%20of%20German%20Physicians%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erika%22%2C%22lastName%22%3A%22Schulte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frank%22%2C%22lastName%22%3A%22Petzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Spies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Denke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Sch%5Cu00e4fer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ralph%22%2C%22lastName%22%3A%22Hertwig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Odette%22%2C%22lastName%22%3A%22Wegwarth%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20The%20pressure%20on%20physicians%20when%20a%20patient%20seeks%20pain%20relief%20and%20their%20own%20desire%20to%20be%20self-effective%20may%20lead%20to%20the%20prescription%20of%20strong%20opioids%20for%20chronic%20noncancer%20pain%20%28CNCP%29.%20This%20study%2C%20via%20physician%20self-reporting%2C%20aims%20to%20identify%20and%20measure%20%28i%29%20physician%20adherence%20to%20national%20opioid%20prescribing%20guidelines%20and%20%28ii%29%20physician%20emotions%20when%20a%20patient%20seeks%20a%20dosage%20increase%20of%20the%20opioid.%5CnMETHODS%3A%20Within%20a%20cross-sectional%20survey-conducted%20as%20part%20of%20a%20randomized%20controlled%20online%20intervention%20trial%20%28ERONA%29-600%20German%20physicians%20were%20queried%20on%20their%20opioid%20prescribing%20behavior%20%28choice%20and%20formulation%20of%20opioid%2C%20indications%29%20for%20CNCP%20patients%20and%20their%20emotions%20to%20a%20case%20vignette%20describing%20a%20patient%20seeking%20an%20opioid%20dosage%20increase%20without%20signs%20of%20objective%20deterioration.%5CnRESULTS%3A%20The%20prescription%20of%20strong%20opioids%20in%20this%20study%20was%20not%20always%20in%20accordance%20with%20current%20guidelines.%20When%20presented%20with%20a%20scenario%20in%20which%20a%20patient%20sought%20to%20have%20their%20opioid%20dose%20increased%2C%20some%20physicians%20reported%20negative%20feelings%2C%20such%20as%20either%20pressure%20%2825%25%29%2C%20helplessness%20%2825%25%29%2C%20anger%20%2823%25%29%20or%20a%20combination.%20The%20risk%20of%20non-guideline-compliant%20prescribing%20behavior%20using%20the%20example%20of%20ultrafast-acting%20fentanyl%20for%20CNCP%20was%20increased%20when%20negative%20emotions%20were%20present%20%28OR%3A%201.7%3B%2095%25-CI%3A%201.2-2.6%3B%20p%20%3D%200.007%29%20or%20when%20sublingual%20buprenorphine%20was%20prescribed%20%28OR%3A%2015.4%3B%2095%25-CI%3A%2010.1-23.3%3B%20p%20%26lt%3B%200.001%29.%5CnCONCLUSIONS%3A%20Physicians%26%23039%3B%20emotional%20self-awareness%20represents%20the%20first%20step%20to%20identify%20such%20direct%20reactions%20to%20patient%20requests%20and%20to%20ensure%20a%20responsible%2C%20guideline-based%20opioid%20prescription%20approach%20for%20the%20long-term%20well-being%20of%20the%20patient.%22%2C%22date%22%3A%222022-04-29%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.3390%5C%2Fjcm11092506%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222077-0383%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22R2J5Y2I9%22%2C%22SPWXRLZV%22%2C%22QXIGN3AI%22%2C%224KVK6YUS%22%2C%22W637CI9M%22%5D%2C%22dateModified%22%3A%222024-05-15T14%3A23%3A11Z%22%7D%7D%2C%7B%22key%22%3A%22SQWGD89U%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Frank-Tewaag%20et%20al.%22%2C%22parsedDate%22%3A%222022-02-26%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BFrank-Tewaag%2C%20Julia%2C%20Julian%20Bleek%2C%20Christian%20G%26%23xFC%3Bnster%2C%20Udo%20Schneider%2C%20Dirk%20Horenkamp-Sonntag%2C%20Ursula%20Marschall%2C%20Sebastian%20Franke%2C%20Kathrin%20Schl%26%23xF6%3B%26%23xDF%3Bler%2C%20Norbert%20Donner-Banzhoff%2C%20and%20Leonie%20Sundmacher.%20%26%23x201C%3BRegional%20Variation%20in%20Coronary%20Angiography%20Rates%3A%20The%20Association%20with%20Supply%20Factors%20and%20the%20Role%20of%20Indication%3A%20A%20Spatial%20Analysis.%26%23x201D%3B%20%26lt%3Bi%26gt%3BBMC%20Cardiovascular%20Disorders%26lt%3B%5C%2Fi%26gt%3B%2022%2C%20no.%201%20%28February%2026%2C%202022%29%3A%2072.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12872-022-02513-z%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12872-022-02513-z%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Regional%20variation%20in%20coronary%20angiography%20rates%3A%20the%20association%20with%20supply%20factors%20and%20the%20role%20of%20indication%3A%20a%20spatial%20analysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Frank-Tewaag%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julian%22%2C%22lastName%22%3A%22Bleek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christian%22%2C%22lastName%22%3A%22G%5Cu00fcnster%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Udo%22%2C%22lastName%22%3A%22Schneider%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dirk%22%2C%22lastName%22%3A%22Horenkamp-Sonntag%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ursula%22%2C%22lastName%22%3A%22Marschall%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastian%22%2C%22lastName%22%3A%22Franke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22Schl%5Cu00f6%5Cu00dfler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leonie%22%2C%22lastName%22%3A%22Sundmacher%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Coronary%20angiographies%20%28CAs%29%20are%20among%20the%20most%20common%20diagnostic%20procedures%20carried%20out%20in%20German%20hospitals%2C%20and%20substantial%20regional%20differences%20in%20their%20frequency%20of%20use%20have%20been%20documented.%20Given%20the%20heterogeneity%20with%20regard%20to%20the%20expected%20benefits%20and%20the%20varying%20scope%20for%20discretion%20depending%20on%20the%20indication%20for%20the%20procedure%2C%20we%20hypothesized%20that%20the%20observed%20variation%20and%20the%20association%20of%20need%20and%20supply%20factors%20differs%20by%20indication%20for%20CA.%5CnMETHODS%3A%20We%20investigated%20the%20correlation%20between%20supply%20factors%20and%20the%20regional%20rates%20of%20CAs%20in%20Germany%20while%20controlling%20for%20need%20using%20spatial-autoregressive%20error%20models%20%28SARE%29%20and%20spatial%20cross-regressive%20models%20with%20autoregressive%20errors%20%28SCRARE%29.%20The%20overall%20rates%20of%20CAs%20and%20the%20rates%20in%20specific%20patient%20subgroups%2C%20namely%2C%20patients%20with%20and%20without%20myocardial%20infarction%20%28MI%29%2C%20were%20calculated%20based%20on%20a%20comprehensive%20set%20of%20nationwide%20routine%20data%20from%20three%20statutory%20health%20insurances%20at%20the%20district%20level.%5CnRESULTS%3A%20Although%20little%20variation%20was%20found%20in%20cases%20with%20MI%2C%20considerable%20variation%20was%20seen%20in%20the%20overall%20cases%20and%20cases%20without%20MI.%20The%20SARE%20models%20revealed%20a%20positive%20association%20between%20the%20number%20of%20hospitals%20with%20a%20cardiac%20catheterization%20laboratory%20per%2010%2C000%20population%20and%20the%20rates%20of%20overall%20cases%20and%20cases%20without%20MI%2C%20whereas%20no%20such%20relationship%20existed%20in%20cases%20with%20MI.%20Additionally%2C%20an%20association%20between%20regional%20deprivation%20and%20the%20rates%20of%20CAs%20was%20found%20in%20cases%20with%20MI%2C%20but%20no%20such%20association%20was%20seen%20in%20cases%20without%20MI.%5CnCONCLUSIONS%3A%20The%20results%20supported%20the%20hypothesis%20that%20the%20relative%20association%20of%20need%20and%20supply%20factors%20differed%20by%20the%20indication%20for%20CA.%20Although%20the%20regional%20differences%20in%20the%20frequency%20of%20use%20of%20CAs%20can%20only%20be%20explained%20in%20part%20by%20the%20factors%20examined%20in%20our%20study%2C%20it%20offers%20insight%20into%20patient%20access%20to%20and%20the%20provision%20of%20CA%20services%20and%20can%20provide%20a%20platform%20for%20further%20local%20research.%22%2C%22date%22%3A%222022-02-26%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12872-022-02513-z%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221471-2261%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22R2J5Y2I9%22%2C%22X7PUUBWP%22%2C%22SPWXRLZV%22%2C%22QXIGN3AI%22%2C%22P9CVNWVH%22%5D%2C%22dateModified%22%3A%222024-03-11T09%3A11%3A41Z%22%7D%7D%2C%7B%22key%22%3A%22KYI2Y3XN%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zeschick%20et%20al.%22%2C%22parsedDate%22%3A%222022%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BZeschick%2C%20Nikoletta%2C%20Julia%20Gollnick%2C%20Julia%20Muth%2C%20Franziska%20H%5Cu00f6rbrand%2C%20Peter%20Killian%2C%20Wolfgang%20Krombholz%2C%20Norbert%20Donner-Banzhoff%2C%20Thomas%20K%5Cu00fchlein%2C%20and%20Maria%20Sebasti%5Cu00e3o.%20%26quot%3BVerordnungsverhalten%20von%20bayerischen%20Haus%5Cu00e4rzt%2Ainnen%20an%20der%20station%5Cu00e4r-ambulanten%20Schnittstelle%20vor%20dem%20Hintergrund%20der%20Bayerischen%20Wirkstoffvereinbarung%20%5Cu2013%20Qualitative%20Ergebnisse%20der%20WirtMed-Studie.%26quot%3B%20%26lt%3Bi%26gt%3BBundesgesundheitsblatt%2C%20Gesundheitsforschung%2C%20Gesundheitsschutz%26lt%3B%5C%2Fi%26gt%3B%2065%2C%20no.%209%20%282022%29%3A%20900%5Cu2013908.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-022-03563-6%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-022-03563-6%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Verordnungsverhalten%20von%20bayerischen%20Haus%5Cu00e4rzt%2Ainnen%20an%20der%20station%5Cu00e4r-ambulanten%20Schnittstelle%20vor%20dem%20Hintergrund%20der%20Bayerischen%20Wirkstoffvereinbarung%5Cu00a0%5Cu2013%20Qualitative%20Ergebnisse%20der%20WirtMed-Studie%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nikoletta%22%2C%22lastName%22%3A%22Zeschick%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Gollnick%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Muth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Franziska%22%2C%22lastName%22%3A%22H%5Cu00f6rbrand%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%22%2C%22lastName%22%3A%22Killian%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolfgang%22%2C%22lastName%22%3A%22Krombholz%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22K%5Cu00fchlein%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%22%2C%22lastName%22%3A%22Sebasti%5Cu00e3o%22%7D%5D%2C%22abstractNote%22%3A%22Hintergrund%20und%20Ziel%5CnZur%20transparenten%20Steuerung%20der%20Arzneimittelausgaben%20im%20Rahmen%20des%20Wirtschaftlichkeitsgebots%20%28%5Cu00a7%5Cu00a012%20F%5Cu00fcnftes%20Buch%20Sozialgesetzbuch%20%28SGB%5Cu00a0V%29%29%20hat%20die%20Kassen%5Cu00e4rztliche%20Vereinigung%20Bayerns%20im%20Jahr%202014%20die%20Wirkstoffvereinbarung%20%28WSV%29%20eingef%5Cu00fchrt.%20Diese%20hat%20die%20Richtgr%5Cu00f6%5Cu00dfensystematik%20abgel%5Cu00f6st.%20Mit%20Bezug%20auf%20die%20Rolle%20der%20WSV%20werden%20im%20Artikel%20die%20Gr%5Cu00fcnde%20der%20Haus%5Cu00e4rzt%2Ainnen%20%28H%5Cu00c4%29%20f%5Cu00fcr%20oder%20gegen%20eine%20Weiterverordnung%20von%20Arzneimitteln%20aus%20dem%20Krankenhaus%20beschrieben.%5Cn%5CnMaterial%20und%20Methode%5CnIn%20einem%20qualitativen%20Studiendesign%20wurden%20im%20Zeitraum%2011%5C%2F2019%20bis%2003%5C%2F2020%20mit%20bayerischen%20H%5Cu00c4%20Einzelinterviews%20%28n%5Cu202f%3D%5Cu200918%29%20und%202%5Cu00a0Fokusgruppen%20%28n%5Cu202f%3D%5Cu200910%29%20durchgef%5Cu00fchrt%20und%20nach%20der%20qualitativen%20Inhaltsanalyse%20ausgewertet.%5Cn%5CnErgebnisse%5CnMit%20der%20Einf%5Cu00fchrung%20der%20WSV%20nahmen%20die%20Regresssorgen%20der%20H%5Cu00c4%20insgesamt%20ab.%20Gro%5Cu00dfe%20Bedeutung%20bei%20Verordnungen%20haben%20%5Cu2013%5Cu00a0vor%20der%20Wirtschaftlichkeit%5Cu00a0%5Cu2013%20die%20patient%2Ainnenorientierte%20Versorgung%20und%20fachliche%20Richtigkeit%20von%20Therapieentscheidungen.%20Mit%20der%20Entlassmedikation%20ergeben%20sich%20wirtschaftliche%20Herausforderungen%2C%20besonders%20mit%20dem%20Leitsubstanzziel%20der%20oralen%20Antikoagulation%2C%20den%20Generikazielen%20bei%20Antidiabetika%20und%20bei%20Therapeutika%20f%5Cu00fcr%20das%20Herz-Kreislauf-System.%20Allgemein%20kritisiert%20werden%20Rabattvertr%5Cu00e4ge%2C%20die%20oft%20zu%20Umstellungen%20von%20Arzneimitteln%20f%5Cu00fchren.%20Vereinzelt%20wird%20von%20einer%20%5Cu201eVormachtstellung%5Cu201c%20der%20Klinik%5Cu00e4rzt%2Ainnen%20berichtet%2C%20die%20dem%20haus%5Cu00e4rztlichen%20wirtschaftlichen%20Handeln%20entgegenstehen.%20Es%20fehlt%20laut%20H%5Cu00c4%20eine%20sektoren%5Cu00fcbergreifende%20Kostenverantwortung.%5Cn%5CnDiskussion%5CnEin%20reibungsloser%20Schnittstellen%5Cu00fcbergang%20ist%20aus%20Sicht%20der%20H%5Cu00c4%20trotz%20des%20Rahmenvertrags%20Entlassmanagement%20und%20der%20neuen%20Steuerungssystematik%20der%20WSV%20im%20ambulanten%20Sektor%20noch%20nicht%20vorhanden.%20F%5Cu00fcr%20eine%20wirtschaftliche%20Arzneimittelversorgung%20bedarf%20es%20weiterhin%20einer%20sektoren%5Cu00fcbergreifenden%2C%20aber%20auch%20bundesl%5Cu00e4nder%5Cu00fcbergreifenden%20politischen%20Diskussion.%5Cn%5CnZusatzmaterial%20online%5CnIm%20Onlinematerial%20sind%20vertiefende%20Informationen%20zu%20der%20Methodik%20%28Onlinematerial%5Cu00a01%3A%20Interview-%20und%20Fokusgruppenleitfaden%29%20sowie%20zur%20Auswertung%20%28Onlinematerial%5Cu00a02%3A%20Kategoriensystem%29%20dieser%20Studie%20%2810.1007%5C%2Fs00103-022-03563-6%29%20verf%5Cu00fcgbar.%22%2C%22date%22%3A%222022%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00103-022-03563-6%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpmc%5C%2Farticles%5C%2FPMC9436878%5C%2F%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221436-9990%22%2C%22language%22%3A%22de%22%2C%22collections%22%3A%5B%22ZFT52UPQ%22%2C%2246NNKHWR%22%2C%22R2J5Y2I9%22%2C%22X7PUUBWP%22%2C%22SPWXRLZV%22%2C%22QXIGN3AI%22%2C%22BEQ38XPW%22%2C%22YT56KJXE%22%5D%2C%22dateModified%22%3A%222024-06-01T19%3A21%3A15Z%22%7D%7D%2C%7B%22key%22%3A%22KC89BTIJ%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Schulte%20et%20al.%22%2C%22parsedDate%22%3A%222021-09-30%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BSchulte%2C%20Erika%2C%20Claudia%20Spies%2C%20Claudia%20Denke%2C%20Joerg%20J.%20Meerpohl%2C%20Norbert%20Donner-Banzhoff%2C%20Frank%20Petzke%2C%20Ralph%20Hertwig%2C%20Michael%20Sch%26%23xE4%3Bfer%2C%20and%20Odette%20Wegwarth.%20%26%23x201C%3BPatients%26%23x2019%3B%20Self-Reported%20Physical%20and%20Psychological%20Effects%20of%20Opioid%20Use%20in%20Chronic%20Noncancer%20Pain-A%20Retrospective%20Cross-Sectional%20Analysis.%26%23x201D%3B%20%26lt%3Bi%26gt%3BEuropean%20Journal%20of%20Pain%20%28London%2C%20England%29%26lt%3B%5C%2Fi%26gt%3B%2C%20September%2030%2C%202021.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fejp.1868%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1002%5C%2Fejp.1868%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Patients%27%20self-reported%20physical%20and%20psychological%20effects%20of%20opioid%20use%20in%20chronic%20noncancer%20pain-A%20retrospective%20cross-sectional%20analysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erika%22%2C%22lastName%22%3A%22Schulte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Spies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Denke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joerg%20J.%22%2C%22lastName%22%3A%22Meerpohl%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Frank%22%2C%22lastName%22%3A%22Petzke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ralph%22%2C%22lastName%22%3A%22Hertwig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Michael%22%2C%22lastName%22%3A%22Sch%5Cu00e4fer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Odette%22%2C%22lastName%22%3A%22Wegwarth%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Strong%20opioids%20can%20have%20unintended%20effects.%20Clinical%20studies%20of%20strong%20opioids%20mainly%20report%20physical%20side%20effects%2C%20psychiatric%20or%20opioid%20use%20disorders.%20To%20date%2C%20too%20little%20attention%20has%20been%20paid%20to%20the%20psychological%20effects%20of%20opioids%20to%20treat%20patients%20with%20chronic%20noncancer%20pain%20%28CNCP%29.%20This%20study%20aims%20to%20identify%20and%20measure%20%28i%29%20the%20nature%20and%20frequency%20of%20physical%20and%20psychological%20effects%20and%20%28ii%29%20the%20degree%20of%20physician%20counseling%20of%20patients%20with%20CNCP%20taking%20strong%20opioids.%5CnMETHODS%3A%20Within%20a%20cross-sectional%20survey-conducted%20as%20part%20of%20a%20randomised%20controlled%20online%20intervention%20trial%20%28ERONA%20%5BExperiencing%20the%20risk%20of%20overusing%20opioids%20among%20patients%20with%20chronic%20non-cancer%20pain%20in%20ambulatory%20care%5D%29-300%20German%20CNCP%20patients%20were%20surveyed%20via%20patient-reported%20outcome%20measures%20regarding%20on%20both%20the%20side%20effects%20from%20their%20use%20of%20strong%20opioids%20as%20well%20as%20their%20counselling%20experience.%5CnRESULTS%3A%20Among%20the%20patients%26%23039%3B%20reported%20effects%2C%20the%20psychological%20outcomes%20of%20the%20opioids%20in%20CNCP%20were%3A%20feeling%20relaxed%20%2884%25%29%2C%20fatigue%20%2876%25%29%2C%20dizziness%20%2857%25%29%2C%20listlessness%20%2837%25%29%2C%20difficulty%20with%20mental%20activities%20%2823%25%29%2C%20dulled%20emotions%20%2817%25%29%20and%20poor%20memory%20%2817%25%29.%20Ninety-two%20per%20cent%20of%20the%20patients%20reported%20having%20received%20information%20about%20opioid%20effects%2C%20and%2046%25%20had%20discussed%20cessation%20of%20the%20opioid%20medication%20with%20their%20physicians%20before%20commencing%20the%20prescription.%5CnCONCLUSIONS%3A%20In%20addition%20to%20the%20well-known%20physical%20side%20effects%2C%20patients%20with%20CNCP%20taking%20strong%20opioids%20experience%20significant%20psychological%20effects.%20In%20view%20of%20these%20effects%2C%20discontinuation%20of%20opioid%20therapy%20should%20be%20discussed%20early%20to%20ensure%20their%20benefits%20do%20not%20outweigh%20their%20harm.%5CnSIGNIFICANCE%3A%20In%20this%20study%2C%20patients%20with%20non-cancer%20pain%20notice%20that%20opioids%20they%20have%20taken%20do%20not%20only%20cause%20physical%20side%20effects%20but%20also%20may%20have%20an%20impact%20on%20their%20psyche%20and%20their%20emotions%20and%2C%20thus%2C%20may%20also%20affect%20quality%20of%20life%20substantially.%20Clinical%20trial%20number%3A%20DRKS00020358.%22%2C%22date%22%3A%222021-09-30%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1002%5C%2Fejp.1868%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221532-2149%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22R2J5Y2I9%22%2C%22SPWXRLZV%22%2C%22QXIGN3AI%22%2C%22W637CI9M%22%2C%228B2HH96K%22%2C%22N24UXA6K%22%5D%2C%22dateModified%22%3A%222024-06-05T15%3A22%3A07Z%22%7D%7D%2C%7B%22key%22%3A%22BX9E7KCB%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Viniol%20et%20al.%22%2C%22parsedDate%22%3A%222021-09%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BViniol%2C%20Annika%2C%20J%26%23xF6%3Brg%20Haasenritter%2C%20Nina%20Grede%2C%20Karl%20Wegscheider%2C%20Annette%20Becker%2C%20Helmut%20Sitter%2C%20Ildik%26%23xF3%3B%20G%26%23xE1%3Bgyor%2C%20et%20al.%20%26%23x201C%3BTypology%20of%20Drug%20Discontinuation%20Trials%20-%20Methodological%20Recommendations.%26%23x201D%3B%20%26lt%3Bi%26gt%3BJournal%20of%20Clinical%20Epidemiology%26lt%3B%5C%2Fi%26gt%3B%20137%20%28September%202021%29%3A%2023%26%23x2013%3B30.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jclinepi.2021.03.017%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jclinepi.2021.03.017%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Typology%20of%20drug%20discontinuation%20trials%20-%20Methodological%20recommendations%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annika%22%2C%22lastName%22%3A%22Viniol%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00f6rg%22%2C%22lastName%22%3A%22Haasenritter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nina%22%2C%22lastName%22%3A%22Grede%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Karl%22%2C%22lastName%22%3A%22Wegscheider%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Becker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Helmut%22%2C%22lastName%22%3A%22Sitter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ildik%5Cu00f3%22%2C%22lastName%22%3A%22G%5Cu00e1gyor%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22S%5Cu00f6nnichsen%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Achim%22%2C%22lastName%22%3A%22Mortsiefer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ulrike%22%2C%22lastName%22%3A%22Junius-Walker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVE%3A%20Due%20to%20the%20increasing%20concerns%20about%20polypharmacy%2C%20there%20is%20a%20growing%20need%20for%20clinical%20recommendations%20for%20drug%20discontinuation.%20This%20requires%20studies%20investigating%20the%20process%20on%20several%20levels.%20This%20paper%20addresses%20the%20methodological%20problems%20of%20drug%20discontinuation%20trials%20%28DDTs%29.%20To%20that%20end%2C%20we%20offer%20a%20new%20typology%20of%20research%20aims%20and%20corresponding%20methodological%20recommendations%20for%20trials%20evaluating%20drug%20discontinuation.%5CnSTUDY%20DESIGN%20AND%20SETTING%3A%20Multi-stage%20development%20process%2C%20including%20literature%20search%20and%20expert%20panels.%5CnRESULTS%3A%20Clinical%20trials%20are%20only%20required%20in%20cases%20of%20scientific%20uncertainty.%20We%20identified%20three%20situations%20of%20uncertainty%20associated%20with%20drug%20discontinuation%20from%20which%20we%20derived%20three%20study%20types%3A%201%29%20Uncertainty%20regarding%20the%20effectiveness%20and%5C%2For%20safety%20of%20a%20drug%3B%202%29%20Uncertainty%20regarding%20the%20procedure%20of%20discontinuing%20a%20previously%20taken%20drug%3B%203%29%20Uncertainty%20regarding%20the%20effectiveness%20of%20complex%20strategies%20used%20to%20discontinue%20one%20or%20more%20drugs.%20We%20developed%20specific%20methodological%20recommendations%20for%20each%20study%20type.%5CnCONCLUSION%3A%20We%20offer%20a%20comprehensive%20definition%20of%20research%20aims%2C%20study%20designs%2C%20and%20methodological%20recommendations%20regarding%20DDTs.%20The%20typology%20we%20propose%20can%20help%20investigators%20clarify%20their%20research%20aims%20and%20study%20design.%20The%20type-specific%20methodological%20recommendation%20should%20improve%20the%20quality%20of%20future%20drug%20discontinuation%20trials.%22%2C%22date%22%3A%222021-09%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jclinepi.2021.03.017%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221878-5921%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22R2J5Y2I9%22%5D%2C%22dateModified%22%3A%222024-05-31T10%3A25%3A40Z%22%7D%7D%2C%7B%22key%22%3A%22MJNFV6KB%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Kuss%20et%20al.%22%2C%22parsedDate%22%3A%222021-08%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BKuss%2C%20Katrin%2C%20Charles%20Christian%20Adarkwah%2C%20Miriam%20Becker%2C%20Norbert%20Donner-Banzhoff%2C%20and%20Kathrin%20Schloessler.%20%26%23x201C%3BDelivering%20the%20Unexpected-Information%20Needs%20for%20PSA%20Screening%20from%20Men%26%23x2019%3Bs%20Perspective%3A%20A%20Qualitative%20Study.%26%23x201D%3B%20%26lt%3Bi%26gt%3BHealth%20Expectations%3A%20An%20International%20Journal%20of%20Public%20Participation%20in%20Health%20Care%20and%20Health%20Policy%26lt%3B%5C%2Fi%26gt%3B%2024%2C%20no.%204%20%28August%202021%29%3A%201403%26%23x2013%3B12.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fhex.13275%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fhex.13275%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Delivering%20the%20unexpected-Information%20needs%20for%20PSA%20screening%20from%20Men%27s%20perspective%3A%20A%20qualitative%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Katrin%22%2C%22lastName%22%3A%22Kuss%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charles%20Christian%22%2C%22lastName%22%3A%22Adarkwah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Miriam%22%2C%22lastName%22%3A%22Becker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22Schloessler%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Making%20decisions%20about%20PSA%20screening%20tests%20is%20challenging%2C%20as%20it%20requires%20both%20knowledge%20of%20the%20possible%20benefits%20and%20harms%20of%20screening%20and%20an%20individual%20assessment%20of%20the%20patient%26%23039%3Bs%20values.%20Our%20research%20explores%20how%20much%20and%20what%20information%20men%20perceive%20to%20be%20necessary%20with%20regard%20to%20screening%20for%20prostate%20cancer.%5CnOBJECTIVE%3A%20To%20explore%20men%26%23039%3Bs%20information%20and%20associated%20needs%20for%20decision%20making%20in%20PSA%20testing.%5CnDESIGN%3A%20Qualitative%20interview%20study.%5CnSETTING%20AND%20PARTICIPANTS%3A%20We%20interviewed%2032%20men%20%28aged%2055-69%29%20about%20their%20decision%20making%20on%20PSA%20screening%20following%20counselling%20with%20a%20Decision%20Aid%20at%20their%20GP%26%23039%3Bs%20or%20urologist%26%23039%3Bs%20practice%20in%20Germany.%5CnMAIN%20OUTCOME%20MEASURES%3A%20Men%26%23039%3Bs%20expressed%20needs%20for%20decision%20making%20in%20PSA%20testing.%5CnMETHODS%3A%20All%20interviews%20were%20transcribed%20verbatim%20and%20analysed%20by%20framework%20analysis.%5CnRESULTS%3A%20Comprehensive%20pre-screening%20counselling%20is%20needed.%20For%20the%20men%20in%20our%20study%2C%20information%20about%20test%20%28in%29accuracy%2C%20the%20benefit-harm%20balance%20and%20consequences%20of%20the%20test%20were%20relevant%20and%20surprising.%20Additional%20needs%20were%20for%20interpretation%20support%2C%20a%20take-home%20summary%20and%20time%20for%20deliberation.%20For%20several%20men%2C%20their%20physician%26%23039%3Bs%20attitude%20was%20of%20interest.%20After%20being%20well-informed%2C%20most%20men%20felt%20empowered%20to%20make%20a%20preference-based%20decision%20on%20their%20own.%5CnDISCUSSION%3A%20Men%20were%20surprised%20by%20what%20they%20learned%2C%20especially%20regarding%20the%20accuracy%20and%20possible%20harms%20of%20screening.%20There%20is%20large%20variation%20in%20the%20breadth%20and%20depth%20of%20information%20needed%2C%20and%20some%20controversy%20regarding%20the%20consequences%20of%20testing.%5CnCONCLUSION%20AND%20PATIENT%20CONTRIBUTION%3A%20A%20core%20set%20of%20information%20should%20be%20offered%20before%20men%20make%20their%20first%20PSA%20screening%20decision.%20Information%20about%20biopsy%20and%20associated%20side-effects%20could%20follow%20in%20a%20short%20form%2C%20with%20details%20only%20on%20request.%20Knowledge%20about%20a%20high%20rate%20of%20false-positive%20test%20results%20beforehand%20might%20help%20men%20handle%20a%20suspicious%20test%20result.%22%2C%22date%22%3A%222021-08%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1111%5C%2Fhex.13275%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221369-7625%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22ZFT52UPQ%22%2C%2246NNKHWR%22%2C%22R2J5Y2I9%22%2C%22X7PUUBWP%22%2C%22SPWXRLZV%22%2C%22QXIGN3AI%22%2C%22W637CI9M%22%2C%22JL4N5KDE%22%2C%22P9CVNWVH%22%2C%22AQHM6PNY%22%2C%22SXDM3NIR%22%5D%2C%22dateModified%22%3A%222024-05-26T15%3A06%3A25Z%22%7D%7D%2C%7B%22key%22%3A%2265JRMN8S%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Junius-Walker%20et%20al.%22%2C%22parsedDate%22%3A%222021-08%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BJunius-Walker%2C%20Ulrike%2C%20Annika%20Viniol%2C%20Matthias%20Michiels-Corsten%2C%20Navina%20Gerlach%2C%20Norbert%20Donner-Banzhoff%2C%20and%20Tanja%20Schleef.%20%26%23x201C%3BMediQuit%2C%20an%20Electronic%20Deprescribing%20Tool%20for%20Patients%20on%20Polypharmacy%3A%20Results%20of%20a%20Feasibility%20Study%20in%20German%20General%20Practice.%26%23x201D%3B%20%26lt%3Bi%26gt%3BDrugs%20%26amp%3B%20Aging%26lt%3B%5C%2Fi%26gt%3B%2038%2C%20no.%208%20%28August%202021%29%3A%20725%26%23x2013%3B33.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs40266-021-00861-7%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs40266-021-00861-7%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22MediQuit%2C%20an%20Electronic%20Deprescribing%20Tool%20for%20Patients%20on%20Polypharmacy%3A%20Results%20of%20a%20Feasibility%20Study%20in%20German%20General%20Practice%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ulrike%22%2C%22lastName%22%3A%22Junius-Walker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annika%22%2C%22lastName%22%3A%22Viniol%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Michiels-Corsten%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Navina%22%2C%22lastName%22%3A%22Gerlach%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tanja%22%2C%22lastName%22%3A%22Schleef%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Deprescribing%20is%20an%20important%20task%20for%20general%20practitioners%20%28GPs%29%20in%20the%20face%20of%20risky%20polypharmacy.%20The%20electronic%20tool%20%26quot%3BMediQuit%26quot%3B%20was%20developed%20to%20guide%20GPs%20and%20patients%20through%20a%20deprescribing%20consultation%20that%20entails%20a%20drug-selection%20phase%2C%20shared%20decision%20making%2C%20and%20advice%20on%20safe%20implementation.%5CnOBJECTIVES%3A%20A%20pilot%20study%20was%20conducted%20to%20determine%20the%20target%20group%20of%20patients%20that%20is%20selected%20for%20consultation%20and%20to%20assess%20the%20impact%2C%20patient%20involvement%2C%20and%20feasibility%20of%20the%20tool.%5CnMETHODS%3A%20This%20was%20an%20uncontrolled%20pilot%20study.%20GPs%20from%20two%20German%20regions%20were%20invited%20to%20use%20MediQuit%20in%20consultations%20with%20a%20view%20to%20deprescribing%20one%20drug%2C%20if%20appropriate.%20They%20selected%20patients%20on%20the%20basis%20of%20broad%20inclusion%20criteria.%20Collected%20data%20entailed%20participants%26%23039%3B%20characteristics%2C%20patients%26%23039%3B%20medication%20lists%2C%20deprescribed%20drugs%2C%20and%20feasibility%20assessments.%20Patients%20were%20contacted%20shortly%20after%20the%20consultation%20and%20again%20after%204%20weeks.%5CnRESULTS%3A%20In%20total%2C%2016%20GPs%20agreed%20to%20participate%2C%20of%20whom%20ten%20actually%20performed%20deprescribing%20consultations.%20They%20selected%2041%20predominately%20older%20patients%20on%20excessive%20polypharmacy.%20Deprescribing%20was%20achieved%20in%2070%25%20of%20consultations%20in%20agreement%20with%20patients.%20Drugs%20deprescribed%20were%20symptom-lowering%20and%20preventive%20drugs%20%28mainly%20anatomical%20therapeutic%20chemical%20classes%20A%20and%20C%29.%20GPs%20found%20MediQuit%20useful%20in%20initiating%20communication%20on%20this%20issue%20and%20enhancing%20deliberations%20for%20a%20deprescribing%20decision.%20The%20median%20consultation%20length%20was%2015%20min%20%28interquartile%20range%2010-20%29.%20At%20follow-up%2C%20GPs%20and%20patients%20infrequently%20disagreed%20on%20which%20drug%28s%29%20was%20discontinued%2C%20and%20GPs%20rated%20patient%20involvement%20higher%20than%20did%20patients%20themselves.%5CnDISCUSSION%3A%20MediQuit%20assists%20in%20identifying%20concrete%20deprescribing%20opportunities%2C%20patient%20involvement%2C%20and%20shared%20decision%20making.%20The%20three-step%20deprescribing%20procedure%20is%20well-accepted%20once%20initial%20organizational%20efforts%20are%20overcome.%20After%20revision%2C%20further%20studies%20are%20needed%20to%20enhance%20the%20quality%20of%20evidence%20on%20acceptance%20and%20effectiveness.%22%2C%22date%22%3A%222021-08%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1007%5C%2Fs40266-021-00861-7%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221179-1969%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%22ZFT52UPQ%22%2C%2246NNKHWR%22%2C%22R2J5Y2I9%22%5D%2C%22dateModified%22%3A%222024-03-11T09%3A25%3A18Z%22%7D%7D%2C%7B%22key%22%3A%2275T5ZXUU%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Maisel%20et%20al.%22%2C%22parsedDate%22%3A%222021-07-26%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMaisel%2C%20Peter%2C%20Erika%20Baum%2C%20and%20Norbert%20Donner-Banzhoff.%20%26%23x201C%3BFatigue%20as%20the%20Chief%20Complaint%20%26%23x2013%3B%20Epidemiology%2C%20Causes%2C%20Diagnosis%2C%20and%20Treatment.%26%23x201D%3B%20%26lt%3Bi%26gt%3BDeutsches%20Arzteblatt%20International%26lt%3B%5C%2Fi%26gt%3B%2C%20no.%20Forthcoming%20%28July%2026%2C%202021%29%3A%20arztebl.m2021.0192.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3238%5C%2Farztebl.m2021.0192%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3238%5C%2Farztebl.m2021.0192%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Fatigue%20as%20the%20Chief%20Complaint%20%5Cu2013%20Epidemiology%2C%20Causes%2C%20Diagnosis%2C%20and%20Treatment%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%22%2C%22lastName%22%3A%22Maisel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erika%22%2C%22lastName%22%3A%22Baum%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Fatigue%20is%20a%20main%20or%20secondary%20reason%20for%2010-20%25%20of%20all%20consultations%20with%20a%20primary%20care%20physician.%5CnMETHODS%3A%20This%20review%20is%20based%20on%20pertinent%20publications%20retrieved%20by%20a%20comprehensive%2C%20selective%20literature%20search%20on%20the%20epidemiology%2C%20etiology%2C%20and%20diagnostic%20evaluation%20of%20fatigue%20as%20a%20leading%20symptom%20of%20disease%2C%20as%20well%20as%20on%20the%20treatment%20of%20its%20common%20causes.%20Information%20was%20also%20included%20from%20the%20literature%20search%20we%20conducted%20for%20the%20German%20clinical%20practice%20guideline%20on%20fatigue%20that%20was%20issued%20by%20the%20German%20College%20of%20General%20Practitioners%20and%20Family%20Physicians%20%28Deutsche%20Gesellschaft%20f%5Cu00fcr%20Allgemeinmedizin%20und%20Familienmedizin%2C%20DEGAM%29.%5CnRESULTS%3A%20Fatigue%20can%20be%20due%20to%20any%20of%20a%20broad%20spectrum%20of%20diseases%2C%20including%20decompensation%20of%20already%20known%20conditions.%20Sleep%20disorders%20and%20sleep-related%20disorders%20of%20breathing%2C%20depression%20%2818.5%25%29%2C%20and%20excessive%20psychosocial%20stress%20are%20the%20most%20common%20causes%20of%20persistent%20fatigue.%20Previously%20undiagnosed%20cancer%20is%20a%20rare%20cause%2C%20accounting%20for%20only%200.6%25%20of%20cases%20%2895%25%20confidence%20interval%20%5B0.3%3B%201.3%5D%29.%20Anemia%20and%20other%20organic%20causes%20are%20rare%20as%20well%20%284.3%25%20%5B2.7%3B%206.7%5D%29.%20Investigations%20beyond%20the%20history%2C%20physical%20examination%2C%20and%20simple%20laboratory%20tests%20are%20needed%20only%20in%20the%20presence%20of%20additional%20symptoms%20or%20findings.%20If%20the%20diagnosis%20remains%20unclear%2C%20watchful%20waiting%20and%20regularly%20scheduled%20follow-up%20help%20prevent%20an%20excessive%20focus%20on%20somatic%20causes%2C%20leading%20to%20overdiagnosis.%20Irrespective%20of%20specific%20causes%2C%20psychoeducative%20and%20psychotherapeutic%20approaches%20should%20be%20discussed%20with%20the%20patient%2C%20as%20well%20as%20an%20individually%20adapted%20exercise%20program.%5CnCONCLUSION%3A%20The%20work-up%20of%20fatigue%20as%20a%20chief%20complaint%20should%20be%20guided%20by%20investigating%20common%20and%5C%2For%20potentially%20dangerous%20disorders.%20Since%20the%20latter%20are%20rare%2C%20an%20exclusively%20somatic%20focus%20should%20be%20avoided%20in%20order%20to%20prevent%20overdiagnosis.%22%2C%22date%22%3A%222021-07-26%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.3238%5C%2Farztebl.m2021.0192%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221866-0452%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22R2J5Y2I9%22%2C%22SPWXRLZV%22%2C%22QXIGN3AI%22%2C%22W637CI9M%22%5D%2C%22dateModified%22%3A%222025-05-18T07%3A56%3A09Z%22%7D%7D%2C%7B%22key%22%3A%2243AWANLL%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bergmann%20et%20al.%22%2C%22parsedDate%22%3A%222021-07-12%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BBergmann%2C%20Milena%2C%20J%26%23xF6%3Brg%20Haasenritter%2C%20Dominik%20Beidatsch%2C%20Sonja%20Schwarm%2C%20Kaja%20H%26%23xF6%3Brner%2C%20Stefan%20B%26%23xF6%3Bsner%2C%20Paula%20Grevenrath%2C%20et%20al.%20%26%23x201C%3BPrevalence%2C%20Aetiologies%20and%20Prognosis%20of%20the%20Symptom%20Cough%20in%20Primary%20Care%3A%20A%20Systematic%20Review%20and%20Meta-Analysis.%26%23x201D%3B%20%26lt%3Bi%26gt%3BBMC%20Family%20Practice%26lt%3B%5C%2Fi%26gt%3B%2022%2C%20no.%201%20%28July%2012%2C%202021%29%3A%20151.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12875-021-01501-0%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12875-021-01501-0%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Prevalence%2C%20aetiologies%20and%20prognosis%20of%20the%20symptom%20cough%20in%20primary%20care%3A%20a%20systematic%20review%20and%20meta-analysis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Milena%22%2C%22lastName%22%3A%22Bergmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00f6rg%22%2C%22lastName%22%3A%22Haasenritter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominik%22%2C%22lastName%22%3A%22Beidatsch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sonja%22%2C%22lastName%22%3A%22Schwarm%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kaja%22%2C%22lastName%22%3A%22H%5Cu00f6rner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22B%5Cu00f6sner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paula%22%2C%22lastName%22%3A%22Grevenrath%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annika%22%2C%22lastName%22%3A%22Viniol%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Becker%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Cough%20is%20a%20relevant%20reason%20for%20encounter%20in%20primary%20care.%20For%20evidence-based%20decision%20making%2C%20general%20practitioners%20need%20setting-specific%20knowledge%20about%20prevalences%2C%20pre-test%20probabilities%2C%20and%20prognosis.%20Accordingly%2C%20we%20performed%20a%20systematic%20review%20of%20symptom-evaluating%20studies%20evaluating%20cough%20as%20reason%20for%20encounter%20in%20primary%20care.%5CnMETHODS%3A%20We%20conducted%20a%20search%20in%20MEDLINE%20and%20EMBASE.%20Eligibility%20criteria%20and%20methodological%20quality%20were%20assessed%20independently%20by%20two%20reviewers.%20We%20extracted%20data%20on%20prevalence%2C%20aetiologies%20and%20prognosis%2C%20and%20estimated%20the%20variation%20across%20studies.%20If%20justifiable%20in%20terms%20of%20heterogeneity%2C%20we%20performed%20a%20meta-analysis.%5CnRESULTS%3A%20We%20identified%2021%20eligible%20studies%20on%20prevalence%2C%2012%20on%20aetiology%2C%20and%20four%20on%20prognosis.%20Prevalence%5C%2Fincidence%20estimates%20were%203.8-4.2%25%5C%2F12.5%25%20%28Western%20primary%20care%29%20and%2010.3-13.8%25%5C%2F6.3-6.5%25%20in%20Africa%2C%20Asia%20and%20South%20America.%20In%20Western%20countries%20the%20underlying%20diagnoses%20for%20acute%20cough%20or%20cough%20of%20all%20durations%20were%20respiratory%20tract%20infections%20%2873-91.9%25%29%2C%20influenza%20%286-15.2%25%29%2C%20asthma%20%283.2-15%25%29%2C%20laryngitis%5C%2Ftracheitis%20%283.6-9%25%29%2C%20pneumonia%20%284.0-4.2%25%29%2C%20COPD%20%280.5-3.3%25%29%2C%20heart%20failure%20%280.3%25%29%2C%20and%20suspected%20malignancy%20%280.2-1.8%25%29.%20Median%20time%20for%20recovery%20was%209%20to%2011%5Cu00a0days.%20Complete%20recovery%20was%20reported%20by%2040.2-%2067%25%20of%20patients%20after%20two%20weeks%2C%20and%20by%2079%25%20after%20four%20weeks.%20About%2021.1-35%25%20of%20patients%20re-consulted%3B%200-1.3%25%20of%20acute%20cough%20patients%20were%20hospitalized%2C%20none%20died.%20Evidence%20is%20missing%20concerning%20subacute%20and%20chronic%20cough.%5CnCONCLUSION%3A%20Prevalences%20and%20incidences%20of%20cough%20are%20high%20and%20show%20regional%20variation.%20Acute%20cough%2C%20mainly%20caused%20by%20respiratory%20tract%20infections%2C%20is%20usually%20self-limiting%20%28supporting%20a%20%26quot%3Bwait-and-see%26quot%3B%20strategy%29.%20We%20have%20no%20setting-specific%20evidence%20to%20support%20current%20guideline%20recommendations%20concerning%20subacute%20or%20chronic%20cough%20in%20Western%20primary%20care.%20Our%20study%20presents%20epidemiological%20data%20under%20non%20non-pandemic%20conditions.%20It%20will%20be%20interesting%20to%20compare%20these%20data%20to%20future%20research%20results%20of%20the%20post-pandemic%20era.%22%2C%22date%22%3A%222021-07-12%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12875-021-01501-0%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221471-2296%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%226DTIS6M4%22%2C%22R2J5Y2I9%22%2C%22X7PUUBWP%22%2C%22SPWXRLZV%22%2C%228B2HH96K%22%2C%22ACPQBWRE%22%5D%2C%22dateModified%22%3A%222025-05-18T07%3A56%3A27Z%22%7D%7D%2C%7B%22key%22%3A%22PB6BZ4L2%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Wehkamp%20et%20al.%22%2C%22parsedDate%22%3A%222021-06-14%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BWehkamp%2C%20Kai%2C%20Felicia%20Beatrice%20Kiefer%2C%20Friedemann%20Geiger%2C%20Fueloep%20Scheibler%2C%20Jens%20Ulrich%20Rueffer%2C%20Norbert%20Donner-Banzhoff%2C%20and%20Cornelia%20Betsch.%20%26quot%3B%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.dovepress.com%5C%2Fenhancing-specific-health-literacy-with-a-digital-evidence-based-patie-peer-reviewed-fulltext-article-PPA%26%23039%3B%26gt%3BEnhancing%20Specific%20Health%20Literacy%20with%20a%20Digital%20Evidence-Based%20Patient%20Decision%20Aid%20for%20Hypertension%3A%20A%20Randomized%20Controlled%20Trial.%26lt%3B%5C%2Fa%26gt%3B%26quot%3B%20%26lt%3Bi%26gt%3BPatient%20Preference%20and%20Adherence%26lt%3B%5C%2Fi%26gt%3B%2015%20%28June%2014%2C%202021%29%3A%201269%5Cu201379.%20https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.2147%5C%2FPPA.S311470.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Enhancing%20Specific%20Health%20Literacy%20with%20a%20Digital%20Evidence-Based%20Patient%20Decision%20Aid%20for%20Hypertension%3A%20A%20Randomized%20Controlled%20Trial.%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kai%22%2C%22lastName%22%3A%22Wehkamp%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Felicia%20Beatrice%22%2C%22lastName%22%3A%22Kiefer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Friedemann%22%2C%22lastName%22%3A%22Geiger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fueloep%22%2C%22lastName%22%3A%22Scheibler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jens%20Ulrich%22%2C%22lastName%22%3A%22Rueffer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cornelia%22%2C%22lastName%22%3A%22Betsch%22%7D%5D%2C%22abstractNote%22%3A%22Enhancing%20Specific%20Health%20Literacy%20with%20a%20Digital%20Evidence-Based%20Patient%20Decision%20Aid%20for%20Hypertension%20%5Cu2013%20a%20Randomized%20Controlled%20Trial%22%2C%22date%22%3A%222021%5C%2F06%5C%2F14%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.2147%5C%2FPPA.S311470%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.dovepress.com%5C%2Fenhancing-specific-health-literacy-with-a-digital-evidence-based-patie-peer-reviewed-fulltext-article-PPA%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22language%22%3A%22English%22%2C%22collections%22%3A%5B%22ZFT52UPQ%22%2C%2246NNKHWR%22%2C%222G8YLGV7%22%2C%223L4EXKAR%22%2C%22R2J5Y2I9%22%2C%22J987ELTY%22%2C%227C3HQD4E%22%2C%22ERQ322N6%22%5D%2C%22dateModified%22%3A%222024-03-11T11%3A58%3A05Z%22%7D%7D%2C%7B%22key%22%3A%22J4WJUYD8%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Bergmann%20et%20al.%22%2C%22parsedDate%22%3A%222021-06-04%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BBergmann%2C%20Milena%2C%20J%26%23xF6%3Brg%20Haasenritter%2C%20Dominik%20Beidatsch%2C%20Sonja%20Schwarm%2C%20Kaja%20H%26%23xF6%3Brner%2C%20Stefan%20B%26%23xF6%3Bsner%2C%20Paula%20Grevenrath%2C%20et%20al.%20%26%23x201C%3BCoughing%20Children%20in%20Family%20Practice%20and%20Primary%20Care%3A%20A%20Systematic%20Review%20of%20Prevalence%2C%20Aetiology%20and%20Prognosis.%26%23x201D%3B%20%26lt%3Bi%26gt%3BBMC%20Pediatrics%26lt%3B%5C%2Fi%26gt%3B%2021%2C%20no.%201%20%28June%204%2C%202021%29%3A%20260.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12887-021-02739-4%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12887-021-02739-4%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Coughing%20children%20in%20family%20practice%20and%20primary%20care%3A%20a%20systematic%20review%20of%20prevalence%2C%20aetiology%20and%20prognosis%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Milena%22%2C%22lastName%22%3A%22Bergmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00f6rg%22%2C%22lastName%22%3A%22Haasenritter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dominik%22%2C%22lastName%22%3A%22Beidatsch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sonja%22%2C%22lastName%22%3A%22Schwarm%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kaja%22%2C%22lastName%22%3A%22H%5Cu00f6rner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22B%5Cu00f6sner%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paula%22%2C%22lastName%22%3A%22Grevenrath%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Laura%22%2C%22lastName%22%3A%22Schmidt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annika%22%2C%22lastName%22%3A%22Viniol%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annette%22%2C%22lastName%22%3A%22Becker%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20For%20evidence-based%20decision%20making%2C%20primary%20care%20physicians%20need%20to%20have%20specific%20and%20reliable%20information%20on%20the%20pre-test%20probabilities%20of%20underlying%20diseases%20and%20a%20symptom%26%23039%3Bs%20course.%20We%20performed%20a%20systematic%20review%20of%20symptom-evaluating%20studies%20in%20primary%20care%2C%20following%20three%20research%20questions%3A%20%281%29%20What%20is%20the%20prevalence%20of%20the%20symptom%20cough%20in%20children%20consulting%20primary%20care%20physicians%3F%20%282%29%20What%20are%20the%20underlying%20aetiologies%20of%20cough%20and%20the%20respective%20frequencies%3F%20%283%29%20What%20is%20the%20prognosis%20of%20children%20with%20cough%3F%5CnMETHODS%3A%20Following%20a%20pre-defined%20algorithm%20and%20independent%20double%20reviewer%20ratings%20we%20searched%20MEDLINE%20and%20EMBASE.%20All%20quantitative%20original%20research%20articles%20in%20English%2C%20French%20or%20German%20were%20included%20if%20they%20focused%20on%20unselected%20study%20populations%20of%20children%20consulting%20a%20primary%20care%20physician%20for%20cough.%20We%20used%20the%20random%20effects%20model%20for%20meta-analysis%20in%20subgroups%2C%20if%20justifiable%20in%20terms%20of%20heterogeneity.%5CnRESULTS%3A%20We%20identified%2014%20eligible%20studies%20on%20prevalence%2C%20five%20on%20aetiology%20and%20one%20on%20prognosis.%20Prevalence%20estimates%20varied%20between%204.7%20and%2023.3%25%20of%20all%20reasons%20for%20an%20encounter%2C%20or%20up%20to%20estimates%20of%2060%25%20when%20related%20to%20patients%20or%20consultations.%20Cough%20in%20children%20is%20more%20frequent%20than%20in%20adults%2C%20with%20lowest%20prevalences%20in%20adolescents%20and%20in%20summer.%20Acute%20cough%20is%20mostly%20caused%20by%20upper%20respiratory%20tract%20infections%20%2862.4%25%29%20and%20bronchitis%20%2833.3%25%29%3B%20subacute%20or%20chronic%20cough%20by%20recurrent%20respiratory%20tract%20infection%20%2827.7%25%29%2C%20asthma%20%28up%20to%2050.4%25%20in%20cough%20persisting%20more%20than%203%5Cu2009weeks%29%2C%20and%20pertussis%20%2837.2%25%29.%20Potentially%20serious%20diseases%20like%20croup%2C%20pneumonia%20or%20tuberculosis%20are%20scarce.%20In%20children%20with%20subacute%20and%20chronic%20cough%20the%20total%20duration%20of%20cough%20ranged%20from%2024%20to%20192%5Cu2009days.%20About%2062.3%25%20of%20children%20suffering%20from%20prolonged%20cough%20are%20still%20coughing%20two%20months%20after%20the%20beginning%20of%20symptoms.%5CnCONCLUSION%3A%20Cough%20is%20one%20of%20the%20most%20frequent%20reasons%20for%20an%20encounter%20in%20primary%20care.%20Our%20findings%20fit%20in%20with%20current%20guideline%20recommendations%20supporting%20a%20thoughtful%20wait-and-see%20approach%20in%20acute%20cough%20and%20a%20special%20awareness%20in%20chronic%20cough%20of%20the%20possibility%20of%20asthma%20and%20pertussis.%20Further%20evidence%20of%20aetiological%20pre-test%20probabilities%20is%20needed%20to%20assess%20the%20diagnostic%20gain%20based%20on%20patient%20history%20and%20clinical%20signs%20for%20differential%20diagnoses%20of%20cough%20in%20children.%22%2C%22date%22%3A%222021-06-04%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12887-021-02739-4%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221471-2431%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%226DTIS6M4%22%2C%22S488ZYK4%22%2C%22R2J5Y2I9%22%2C%22X7PUUBWP%22%2C%22SPWXRLZV%22%2C%228B2HH96K%22%2C%22YT56KJXE%22%2C%22ACPQBWRE%22%5D%2C%22dateModified%22%3A%222025-05-18T07%3A55%3A50Z%22%7D%7D%2C%7B%22key%22%3A%22A99BIJAK%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Blumenthal%20et%20al.%22%2C%22parsedDate%22%3A%222021-02-02%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BBlumenthal%2C%20Sandra%2C%20Norbert%20Donner-Banzhoff%2C%20Uwe%20Popert%2C%20and%20Thomas%20K%5Cu00fchlein.%20%26quot%3B%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Flink.springer.com%5C%2Farticle%5C%2F10.3238%5C%2Fzfa.2021.0066-0071%26%23039%3B%26gt%3BZwischen%20Heilkunst%20und%20Kommerz%3A%20Welche%20%5Cu00d6konomie%20vertr%5Cu00e4gt%20%26quot%3Bgute%26quot%3B%20Medizin%3F%20-%20Online%20ZFA%26lt%3B%5C%2Fa%26gt%3B.%26quot%3B%20%26lt%3Bi%26gt%3B02%26lt%3B%5C%2Fi%26gt%3B%2002%2C%20no.%20966%20%28February%202%2C%202021%29%3A%2066%5Cu201366.%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Zwischen%20Heilkunst%20und%20Kommerz%3A%20Welche%20%5Cu00d6konomie%20vertr%5Cu00e4gt%20%5C%22gute%5C%22%20Medizin%3F%20-%20Online%20ZFA%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sandra%22%2C%22lastName%22%3A%22Blumenthal%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Uwe%22%2C%22lastName%22%3A%22Popert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%22%2C%22lastName%22%3A%22K%5Cu00fchlein%22%7D%5D%2C%22abstractNote%22%3A%221%20Hausarztpraxis%20in%20Potsdam-Babelsberg2%20Abteilung%20f%5Cu00fcr%20Allgemeinmedizin%2C%20Pr%5Cu00e4ventive%20und%20Rehabilitative%20Medizin%2C%20Philipps-Universit%5Cu00e4t%20Marburg3...%22%2C%22date%22%3A%222021%5C%2F02%5C%2F02%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%22%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Flink.springer.com%5C%2Farticle%5C%2F10.3238%5C%2Fzfa.2021.0066-0071%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%22%22%2C%22language%22%3A%22de%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22R2J5Y2I9%22%2C%22SPWXRLZV%22%2C%22QXIGN3AI%22%2C%22YT56KJXE%22%5D%2C%22dateModified%22%3A%222024-06-01T13%3A32%3A43Z%22%7D%7D%2C%7B%22key%22%3A%223HT829MG%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Grede%20et%20al.%22%2C%22parsedDate%22%3A%222021-01-13%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGrede%2C%20Nina%2C%20Anja%20Rieckert%2C%20Julia%20Muth%2C%20Joana%20Steinbuck%2C%20Sabine%20Weissbach%2C%20Annika%20Schneider%2C%20Beate%20Weber-Schicker%2C%20et%20al.%20%26%23x201C%3BA%20Volunteer-Supported%20Walking%20Programme%20to%20Improve%20Physical%20Function%20in%20Older%20People%20%28the%20POWER%20Study%29%3A%20Study%20Protocol%20for%20a%20Randomised%20Controlled%20Trial.%26%23x201D%3B%20%26lt%3Bi%26gt%3BBMC%20Geriatrics%26lt%3B%5C%2Fi%26gt%3B%2021%2C%20no.%201%20%28January%2013%2C%202021%29%3A%2045.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12877-020-01988-9%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12877-020-01988-9%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22A%20volunteer-supported%20walking%20programme%20to%20improve%20physical%20function%20in%20older%20people%20%28the%20POWER%20Study%29%3A%20study%20protocol%20for%20a%20randomised%20controlled%20trial%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nina%22%2C%22lastName%22%3A%22Grede%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Anja%22%2C%22lastName%22%3A%22Rieckert%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Muth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joana%22%2C%22lastName%22%3A%22Steinbuck%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sabine%22%2C%22lastName%22%3A%22Weissbach%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annika%22%2C%22lastName%22%3A%22Schneider%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beate%22%2C%22lastName%22%3A%22Weber-Schicker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ellen%22%2C%22lastName%22%3A%22Freiberger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Nikita%22%2C%22lastName%22%3A%22Jegan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%22%2C%22lastName%22%3A%22S%5Cu00f6nnichsen%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20Currently%2021%25%20of%20the%20German%20population%20is%20older%20than%2065%5Cu2009years.%20Above%20this%20age%2C%20the%20risk%20of%20suffering%20from%20chronic%20disease%20and%20mental%20disorders%20increases%20rapidly.%20Therefore%2C%20physical%20inactivity%20is%20one%20of%20the%20most%20important%20public%20health%20concerns%20among%20older%20people.%20To%20address%20this%20issue%2C%20we%20have%20conceptualised%20and%20evaluated%20a%20simple%20and%20low-threshold%20intervention%2C%20which%20requires%20only%20minimal%20demand%20on%20the%20participants%2C%20targeting%20older%20people%20with%20inadequate%20activity%20levels.%20The%20aim%20of%20the%20POWER%20Study%20is%20to%20investigate%20whether%20volunteer-supported%20outdoor-walking%20improves%20physical%20function%20and%20quality%20of%20life%20in%20older%20people.%5CnMETHODS%5C%2FDESIGN%3A%20In%20a%20randomised%2C%20controlled%20interventional%20superiority-trial%2C%20individuals%20older%20than%2065%5Cu2009years%20of%20age%20living%20in%20the%20community%20or%20nursing%20homes%20will%20be%20randomised%20into%20two%20groups.%20The%20study%20will%20be%20conducted%20in%20two%20study%20centres%20with%20assessments%20at%20baseline%2C%206%20and%2012%5Cu2009months.%20The%20intervention%20group%20will%20participate%20in%20a%20supported%20physical%20activity%20intervention%20for%206%5Cu2009months.%20An%20assigned%20volunteer%20will%20visit%20them%20three%20times%20a%20week%20for%20an%20outdoor%20walk%20between%2030%20and%2050%5Cu2009min%2C%20or%20equivalent%20indoor%20activity.%20Persons%20in%20the%20control%20group%20will%20be%20invited%20to%20two%20lectures%20covering%20topics%20related%20to%20health.%20Primary%20endpoint%20is%20the%20physical%20function%20measured%20by%20the%20Short%20Physical%20Performance%20Battery%20%28SPPB%29%20at%20baseline%2C%20after%206%20and%2012%5Cu2009months.%20Secondary%20and%20safety%20endpoints%20will%20be%20quality%20of%20life%20%28EQ.%205D%29%2C%20fear%20of%20falling%20%28Falls%20Efficacy%20Scale%29%2C%20physical%20activity%20%28activity%20diary%29%2C%20cognitive%20executive%20function%20%28clock%20drawing%20test%29%2C%20falls%20requiring%20medical%20attention%2C%20hospitalisation%20and%20death.%20Primary%20analysis%20will%20be%20carried%20out%20by%20intention%20to%20treat.%5CnDISCUSSION%3A%20We%20expect%20the%20intervention%20to%20improve%20the%20overall%20health%20status%20of%20the%20participants%20in%20a%20wide%20range%20of%20health-related%20outcomes.%20If%20effectiveness%20can%20be%20shown%2C%20the%20intervention%20will%20close%20an%20important%20gap%20in%20current%20services%20for%20older%20people.%20We%20will%20disseminate%20our%20experiences%20and%20results%20in%20the%20form%20of%20informational%20documents%20%28training%20manual%29%20to%20allow%20municipalities%20and%20health%20care%20organisations%20to%20implement%20a%20similar%20intervention.%5CnTRIAL%20REGISTRATION%3A%20The%20trial%20was%20registered%20on%2031%20Aug%202018%3B%20German%20Clinical%20Trials%20Register%20%28www.germanctr.de%29%2C%20Deutsches%20Register%20Klinischer%20Studien%3A%20DRKS00015188%20.%22%2C%22date%22%3A%222021-01-13%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12877-020-01988-9%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221471-2318%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22R2J5Y2I9%22%2C%22SPWXRLZV%22%2C%22822NCPZM%22%2C%222JLBQKWD%22%2C%22BEQ38XPW%22%2C%22N24UXA6K%22%5D%2C%22dateModified%22%3A%222024-06-06T02%3A39%3A16Z%22%7D%7D%2C%7B%22key%22%3A%22D8RYR24C%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Frank-Tewaag%20et%20al.%22%2C%22parsedDate%22%3A%222020-12-13%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BFrank-Tewaag%2C%20Julia%2C%20Julian%20Bleek%2C%20Dirk%20Horenkamp-Sonntag%2C%20Ursula%20Marschall%2C%20Uwe%20Zeymer%2C%20Norbert%20Donner-Banzhoff%2C%20and%20Leonie%20Sundmacher.%20%26%23x201C%3BUse%20of%20Guideline-Recommended%20Drug%20Therapy%20in%20Patients%20Undergoing%20Percutaneous%20Coronary%20Intervention%20for%20Stable%20Coronary%20Heart%20Disease%20in%20Germany%3A%20A%20Multilevel%20Analysis%20of%20Nationwide%20Routine%20Data.%26%23x201D%3B%20%26lt%3Bi%26gt%3BBMJ%20Open%26lt%3B%5C%2Fi%26gt%3B%2010%2C%20no.%2012%20%28December%2013%2C%202020%29%3A%20e042886.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjopen-2020-042886%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjopen-2020-042886%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Use%20of%20guideline-recommended%20drug%20therapy%20in%20patients%20undergoing%20percutaneous%20coronary%20intervention%20for%20stable%20coronary%20heart%20disease%20in%20Germany%3A%20a%20multilevel%20analysis%20of%20nationwide%20routine%20data%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julia%22%2C%22lastName%22%3A%22Frank-Tewaag%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Julian%22%2C%22lastName%22%3A%22Bleek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dirk%22%2C%22lastName%22%3A%22Horenkamp-Sonntag%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ursula%22%2C%22lastName%22%3A%22Marschall%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Uwe%22%2C%22lastName%22%3A%22Zeymer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Leonie%22%2C%22lastName%22%3A%22Sundmacher%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVES%3A%20To%20determine%20the%20prescription%20of%20guideline%20recommended%20drug%20therapy%20in%20patients%20with%20stable%20coronary%20heart%20disease%20%28sCHD%29%20prior%20to%20percutaneous%20coronary%20intervention%20%28PCI%29%20in%20Germany%20and%20to%20examine%20the%20role%20of%20patient%20characteristics%20and%20features%20of%20regional%20healthcare%20supply%20in%20a%20multilevel%20model.%5CnDESIGN%3A%20Secondary%20data%20analysis%20of%20factors%20associated%20with%20the%20prescription%20of%20guideline%20recommended%20drug%20therapy%20using%20a%20multilevel%20model%20to%20analyse%20regional-level%20effects%2C%20over%20and%20above%20the%20effects%20of%20patient-level%20demographic%20and%20health%20status.%5CnSETTING%3A%20Office-based%20prescriptions%20in%20the%20year%20prior%20to%20the%20invasive%20procedure.%5CnPARTICIPANTS%3A%20A%20linked%20nationwide%20dataset%20from%20Germany%26%23039%3Bs%20three%20largest%20statutory%20health%20insurance%20funds%20of%20all%20patients%20receiving%20PCI%20in%20the%20year%202016.%5CnMAIN%20OUTCOME%20MEASURES%3A%20Patients%26%23039%3B%20odds%20of%20receiving%20optimal%20medical%20therapy%20and%20symptom-oriented%20therapy%20within%201%5Cu2009year%20prior%20to%20PCI.%5CnRESULTS%3A%2068.6%25%20of%20patients%20received%20at%20least%20one%20lipid-lowering%20drug%20and%20one%20symptom-oriented%20therapy%20prior%20to%20PCI.%2043.6%25%20received%20at%20least%20two%20agents%20to%20control%20their%20symptoms.%20Patients%20who%20received%20treatment%20in%20accordance%20with%20the%20recommendations%20had%20a%20greater%20number%20of%20diagnosed%20risk%20factors%2C%20a%20more%20severe%20history%20of%20cardiac%20disease%20and%20used%20a%20higher%20volume%20of%20ambulatory%20office-based%20physician%20services.%20The%20prescriptions%20prevalence%20for%20the%20symptom-oriented%20therapies%20differed%20significantly%20between%20eastern%20and%20western%20Germany%2C%20with%20a%20higher%20prevalence%20in%20the%20eastern%20districts.%5CnCONCLUSIONS%3A%20Guidelines%20can%20only%20provide%20decision-making%20corridors%2C%20and%20the%20applicability%20of%20recommendations%20must%20always%20be%20assessed%20on%20a%20case%20by%20case%20basis.%20Nevertheless%2C%20our%20analysis%20indicates%20that%20the%20prevalence%20of%20prescriptions%20in%20routine%20practice%20is%20subject%20to%20substantial%20variation%20and%20that%20conservative%20therapy%20options%20are%20not%20fully%20exhausted%20prior%20to%20PCI.%20This%20suggests%20that%20there%20might%20be%20room%20for%20improvement%20in%20the%20care%20of%20patients%20with%20sCHD.%22%2C%22date%22%3A%222020-12-13%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1136%5C%2Fbmjopen-2020-042886%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222044-6055%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22R2J5Y2I9%22%2C%22SPWXRLZV%22%2C%22QXIGN3AI%22%2C%224KVK6YUS%22%2C%22P9CVNWVH%22%5D%2C%22dateModified%22%3A%222024-03-11T09%3A24%3A37Z%22%7D%7D%2C%7B%22key%22%3A%22KCAE65FW%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Wegwarth%20et%20al.%22%2C%22parsedDate%22%3A%222020-09-06%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BWegwarth%2C%20Odette%2C%20Claudia%20Spies%2C%20Erika%20Schulte%2C%20Joerg%20J.%20Meerpohl%2C%20Christine%20Schmucker%2C%20Edris%20Nury%2C%20Dirk%20Brockmann%2C%20et%20al.%20%26%23x201C%3BExperiencing%20the%20Risk%20of%20Overutilising%20Opioids%20among%20Patients%20with%20Chronic%20Non-Cancer%20Pain%20in%20Ambulatory%20Care%20%28ERONA%29%3A%20The%20Protocol%20of%20an%20Exploratory%2C%20Randomised%20Controlled%20Trial.%26%23x201D%3B%20%26lt%3Bi%26gt%3BBMJ%20Open%26lt%3B%5C%2Fi%26gt%3B%2010%2C%20no.%209%20%28September%206%2C%202020%29%3A%20e037642.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjopen-2020-037642%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1136%5C%2Fbmjopen-2020-037642%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Experiencing%20the%20risk%20of%20overutilising%20opioids%20among%20patients%20with%20chronic%20non-cancer%20pain%20in%20ambulatory%20care%20%28ERONA%29%3A%20the%20protocol%20of%20an%20exploratory%2C%20randomised%20controlled%20trial%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Odette%22%2C%22lastName%22%3A%22Wegwarth%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Claudia%22%2C%22lastName%22%3A%22Spies%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Erika%22%2C%22lastName%22%3A%22Schulte%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joerg%20J.%22%2C%22lastName%22%3A%22Meerpohl%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christine%22%2C%22lastName%22%3A%22Schmucker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edris%22%2C%22lastName%22%3A%22Nury%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dirk%22%2C%22lastName%22%3A%22Brockmann%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Wind%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Eva%22%2C%22lastName%22%3A%22Goebel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wolf-Dieter%22%2C%22lastName%22%3A%22Ludwig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ralph%22%2C%22lastName%22%3A%22Hertwig%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20The%20US%20opioid%20crisis%20and%20increasing%20prescription%20rates%20in%20Europe%20suggest%20inappropriate%20risk%20perceptions%20and%20behaviours%20of%20people%20who%20prescribe%2C%20take%20or%20advise%20on%20opioids%3A%20physicians%2C%20patients%20and%20pharmacists.%20Findings%20from%20cognitive%20and%20decision%20science%20in%20areas%20other%20than%20drug%20safety%20suggest%20that%20people%26%23039%3Bs%20risk%20perception%20and%20behaviour%20can%20differ%20depending%20on%20whether%20they%20learnt%20about%20a%20risk%20through%20personal%20experience%20or%20description.%20Experiencing%20the%20risk%20of%20overutilising%20opioids%20among%20patients%20with%20chronic%20non-cancer%20pain%20in%20ambulatory%20care%20%28ERONA%29%20is%20the%20first-ever%20conducted%20trial%20that%20aims%20at%20investigating%20the%20effects%20of%20these%20two%20modes%20of%20learning%20on%20individuals%26%23039%3B%20risk%20perception%20and%20behaviour%20in%20the%20long-term%20administration%20of%20WHO-III%20opioids%20in%20chronic%20non-cancer%20pain.%5CnMETHODS%20AND%20ANALYSIS%3A%20ERONA-an%20exploratory%2C%20randomised%20controlled%20online%20survey%20intervention%20trial%20with%20two%20parallel%20arms-will%20examine%20the%20opioid-associated%20risk%20perception%20and%20behaviour%20of%20four%20groups%20involved%20in%20the%20long-term%20administration%20of%20WHO-III%20opioids%3A%20%281%29%20family%20physicians%2C%20%282%29%20physicians%20specialised%20in%20pain%20therapy%2C%20%283%29%20patients%20with%20chronic%20%28%5Cu22653%20months%29%20non-cancer%20pain%20and%20%284%29%20pharmacists%20who%20regularly%20dispense%20narcotic%20substances.%20Participants%20will%20be%20randomly%20assigned%20to%20one%20of%20two%20online%20risk%20education%20interventions%2C%20description%20based%20or%20experiencebased.%20Both%20interventions%20will%20present%20the%20best%20medical%20evidence%20available.%20Participants%20will%20be%20queried%20at%20baseline%20and%20after%20intervention%20on%20their%20risk%20perception%20of%20opioids%26%23039%3B%20benefit-harm%20ratio%2C%20their%20medical%20risk%20literacy%20and%20their%20current%5C%2Fintended%20risk%20behaviour%20%28in%20terms%20of%20prescribing%2C%20taking%20or%20counselling%2C%20depending%20on%20study%20group%29.%20A%20follow-up%20will%20occur%20after%209%20months%2C%20when%20participants%20will%20be%20queried%20on%20their%20actual%20risk%20behaviour.%20The%20study%20was%20developed%20by%20the%20authors%20and%20will%20be%20conducted%20by%20the%20market%20research%20institution%20IPSOS%20Health.%5CnETHICS%20AND%20DISSEMINATION%3A%20The%20study%20was%20approved%20by%20the%20Institutional%20Review%20Board%20of%20the%20Max%20Planck%20Institute%20for%20Human%20Development.%20Results%20will%20be%20disseminated%20through%20peer-reviewed%20journals%2C%20conference%20presentations%20and%20social%20media.%5CnTRIAL%20REGISTRATION%20NUMBER%3A%20DRKS00020358.%22%2C%22date%22%3A%222020-09-06%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1136%5C%2Fbmjopen-2020-037642%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222044-6055%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22R2J5Y2I9%22%2C%22X7PUUBWP%22%2C%22SPWXRLZV%22%2C%22QXIGN3AI%22%2C%22GQCXJHEH%22%2C%22W637CI9M%22%2C%228B2HH96K%22%2C%22XSMILFVY%22%2C%22YT56KJXE%22%5D%2C%22dateModified%22%3A%222024-06-01T19%3A19%3A35Z%22%7D%7D%2C%7B%22key%22%3A%22CZMDVRWG%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Gerlach%20et%20al.%22%2C%22parsedDate%22%3A%222020-09-04%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGerlach%2C%20Navina%2C%20Matthias%20Michiels-Corsten%2C%20Annika%20Viniol%2C%20Tanja%20Schleef%2C%20Ulrike%20Junius-Walker%2C%20Olaf%20Krause%2C%20and%20Norbert%20Donner-Banzhoff.%20%26quot%3B%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12875-020-01255-1%26%23039%3B%26gt%3BProfessional%20roles%20of%20general%20practitioners%2C%20community%20pharmacists%20and%20specialist%20providers%20in%20collaborative%20medication%20deprescribing%20-%20a%20qualitative%20study%26lt%3B%5C%2Fa%26gt%3B.%26quot%3B%20%26lt%3Bi%26gt%3BBMC%20Family%20Practice%26lt%3B%5C%2Fi%26gt%3B%2021%2C%20no.%201%20%28September%204%2C%202020%29%3A%20183.%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Professional%20roles%20of%20general%20practitioners%2C%20community%20pharmacists%20and%20specialist%20providers%20in%20collaborative%20medication%20deprescribing%20-%20a%20qualitative%20study%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Navina%22%2C%22lastName%22%3A%22Gerlach%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Michiels-Corsten%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annika%22%2C%22lastName%22%3A%22Viniol%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tanja%22%2C%22lastName%22%3A%22Schleef%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ulrike%22%2C%22lastName%22%3A%22Junius-Walker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Olaf%22%2C%22lastName%22%3A%22Krause%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%5D%2C%22abstractNote%22%3A%22Collaborative%20care%20approaches%20between%20general%20practitioners%20%28GPs%29%20and%20pharmacists%20have%20received%20international%20recognition%20for%20medication%20optimization%20and%20deprescribing%20efforts.%20Although%20specialist%20providers%20have%20been%20shown%20to%20influence%20deprescribing%2C%20their%20profession%20so%20far%20remains%20omitted%20from%20collaborative%20care%20approaches%20for%20medication%20optimization.%20Similarly%2C%20while%20explorative%20studies%20on%20role%20perception%20and%20collaboration%20between%20GPs%20and%20pharmacists%20grow%2C%20interaction%20with%20specialists%20for%20medication%20optimization%20is%20neglected.%20Our%20qualitative%20study%20therefore%20aims%20to%20explore%20GPs%5Cu2019%2C%20community%20pharmacists%5Cu2019%20and%20specialist%20providers%5Cu2019%20role%20perceptions%20of%20deprescribing%2C%20and%20to%20identify%20interpersonal%20as%20well%20as%20structural%20factors%20that%20may%20influence%20collaborative%20medication%20optimization%20approaches.%22%2C%22date%22%3A%22September%204%2C%202020%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12875-020-01255-1%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12875-020-01255-1%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221471-2296%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22R2J5Y2I9%22%2C%22X7PUUBWP%22%2C%22SPWXRLZV%22%2C%22GQCXJHEH%22%5D%2C%22dateModified%22%3A%222024-05-14T15%3A14%3A30Z%22%7D%7D%2C%7B%22key%22%3A%22UQX4X736%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Michiels-Corsten%20et%20al.%22%2C%22parsedDate%22%3A%222020-07%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BMichiels-Corsten%2C%20Matthias%2C%20Navina%20Gerlach%2C%20Tanja%20Schleef%2C%20Ulrike%20Junius-Walker%2C%20Norbert%20Donner-Banzhoff%2C%20and%20Annika%20Viniol.%20%26%23x201C%3BGeneric%20Instruments%20for%20Drug%20Discontinuation%20in%20Primary%20Care%3A%20A%20Systematic%20Review.%26%23x201D%3B%20%26lt%3Bi%26gt%3BBritish%20Journal%20of%20Clinical%20Pharmacology%26lt%3B%5C%2Fi%26gt%3B%2086%2C%20no.%207%20%28July%202020%29%3A%201251%26%23x2013%3B66.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fbcp.14287%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fbcp.14287%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Generic%20instruments%20for%20drug%20discontinuation%20in%20primary%20care%3A%20A%20systematic%20review%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Michiels-Corsten%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Navina%22%2C%22lastName%22%3A%22Gerlach%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tanja%22%2C%22lastName%22%3A%22Schleef%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ulrike%22%2C%22lastName%22%3A%22Junius-Walker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annika%22%2C%22lastName%22%3A%22Viniol%22%7D%5D%2C%22abstractNote%22%3A%22AIMS%3A%20The%20aim%20of%20this%20systematic%20review%20was%20to%20identify%20generic%20instruments%20for%20drug%20discontinuation%20in%20patients%20with%20polypharmacy%20in%20the%20primary%20care%20setting.%5CnMETHODS%3A%20We%20systematically%20searched%20PubMed%20and%20EMBASE%2C%208%20guideline%20databases%20%28AWMF%2C%20NICE%2C%20NGC%2C%20SIGN%2C%20NHMRC%2C%20CPG%2C%20KCE%29%2C%20the%20Cochrane%20Library%20and%20grey%20literature%20%28Google%29%20in%202016%20and%202017.%20Two%20independent%20researchers%20screened%20and%20analysed%20data.%20The%20drug%20discontinuation%20instruments%20of%20the%20included%20publications%20were%20described%20and%20classified.%5CnRESULTS%3A%20We%20identified%2016%20relevant%20publications.%20Here%20we%20found%20complex%20algorithms%20as%20well%20as%20instruments%20composed%20of%20distinct%20sequential%20steps.%20Two%20guidelines%20are%20constructed%20as%20electronic%20web-applications.%20Instruments%20revealed%20diverging%20emphases%20on%20the%20stages%20of%20deprescribing%2C%20i.e.%20preparation%2C%20drug%20evaluation%2C%20decision-making%20and%20implementation.%20Accordingly%2C%203%20types%20of%20instruments%20emerged%3A%20general%20frameworks%2C%20detailed%20drug%20assessment%20tools%20and%20comprehensive%20discontinuation%20guidelines.%5CnCONCLUSION%3A%20Diverse%20generic%20instruments%20exist%20for%20different%20areas%20of%20applications%20in%20regard%20to%20drug%20discontinuation.%20However%2C%20there%20is%20still%20a%20need%20for%20practical%20and%20user-friendly%20tools%20that%20support%20physicians%20in%20communicational%20aspects%2C%20visualise%20trade-offs%20and%20also%20enhance%20patient%20involvement.%22%2C%22date%22%3A%222020-07%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1111%5C%2Fbcp.14287%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221365-2125%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22R2J5Y2I9%22%2C%22X7PUUBWP%22%2C%22SPWXRLZV%22%2C%22QXIGN3AI%22%2C%22NDCUTGYH%22%2C%22YT56KJXE%22%2C%22ACPQBWRE%22%5D%2C%22dateModified%22%3A%222025-05-18T07%3A55%3A32Z%22%7D%7D%2C%7B%22key%22%3A%22KLQCVGBQ%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Donner-Banzhoff%20et%20al.%22%2C%22parsedDate%22%3A%222020-06-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BDonner-Banzhoff%2C%20Norbert%2C%20Beate%20M%5Cu00fcller%2C%20Martin%20Beyer%2C%20J%5Cu00f6rg%20Haasenritter%2C%20and%20Carola%20Seifart.%20%26quot%3B%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fwww.degruyter.com%5C%2Fdocument%5C%2Fdoi%5C%2F10.1515%5C%2Fdx-2019-0025%5C%2Fhtml%26%23039%3B%26gt%3BThresholds%2C%20rules%20and%20defensive%20strategies%3A%20how%20physicians%20learn%20from%20their%20prior%20diagnosis-related%20experiences%26lt%3B%5C%2Fa%26gt%3B.%26quot%3B%20%26lt%3Bi%26gt%3BDiagnosis%26lt%3B%5C%2Fi%26gt%3B%207%2C%20no.%202%20%28June%201%2C%202020%29%3A%20115%5Cu201321.%20https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1515%5C%2Fdx-2019-0025.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Thresholds%2C%20rules%20and%20defensive%20strategies%3A%20how%20physicians%20learn%20from%20their%20prior%20diagnosis-related%20experiences%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beate%22%2C%22lastName%22%3A%22M%5Cu00fcller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martin%22%2C%22lastName%22%3A%22Beyer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00f6rg%22%2C%22lastName%22%3A%22Haasenritter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carola%22%2C%22lastName%22%3A%22Seifart%22%7D%5D%2C%22abstractNote%22%3A%22Background%20Health%20professionals%20are%20encouraged%20to%20learn%20from%20their%20errors.%20Determining%20how%20primary%20care%20physicians%20%28PCPs%29%20react%20to%20a%20case%2C%20in%20which%20their%20original%20diagnosis%20differed%20from%20the%20final%20outcome%2C%20could%20provide%20new%20insights%20on%20how%20they%20learn%20from%20experiences.%20We%20explored%20how%20PCPs%20altered%20their%20diagnostic%20evaluation%20of%20future%20patients%20after%20cases%20where%20the%20originally%20assumed%20diagnosis%20turned%20out%20to%20be%20wrong.%20Methods%20We%20asked%20German%20PCPs%20to%20complete%20an%20online%20survey%20where%20they%20described%20how%20the%20patient%20concerned%20originally%20presented%2C%20the%20subsequent%20course%20of%20events%20and%20whether%20they%20would%20change%20their%20diagnostic%20work-up%20of%20future%20patients.%20Qualitative%20methods%20were%20used%20to%20analyze%20narrative%20text%20obtained%20by%20this%20survey.%20Results%20A%20total%20of%2029%20PCPs%20submitted%20cases%2C%20most%20of%20which%20were%20ultimately%20found%20to%20be%20more%20severe%20than%20originally%20assumed.%20PCPs%20%28n%5Cu2009%3D%5Cu200927%29%20reflected%20on%20changes%20to%20their%20subsequent%20clinical%20decisions%20in%20the%20form%20of%20general%20maxims%20%28n%5Cu2009%3D%5Cu200920%29%20or%20more%20specific%20rules%20%28n%5Cu2009%3D%5Cu200911%29.%20Most%20changes%20would%20have%20resulted%20in%20a%20lower%20threshold%20for%20investigations%2C%20referral%20and%5C%2For%20a%20more%20extensive%20collection%20of%20diagnostic%20information.%20PCPs%20decided%20not%20only%20to%20listen%20more%20often%20to%20their%20intuition%20%28gut%20feelings%29%2C%20but%20to%20also%20practice%20more%20analytical%20reasoning.%20Participants%20felt%20the%20need%20for%20change%20of%20practice%20even%20if%20no%20clinical%20standards%20had%20been%20violated%20in%20the%20diagnosis%20of%20that%20case.%20Some%20decided%20to%20resort%20to%20defensive%20strategies%20in%20the%20future.%20Conclusions%20We%20describe%20mechanisms%20by%20which%20physicians%20calibrate%20their%20decision%20thresholds%2C%20as%20well%20as%20their%20cognitive%20mode%20%28intuitive%20vs.%20analytical%29.%20PCPs%20reported%20the%20need%20for%20change%20in%20clinical%20practice%20despite%20the%20absence%20of%20error%20in%20some%20cases.%22%2C%22date%22%3A%222020-06-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1515%5C%2Fdx-2019-0025%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.degruyter.com%5C%2Fdocument%5C%2Fdoi%5C%2F10.1515%5C%2Fdx-2019-0025%5C%2Fhtml%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222194-802X%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%22ZFT52UPQ%22%2C%2246NNKHWR%22%2C%22LSGM8V2E%22%2C%22R2J5Y2I9%22%2C%22SPWXRLZV%22%2C%22H4ES3HAF%22%2C%22QXIGN3AI%22%5D%2C%22dateModified%22%3A%222024-05-15T09%3A25%3A29Z%22%7D%7D%2C%7B%22key%22%3A%22GN799BSB%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Donner-Banzhoff%22%2C%22parsedDate%22%3A%222020-05-01%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BDonner-Banzhoff%2C%20Norbert.%20%26quot%3B%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03130-x%26%23039%3B%26gt%3BMechanistische%20Narrative%20als%20Mittel%20der%20Dissemination%3A%20das%20Beispiel%20koronarer%20Technologien%26lt%3B%5C%2Fa%26gt%3B.%26quot%3B%20%26lt%3Bi%26gt%3BBundesgesundheitsblatt%20-%20Gesundheitsforschung%20-%20Gesundheitsschutz%26lt%3B%5C%2Fi%26gt%3B%2063%2C%20no.%205%20%28May%201%2C%202020%29%3A%20521%5Cu201326.%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Mechanistische%20Narrative%20als%20Mittel%20der%20Dissemination%3A%20das%20Beispiel%20koronarer%20Technologien%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%5D%2C%22abstractNote%22%3A%22Viele%20medizinische%20Technologien%20kommen%20gro%5Cu00dffl%5Cu00e4chig%20zum%20Einsatz%2C%20obwohl%20%20empirische%20Belege%20zur%20Wirksamkeit%20und%20Sicherheit%20fehlen.%20Beispielsweise%20werden%20perkutane%20koronare%20Interventionen%20%28PCI%29%20h%5Cu00e4ufig%20bei%20der%20chronisch%20stabilen%20koronaren%20Herzerkrankung%20%28KHK%29%20eingesetzt%2C%20ohne%20dass%20daf%5Cu00fcr%20ausreichend%20Studienevidenz%20vorliegt.%20Diese%20Situation%20wirft%20die%20Frage%20auf%2C%20auf%20welcher%20Basis%20diese%20Technologien%20verbreitet%20und%20von%20den%20Menschen%20akzeptiert%20werden.%22%2C%22date%22%3A%222020-05-01%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00103-020-03130-x%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00103-020-03130-x%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221437-1588%22%2C%22language%22%3A%22de%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22LSGM8V2E%22%2C%22R2J5Y2I9%22%2C%22X7PUUBWP%22%5D%2C%22dateModified%22%3A%222024-05-15T09%3A17%3A11Z%22%7D%7D%2C%7B%22key%22%3A%22NYAZ99QD%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22M%5Cu00fcller%20et%20al.%22%2C%22parsedDate%22%3A%222020-03-17%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BM%5Cu00fcller%2C%20Beate%20S.%2C%20Norbert%20Donner-Banzhoff%2C%20Martin%20Beyer%2C%20J%5Cu00f6rg%20Haasenritter%2C%20Angelina%20M%5Cu00fcller%2C%20and%20Carola%20Seifart.%20%26quot%3B%26lt%3Ba%20class%3D%26%23039%3Bzp-ItemURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12875-020-01125-w%26%23039%3B%26gt%3BRegret%20among%20primary%20care%20physicians%3A%20a%20survey%20of%20diagnostic%20decisions%26lt%3B%5C%2Fa%26gt%3B.%26quot%3B%20%26lt%3Bi%26gt%3BBMC%20Family%20Practice%26lt%3B%5C%2Fi%26gt%3B%2021%2C%20no.%201%20%28March%2017%2C%202020%29%3A%2053.%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Regret%20among%20primary%20care%20physicians%3A%20a%20survey%20of%20diagnostic%20decisions%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Beate%20S.%22%2C%22lastName%22%3A%22M%5Cu00fcller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Martin%22%2C%22lastName%22%3A%22Beyer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22J%5Cu00f6rg%22%2C%22lastName%22%3A%22Haasenritter%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Angelina%22%2C%22lastName%22%3A%22M%5Cu00fcller%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Carola%22%2C%22lastName%22%3A%22Seifart%22%7D%5D%2C%22abstractNote%22%3A%22Experienced%20and%20anticipated%20regret%20influence%20physicians%5Cu2019%20decision-making.%20In%20medicine%2C%20diagnostic%20decisions%20and%20diagnostic%20errors%20can%20have%20a%20severe%20impact%20on%20both%20patients%20and%20physicians.%20Little%20empirical%20research%20exists%20on%20regret%20experienced%20by%20physicians%20when%20they%20make%20diagnostic%20decisions%20in%20primary%20care%20that%20later%20prove%20inappropriate%20or%20incorrect.%20The%20aim%20of%20this%20study%20was%20to%20explore%20the%20experience%20of%20regret%20following%20diagnostic%20decisions%20in%20primary%20care.%22%2C%22date%22%3A%222020-03-17%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1186%5C%2Fs12875-020-01125-w%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1186%5C%2Fs12875-020-01125-w%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221471-2296%22%2C%22language%22%3A%22en%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22R2J5Y2I9%22%2C%22X7PUUBWP%22%2C%22SPWXRLZV%22%2C%22H4ES3HAF%22%2C%22QXIGN3AI%22%5D%2C%22dateModified%22%3A%222024-03-13T08%3A48%3A33Z%22%7D%7D%2C%7B%22key%22%3A%22VC2M7ALX%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Dinh%20et%20al.%22%2C%22parsedDate%22%3A%222020%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BDinh%2C%20Truc%20Sophia%2C%20Ana%20Isabel%20Gonz%26%23xE1%3Blez-Gonz%26%23xE1%3Blez%2C%20Andreas%20D.%20Meid%2C%20Kym%20I.%20E.%20Snell%2C%20Henrik%20Rudolf%2C%20Maria-Sophie%20Brueckle%2C%20Jeanet%20W.%20Blom%2C%20et%20al.%20%26%23x201C%3BAre%20Anticholinergic%20Symptoms%20a%20Risk%20Factor%20for%20Falls%20in%20Older%20General%20Practice%20Patients%20With%20Polypharmacy%3F%20Study%20Protocol%20for%20the%20Development%20and%20Validation%20of%20a%20Prognostic%20Model.%26%23x201D%3B%20%26lt%3Bi%26gt%3BFrontiers%20in%20Pharmacology%26lt%3B%5C%2Fi%26gt%3B%2011%20%282020%29%3A%20577747.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffphar.2020.577747%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3389%5C%2Ffphar.2020.577747%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Are%20Anticholinergic%20Symptoms%20a%20Risk%20Factor%20for%20Falls%20in%20Older%20General%20Practice%20Patients%20With%20Polypharmacy%3F%20Study%20Protocol%20for%20the%20Development%20and%20Validation%20of%20a%20Prognostic%20Model%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Truc%20Sophia%22%2C%22lastName%22%3A%22Dinh%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ana%20Isabel%22%2C%22lastName%22%3A%22Gonz%5Cu00e1lez-Gonz%5Cu00e1lez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreas%20D.%22%2C%22lastName%22%3A%22Meid%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kym%20I.%20E.%22%2C%22lastName%22%3A%22Snell%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henrik%22%2C%22lastName%22%3A%22Rudolf%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria-Sophie%22%2C%22lastName%22%3A%22Brueckle%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jeanet%20W.%22%2C%22lastName%22%3A%22Blom%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ulrich%22%2C%22lastName%22%3A%22Thiem%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hans-Joachim%22%2C%22lastName%22%3A%22Trampisch%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Petra%20J.%20M.%22%2C%22lastName%22%3A%22Elders%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ferdinand%20M.%22%2C%22lastName%22%3A%22Gerlach%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sebastian%22%2C%22lastName%22%3A%22Harder%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marjan%22%2C%22lastName%22%3A%22van%20den%20Akker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Paul%20P.%22%2C%22lastName%22%3A%22Glasziou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Walter%20E.%22%2C%22lastName%22%3A%22Haefeli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christiane%22%2C%22lastName%22%3A%22Muth%22%7D%5D%2C%22abstractNote%22%3A%22Background%3A%20Cumulative%20anticholinergic%20exposure%2C%20also%20known%20as%20anticholinergic%20burden%2C%20is%20associated%20with%20a%20variety%20of%20adverse%20outcomes.%20However%2C%20studies%20show%20that%20anticholinergic%20effects%20tend%20to%20be%20underestimated%20by%20prescribers%2C%20and%20anticholinergics%20are%20the%20most%20frequently%20prescribed%20potentially%20inappropriate%20medication%20in%20older%20patients.%20The%20grading%20systems%20and%20drugs%20included%20in%20existing%20scales%20to%20quantify%20anticholinergic%20burden%20differ%20considerably%20and%20do%20not%20adequately%20account%20for%20patients%26%23039%3B%20susceptibility%20to%20medications.%20Furthermore%2C%20their%20ability%20to%20link%20anticholinergic%20burden%20with%20adverse%20outcomes%20such%20as%20falls%20is%20unclear.%20This%20study%20aims%20to%20develop%20a%20prognostic%20model%20that%20predicts%20falls%20in%20older%20general%20practice%20patients%2C%20to%20assess%20the%20performance%20of%20several%20anticholinergic%20burden%20scales%2C%20and%20to%20quantify%20the%20added%20predictive%20value%20of%20anticholinergic%20symptoms%20in%20this%20context.%20Methods%3A%20Data%20from%20two%20cluster-randomized%20controlled%20trials%20investigating%20medication%20optimization%20in%20older%20general%20practice%20patients%20in%20Germany%20will%20be%20used.%20One%20trial%20%28RIME%2C%20n%20%3D%201%2C197%29%20will%20be%20used%20for%20the%20model%20development%20and%20the%20other%20trial%20%28PRIMUM%2C%20n%20%3D%20502%29%20will%20be%20used%20to%20externally%20validate%20the%20model.%20A%20priori%2C%20candidate%20predictors%20will%20be%20selected%20based%20on%20a%20literature%20search%2C%20predictor%20availability%2C%20and%20clinical%20reasoning.%20Candidate%20predictors%20will%20include%20socio-demographics%20%28e.g.%20age%2C%20sex%29%2C%20morbidity%20%28e.g.%20single%20conditions%29%2C%20medication%20%28e.g.%20polypharmacy%2C%20anticholinergic%20burden%20as%20defined%20by%20scales%29%2C%20and%20well-being%20%28e.g.%20quality%20of%20life%2C%20physical%20function%29.%20A%20prognostic%20model%20including%20sociodemographic%20and%20lifestyle-related%20factors%2C%20as%20well%20as%20variables%20on%20morbidity%2C%20medication%2C%20health%20status%2C%20and%20well-being%2C%20will%20be%20developed%2C%20whereby%20the%20prognostic%20value%20of%20extending%20the%20model%20to%20include%20additional%20patient-reported%20symptoms%20will%20be%20also%20assessed.%20Logistic%20regression%20will%20be%20used%20for%20the%20binary%20outcome%2C%20which%20will%20be%20defined%20as%20%26quot%3Bno%20falls%26quot%3B%20vs.%20%26quot%3B%5Cu22651%20fall%26quot%3B%20within%20six%20months%20of%20baseline%2C%20as%20reported%20in%20patient%20interviews.%20Discussion%3A%20As%20the%20ability%20of%20different%20anticholinergic%20burden%20scales%20to%20predict%20falls%20in%20older%20patients%20is%20unclear%2C%20this%20study%20may%20provide%20insights%20into%20their%20relative%20importance%20as%20well%20as%20into%20the%20overall%20contribution%20of%20anticholinergic%20symptoms%20and%20other%20patient%20characteristics.%20The%20results%20may%20support%20general%20practitioners%20in%20their%20clinical%20decision-making%20and%20in%20prescribing%20fewer%20medications%20with%20anticholinergic%20properties.%22%2C%22date%22%3A%222020%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.3389%5C%2Ffphar.2020.577747%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221663-9812%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22R2J5Y2I9%22%2C%22X7PUUBWP%22%2C%22P9CVNWVH%22%2C%22N24UXA6K%22%5D%2C%22dateModified%22%3A%222024-06-05T08%3A52%3A21Z%22%7D%7D%2C%7B%22key%22%3A%226E9BZHKN%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Holtman%20et%20al.%22%2C%22parsedDate%22%3A%222019-10%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BHoltman%2C%20Gea%20A.%2C%20Marjolein%20Y.%20Berger%2C%20Huibert%20Burger%2C%20Jonathan%20J.%20Deeks%2C%20Norbert%20Donner-Banzhoff%2C%20Thomas%20R.%20Fanshawe%2C%20Constantinos%20Koshiaris%2C%20et%20al.%20%26%23x201C%3BDevelopment%20of%20Practical%20Recommendations%20for%20Diagnostic%20Accuracy%20Studies%20in%20Low-Prevalence%20Situations.%26%23x201D%3B%20%26lt%3Bi%26gt%3BJournal%20of%20Clinical%20Epidemiology%26lt%3B%5C%2Fi%26gt%3B%20114%20%28October%202019%29%3A%2038%26%23x2013%3B48.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jclinepi.2019.05.018%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.jclinepi.2019.05.018%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Development%20of%20practical%20recommendations%20for%20diagnostic%20accuracy%20studies%20in%20low-prevalence%20situations%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gea%20A.%22%2C%22lastName%22%3A%22Holtman%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marjolein%20Y.%22%2C%22lastName%22%3A%22Berger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Huibert%22%2C%22lastName%22%3A%22Burger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jonathan%20J.%22%2C%22lastName%22%3A%22Deeks%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Thomas%20R.%22%2C%22lastName%22%3A%22Fanshawe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Constantinos%22%2C%22lastName%22%3A%22Koshiaris%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mariska%20M.%22%2C%22lastName%22%3A%22Leeflang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jason%20L.%22%2C%22lastName%22%3A%22Oke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rafael%22%2C%22lastName%22%3A%22Perera%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Johannes%20B.%22%2C%22lastName%22%3A%22Reitsma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ann%22%2C%22lastName%22%3A%22Van%20den%20Bruel%22%7D%5D%2C%22abstractNote%22%3A%22OBJECTIVE%3A%20Low%20disease%20prevalence%20poses%20challenges%20for%20diagnostic%20accuracy%20studies%20because%20of%20the%20large%20sample%20sizes%20that%20are%20required%20to%20obtain%20sufficient%20precision.%20The%20aim%20is%20to%20collate%20and%20discuss%20designs%20of%20diagnostic%20accuracy%20studies%20suited%20for%20use%20in%20low-prevalence%20situations.%5CnSTUDY%20DESIGN%20AND%20SETTING%3A%20We%20conducted%20a%20literature%20search%20including%20backward%20citation%20tracking%20and%20expert%20consultation.%20Two%20reviewers%20independently%20selected%20studies%20on%20designs%20for%20estimating%20diagnostic%20accuracy%20in%20a%20low-prevalence%20situation.%20During%20a%201-day%20expert%20meeting%2C%20all%20designs%20were%20discussed%20and%20recommendations%20were%20formulated.%5CnRESULTS%3A%20We%20identified%20six%20designs%20for%20diagnostic%20accuracy%20studies%20that%20are%20suitable%20in%20low-prevalence%20situations%20because%20they%20reduced%20the%20total%20sample%20size%20or%20the%20number%20of%20patients%20undergoing%20the%20index%20test%20or%20reference%20standard%20depending%20on%20which%20poses%20the%20highest%20burden.%20We%20described%20the%20advantages%20and%20limitations%20of%20these%20designs%20and%20evaluated%20efficiencies%20in%20sample%20sizes%2C%20risk%20of%20bias%2C%20and%20alignment%20with%20the%20clinical%20pathway%20for%20applicability%20in%20routine%20care.%5CnCONCLUSION%3A%20Choosing%20a%20study%20design%20for%20diagnostic%20accuracy%20studies%20in%20low-prevalence%20situations%20should%20depend%20on%20whether%20the%20aim%20is%20to%20limit%20the%20number%20of%20patients%20undergoing%20the%20index%20test%20or%20reference%20standard%2C%20and%20the%20risk%20of%20bias%20associated%20with%20a%20particular%20design%20type.%22%2C%22date%22%3A%222019-10%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.jclinepi.2019.05.018%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221878-5921%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22R2J5Y2I9%22%2C%22X7PUUBWP%22%2C%22SPWXRLZV%22%2C%224KVK6YUS%22%5D%2C%22dateModified%22%3A%222024-03-11T09%3A24%3A08Z%22%7D%7D%2C%7B%22key%22%3A%22SQUPK95E%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Donner-Banzhoff%22%2C%22parsedDate%22%3A%222019-08%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BDonner-Banzhoff%2C%20Norbert.%20%26%23x201C%3BZwischen%20Pr%26%23xE4%3Bzisionsmedizin%20und%20symbolischer%20Bew%26%23xE4%3Bltigung%3A%20Was%20%26%23xC4%3Brzte%20w%26%23xFC%3Bnschen.%26%23x201D%3B%20%26lt%3Bi%26gt%3BZeitschrift%20Fur%20Evidenz%2C%20Fortbildung%20Und%20Qualitat%20Im%20Gesundheitswesen%26lt%3B%5C%2Fi%26gt%3B%20144%26%23x2013%3B145%20%28August%202019%29%3A%2073%26%23x2013%3B77.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.zefq.2019.05.007%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.zefq.2019.05.007%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Zwischen%20Pr%5Cu00e4zisionsmedizin%20und%20symbolischer%20Bew%5Cu00e4ltigung%3A%20Was%20%5Cu00c4rzte%20w%5Cu00fcnschen%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%5D%2C%22abstractNote%22%3A%22INTRODUCTION%3A%20Caring%20for%20patients%20is%20inevitably%20fraught%20with%20uncertainties.%20These%20may%20result%20from%20clinicians%20not%20having%20or%20not%20using%20the%20available%20knowledge%2C%20from%20the%20incompleteness%20of%20the%20medical%20science%20base%20as%20a%20whole%2C%20or%20from%20the%20inevitable%20randomness%20of%20biological%2C%20psychological%20and%20social%20phenomena.%20Advances%20in%20science%20promise%20to%20reduce%20uncertainty%20by%20making%20ever%20more%20precise%20diagnosis%20and%20treatment%20possible.%5CnMETHODS%3A%20Here%2C%20we%20discuss%20two%20typical%20examples%20of%20scientific%20progress%20and%20on%20how%20they%20impact%20on%20clinical%20uncertainty%3A%20first%2C%20the%20stratification%20of%20chemotherapy%20for%20early%20breast%20cancer%20by%20a%2070-gene%20signature%2C%20and%20second%2C%20the%20interpretation%20of%20knee%20MRI%20regarding%20meniscal%20damage.%5CnRESULTS%3A%20According%20to%20a%20large%20randomized%20trial%2C%20the%2070-gene%20-signature%20successfully%20differentiates%20between%20strata%20for%20invasive%20treatments.%20The%20quantitative%20results%20and%20related%20trade-offs%2C%20however%2C%20pose%20considerable%20difficulties%20for%20patient%20information%20and%20shared%20decision-making%2C%20thus%20increasing%20uncertainty.%20Knee%20complaints%20are%20only%20weakly%20associated%20with%20MRI%20findings.%20Pathological%20findings%20are%20highly%20prevalent%20in%20symptom-free%20individuals.%5CnCONCLUSION%3A%20Recent%20advances%20in%20diagnostic%20methods%20increase%20the%20cognitive%20demands%20on%20clinicians%20and%20thus%20their%20uncertainty.%20By%20uncritically%20using%20advanced%20technologies%20in%20their%20practice%2C%20physicians%20exploit%20their%20archetypical%20healing%20powers.%20In%20a%20paradoxical%20way%2C%20modern%20technologies%20reduce%20uncertainties%20felt%20by%20doctors%20and%20their%20patients%20in%20an%20archaic%20fashion.%22%2C%22date%22%3A%22Aug%202019%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.zefq.2019.05.007%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%222212-0289%22%2C%22language%22%3A%22ger%22%2C%22collections%22%3A%5B%227NLACL24%22%2C%22ZFT52UPQ%22%2C%2246NNKHWR%22%2C%22R2J5Y2I9%22%2C%22SPWXRLZV%22%2C%22SG8SD8IJ%22%2C%22QXIGN3AI%22%2C%22W637CI9M%22%2C%22P9CVNWVH%22%5D%2C%22dateModified%22%3A%222024-05-15T14%3A32%3A54Z%22%7D%7D%2C%7B%22key%22%3A%22NJ87EMNI%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Semjonow%20et%20al.%22%2C%22parsedDate%22%3A%222019-07%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BSemjonow%2C%20Axel%2C%20Hans-Werner%20Hense%2C%20Kathrin%20Schl%26%23xF6%3B%26%23xDF%3Bler%2C%20Alexandra%20Simbrich%2C%20Matthias%20Borowski%2C%20Christiane%20Bothe%2C%20Klaus%20Kruse%2C%20et%20al.%20%26%23x201C%3BDevelopment%20and%20Prospective%20Randomized%20Evaluation%20of%20a%20Decision%20Aid%20for%20Prostate-Specific%20Antigen-Based%20Early%20Detection%20of%20Prostate%20Cancer%20in%20Men%20Aged%20Between%2055%20and%2069Yr%3A%20The%20PSAInForm%20Trial.%26%23x201D%3B%20%26lt%3Bi%26gt%3BEuropean%20Urology%26lt%3B%5C%2Fi%26gt%3B%2076%2C%20no.%201%20%28July%202019%29%3A%201%26%23x2013%3B3.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.eururo.2019.01.008%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.eururo.2019.01.008%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Development%20and%20Prospective%20Randomized%20Evaluation%20of%20a%20Decision%20Aid%20for%20Prostate-specific%20Antigen-based%20Early%20Detection%20of%20Prostate%20Cancer%20in%20Men%20Aged%20Between%2055%20and%2069Yr%3A%20The%20PSAInForm%20Trial%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Axel%22%2C%22lastName%22%3A%22Semjonow%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hans-Werner%22%2C%22lastName%22%3A%22Hense%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22Schl%5Cu00f6%5Cu00dfler%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alexandra%22%2C%22lastName%22%3A%22Simbrich%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Matthias%22%2C%22lastName%22%3A%22Borowski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christiane%22%2C%22lastName%22%3A%22Bothe%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Klaus%22%2C%22lastName%22%3A%22Kruse%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Dorothee%22%2C%22lastName%22%3A%22Tiedje%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kathrin%22%2C%22lastName%22%3A%22Kuss%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Charles%20Christian%22%2C%22lastName%22%3A%22Adarkwah%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Peter%22%2C%22lastName%22%3A%22Maisel%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ralf%22%2C%22lastName%22%3A%22Jendyk%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Marc-Andr%5Cu00e9%22%2C%22lastName%22%3A%22Kurosinski%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Joachim%22%2C%22lastName%22%3A%22Ger%5Cu00df%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Oliver%22%2C%22lastName%22%3A%22Heidinger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Christian%22%2C%22lastName%22%3A%22Tschuschke%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ralf%22%2C%22lastName%22%3A%22Becker%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Monique%20J.%22%2C%22lastName%22%3A%22Roobol%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chris%22%2C%22lastName%22%3A%22Bangma%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%5D%2C%22abstractNote%22%3A%22For%20men%20interested%20in%20early%20detection%20of%20prostate%20cancer%2C%20the%20potential%20impact%20on%20decisional%20conflict%20of%20a%20decision%20aid%20with%20or%20without%20cost%20compensation%20for%20the%20prostate-specific%20antigen%20test%20will%20be%20investigated.%22%2C%22date%22%3A%222019-07%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.eururo.2019.01.008%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221873-7560%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22R2J5Y2I9%22%5D%2C%22dateModified%22%3A%222024-03-11T09%3A23%3A44Z%22%7D%7D%2C%7B%22key%22%3A%226FQQ7BX4%22%2C%22library%22%3A%7B%22id%22%3A6298796%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Wellek%20et%20al.%22%2C%22parsedDate%22%3A%222019-06-28%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%201.35%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BWellek%2C%20Stefan%2C%20Norbert%20Donner-Banzhoff%2C%20Jochem%20K%26%23xF6%3Bnig%2C%20Philipp%20Mildenberger%2C%20and%20Maria%20Blettner.%20%26%23x201C%3BPlanning%20and%20Analysis%20of%20Trials%20Using%20a%20Stepped%20Wedge%20Design.%26%23x201D%3B%20%26lt%3Bi%26gt%3BDeutsches%20Arzteblatt%20International%26lt%3B%5C%2Fi%26gt%3B%20116%2C%20no.%2026%20%28June%2028%2C%202019%29%3A%20453%26%23x2013%3B58.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3238%5C%2Farztebl.2019.0453%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3238%5C%2Farztebl.2019.0453%26lt%3B%5C%2Fa%26gt%3B.%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Planning%20and%20Analysis%20of%20Trials%20Using%20a%20Stepped%20Wedge%20Design%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Stefan%22%2C%22lastName%22%3A%22Wellek%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Norbert%22%2C%22lastName%22%3A%22Donner-Banzhoff%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jochem%22%2C%22lastName%22%3A%22K%5Cu00f6nig%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Philipp%22%2C%22lastName%22%3A%22Mildenberger%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Maria%22%2C%22lastName%22%3A%22Blettner%22%7D%5D%2C%22abstractNote%22%3A%22BACKGROUND%3A%20The%20stepped-wedge%20design%20%28SWD%29%20of%20clinical%20trials%20has%20become%20very%20popular%20in%20recent%20years%2C%20particularly%20in%20health%20services%20research.%20Typically%2C%20study%20participants%20are%20randomly%20allotted%20in%20clusters%20to%20the%20different%20treatment%20options.%5CnMETHODS%3A%20The%20basic%20principles%20of%20the%20stepped%20wedge%20design%20and%20related%20statistical%20techniques%20are%20described%20here%20on%20the%20basis%20of%20pertinent%20publications%20retrieved%20by%20a%20selective%20search%20in%20PubMed%20and%20in%20the%20CIS%20statistical%20literature%20database.%5CnRESULTS%3A%20In%20a%20typical%20SWD%20trial%2C%20the%20intervention%20is%20begun%20at%20a%20time%20point%20that%20varies%20from%20cluster%20to%20cluster.%20Until%20this%20time%20point%20is%20reached%2C%20all%20participants%20in%20the%20cluster%20belong%20to%20the%20control%20arm%20of%20the%20trial.%20Once%20the%20intervention%20is%20begun%2C%20it%20is%20continued%20with-%20out%20change%20until%20the%20end%20of%20the%20trial%20period.%20The%20starting%20time%20for%20the%20intervention%20in%20each%20cluster%20is%20determined%20by%20randomization.%20At%20the%20first%20time%20point%20of%20measurement%2C%20no%20intervention%20has%20yet%20begun%20in%20any%20cluster%3B%20at%20the%20last%20one%2C%20the%20intervention%20is%20in%20prog-%20ress%20in%20all%20clusters.%20The%20treatment%20effect%20can%20be%20optimally%20assessed%20under%20the%20assumption%20of%20an%20identical%20correlation%20at%20all%20time%20points.%20A%20method%20is%20available%20to%20calculate%20the%20power%20and%20the%20number%20of%20clusters%20that%20would%20be%20necessary%20in%20order%20to%20achieve%20statistical%20significance%20by%20the%20appropriate%20type%20of%20significance%20test.%20All%20of%20the%20statistical%20techniques%20presented%20here%20are%20based%20on%20the%20assumptions%20of%20a%20normal%20distribution%20of%20cluster%20means%20and%20of%20a%20constant%20intervention%20effect%20across%20all%20time%20points%20of%20measure-%20ment.%5CnCONCLUSION%3A%20The%20necessary%20statistical%20tools%20for%20the%20planning%20and%20evaluation%20of%20SWD%20trials%20now%20stand%20at%20our%20disposal.%20Such%20trials%20nevertheless%20are%20subject%20to%20major%20risks%2C%20as%20valid%20results%20can%20be%20obtained%20only%20if%20the%20far-reaching%20assumptions%20of%20the%20model%20are%2C%20in%20fact%2C%20justified.%22%2C%22date%22%3A%222019-06-28%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.3238%5C%2Farztebl.2019.0453%22%2C%22citationKey%22%3A%22%22%2C%22url%22%3A%22%22%2C%22PMID%22%3A%22%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221866-0452%22%2C%22language%22%3A%22eng%22%2C%22collections%22%3A%5B%2246NNKHWR%22%2C%22R2J5Y2I9%22%2C%22X7PUUBWP%22%2C%22SPWXRLZV%22%2C%22QXIGN3AI%22%5D%2C%22dateModified%22%3A%222024-03-11T09%3A24%3A19Z%22%7D%7D%5D%7D
Lindner, Nicole, Marie-Christine Hoffmann, Jörg Haasenritter, Jan K. Woike, and Norbert Donner-Banzhoff. "Assessing physicians' agreement and the completeness of the decision aid 'arriba Diabetes': a cross-sectional study." BMC Primary Care 26, no. 1 (July 8, 2025): 218. https://doi.org/10.1186/s12875-025-02887-x.
Kornder, Nele, Norbert Donner-Banzhoff, Ina Staudt, Nina Grede, Annette Becker, and Annika Viniol. "Trials evaluating drug discontinuation: a scoping review sub-analysis focusing on outcomes and research questions." BMC Medical Research Methodology 25, no. 1 (May 27, 2025): 146. https://doi.org/10.1186/s12874-025-02597-z.
Gollnick, Julia, Nikoletta Zeschick, Franziska Hörbrand, Peter Killian, Maria Sebastiao, Thomas Kühlein, and Norbert Donner-Banzhoff. "Surveillance of drug prescribing: why outliers miss their targets – a qualitative study." BMC Health Services Research 25, no. 1 (January 3, 2025): 17.
Purkl, Laura, Konrad Hierasimowicz, and Norbert Donner-Banzhoff. “Three Types of Uncertainty: A Qualitative Study of Family Medicine Residents.” Family Medicine 57, no. 1 (January 2025): 9–15. https://doi.org/10.22454/FamMed.2024.798978.
Prinz, Alicia, Sabrina Hoppe, Verena Leve, Rik Crutzen, Norbert Donner-Banzhoff, Stefan Wilm, and Sabrina Kastaun. "Experiences, perceptions and attitudes on providing advice on physical activity to patients with chronic ischaemic heart disease: a qualitative study in general practitioners in Germany." Family Medicine and Community Health 13, no. 3 (2025): e003124. https://doi.org/10.1136/fmch-2024-003124.
Zeschick, Nikoletta, Julia Gollnick, Julia Muth, Franziska Hörbrand, Peter Killian, Norbert Donner-Banzhoff, Thomas Kühlein, and Maria Sebastião. "Prescribing Vitamin-K-Antagonists Versus Direct Oral Anticoagulants Among Bavarian General Practitioners: A Qualitative Study." Health Services Insights 18 (2025): 11786329251341083. https://doi.org/10.1177/11786329251341083.
Gollnick, Julia, Nikoletta Zeschick, Julia Muth, Franziska Hörbrand, Kerstin Behnke, Peter Killian, Maria Sebastiao, Thomas Kühlein, and Norbert Donner-Banzhoff. “Controlling Prescribing through ‘Preferred Drug’ Targets-The Bavarian Experience.” International Journal of Environmental Research and Public Health 21, no. 9 (September 3, 2024): 1174. https://doi.org/10.3390/ijerph21091174.
Jung-Henrich, Jutta, Kathrin Schlößler, Til Uebel, Nino Chikhradze, Anastasia Suslow, Nicole Lindner, Sandra Fahrenkrog, et al. “Development and Implementation of a Treatment Pathway to Reduce Coronary Angiograms - Lessons from a Failure.” BMC Health Services Research 24, no. 1 (April 25, 2024): 527. https://doi.org/10.1186/s12913-024-10904-5.
Donner-Banzhoff, Norbert. "Was zählt als Argument? Belege und Begründungen bei medizinischen Entscheidungen." Osnabrücker Beiträge zur Sprachtheorie 102, no. Sprache, Wissen, Macht. Zur sprachlichen Konstitution (bio)medizinischer und bioethischer Kommunikation (February 13, 2024). https://doi.org/10.17192/OBST.2024.102.8639.
Grede, Nina, Ulrike Trampisch, Sabine Weissbach, Monika Heinzel-Gutenbrunner, Ellen Freiberger, Andreas Sönnichsen, and Norbert Donner-Banzhoff. “A Volunteer-Supported Walking Programme to Improve Physical Function in Older People with Restricted Mobility (the POWER Study): A Randomised Controlled Trial.” BMC Geriatrics 24, no. 1 (January 15, 2024): 60. https://doi.org/10.1186/s12877-024-04672-4.
Donner-Banzhoff, Norbert, and Ferdinand Michael Gerlach. "Ein Vorschlag zur Förderung der ärztlichen Weiterbildung im Kontext einer reformierten Krankenhausfinanzierung." Das Gesundheitswesen, December 14, 2023. https://doi.org/10.1055/a-2189-2209.
Heisig, Julia, Bettina Bücker, Alexandra Schmidt, Anne-Lisa Heye, Anja Rieckert, Susanne Löscher, Oliver Hirsch, et al. “Efficacy of a Computer Based Discontinuation Strategy to Reduce PPI Prescriptions: A Multicenter Cluster-Randomized Controlled Trial.” Scientific Reports 13, no. 1 (December 7, 2023): 21633. https://doi.org/10.1038/s41598-023-48839-2.
Zeschick, Nikoletta, Julia Gollnick, Julia Muth, Franziska Hörbrand, Peter Killian, Norbert Donner-Banzhoff, Thomas Kühlein, and Maria Sebastião. "Physicians' assessment of the Bavarian drug-expenditure control system: a qualitative study." BMC Health Services Research 23 (September 7, 2023): 961. https://doi.org/10.1186/s12913-023-09844-3.
Weissbach, Sabine, Anja Rieckert, Christine Kersting, Nina Grede, Norbert Donner-Banzhoff, Andreas Soennichsen, Horst Christian Vollmar, Ina Otte, Pia Weimer, and Ulrike Sonja Trampisch. “Experiences of Participants of a Volunteer-Supported Walking Intervention to Improve Physical Function of Nursing Home Residents - a Mixed Methods Sub-Study of the POWER-Project.” BMC Geriatrics 23, no. 1 (June 1, 2023): 343. https://doi.org/10.1186/s12877-023-04044-4.
Winkler, Katja, Navina Gerlach, Norbert Donner-Banzhoff, Anika Berberich, Jutta Jung-Henrich, and Kathrin Schlößler. “Determinants of Referral for Suspected Coronary Artery Disease: A Qualitative Study Based on Decision Thresholds.” BMC Primary Care 24, no. 1 (May 2, 2023): 110. https://doi.org/10.1186/s12875-023-02064-y.
Wächtler, Hannelore, Hanna Kaduszkiewicz, Oskar Kuhnert, Karolina Agata Malottki, Sonja Maaß, Jürgen Hedderich, Birgitt Wiese, Norbert Donner-Banzhoff, and Julia Hansmann-Wiest. “Influence of a Guideline or an Additional Rapid Strep Test on Antibiotic Prescriptions for Sore Throat: The Cluster Randomized Controlled Trial of HALS (Hals Und Antibiotika Leitlinien Strategien).” BMC Primary Care 24, no. 1 (March 20, 2023): 75. https://doi.org/10.1186/s12875-023-01987-w.
Grede, Nina, Katrin Kuss, Ina Staudt, Norbert Donner-Banzhoff, and Annika Viniol. “Mapping the Methodological Diversity of Published Drug Discontinuation Studies-a Scoping Review of Study Topics, Objectives, and Designs.” Trials 24, no. 1 (January 26, 2023): 58. https://doi.org/10.1186/s13063-023-07105-6.
Flemming, Ronja, Franziska Frölich, Norbert Donner-Banzhoff, and Leonie Sundmacher. “Diffusion of a New Drug among Ambulatory Physicians-The Impact of Patient Pathways.” Health Economics, January 6, 2023. https://doi.org/10.1002/hec.4650.
Dinh, Truc Sophia, Andreas D. Meid, Henrik Rudolf, Maria-Sophie Brueckle, Ana I. González-González, Veronika Bencheva, Matthias Gogolin, et al. “Anticholinergic Burden Measures, Symptoms, and Fall-Associated Risk in Older Adults with Polypharmacy: Development and Validation of a Prognostic Model.” PloS One 18, no. 1 (2023): e0280907. https://doi.org/10.1371/journal.pone.0280907.
Wegwarth, Odette, Claudia Spies, Wolf-Dieter Ludwig, Norbert Donner-Banzhoff, Günther Jonitz, and Ralph Hertwig. “Educating Physicians on Strong Opioids by Descriptive versus Simulated-Experience Formats: A Randomized Controlled Trial.” BMC Medical Education 22, no. 1 (October 26, 2022): 741. https://doi.org/10.1186/s12909-022-03797-7.
Michiels-Corsten, Matthias, Navina Gerlach, Ulrike Junius-Walker, Tanja Schleef, Norbert Donner-Banzhoff, and Annika Viniol. “MediQuit - an Electronic Deprescribing Tool: A Pilot Study in German Primary Care; GPs’ and Patients’ Perspectives.” BMC Primary Care 23, no. 1 (September 26, 2022): 252. https://doi.org/10.1186/s12875-022-01852-2.
Novelli, Anna, Julia Frank-Tewaag, Julian Bleek, Christian Günster, Udo Schneider, Ursula Marschall, Kathrin Schlößler, Norbert Donner-Banzhoff, and Leonie Sundmacher. “Identifying and Investigating Ambulatory Care Sequences Before Invasive Coronary Angiography.” Medical Care 60, no. 8 (August 1, 2022): 602–9. https://doi.org/10.1097/MLR.0000000000001738.
Angelow, Aniela, Christine Klötzer, Norbert Donner-Banzhoff, Jörg Haasenritter, Carsten Oliver Schmidt, Marcus Dörr, and Jean-François Chenot. “Validation of Cardiovascular Risk Prediction by the Arriba Instrument.” Deutsches Arzteblatt International 119, no. 27–28 (July 11, 2022): 476–82. https://doi.org/10.3238/arztebl.m2022.0220.
Hahlweg, Pola, Christiane Bieber, Anna Levke Brütt, Marie-Luise Dierks, Jörg Dirmaier, Norbert Donner-Banzhoff, Wolfgang Eich, et al. “Moving towards Patient-Centered Care and Shared Decision-Making in Germany.” Zeitschrift Fur Evidenz, Fortbildung Und Qualitat Im Gesundheitswesen 171 (June 2022): 49–57. https://doi.org/10.1016/j.zefq.2022.04.001.
Michiels-Corsten, Matthias, Anna M. Weyand, Judith Gold, Stefan Bösner, and Norbert Donner-Banzhoff. “Inductive Foraging: Patients Taking the Lead in Diagnosis, a Mixed-Methods Study.” Family Practice 39, no. 3 (May 28, 2022): 479–85. https://doi.org/10.1093/fampra/cmab144.
Schulte, Erika, Frank Petzke, Claudia Spies, Claudia Denke, Michael Schäfer, Norbert Donner-Banzhoff, Ralph Hertwig, and Odette Wegwarth. “Self-Reported Practices and Emotions in Prescribing Opioids for Chronic Noncancer Pain: A Cross-Sectional Study of German Physicians.” Journal of Clinical Medicine 11, no. 9 (April 29, 2022): 2506. https://doi.org/10.3390/jcm11092506.
Frank-Tewaag, Julia, Julian Bleek, Christian Günster, Udo Schneider, Dirk Horenkamp-Sonntag, Ursula Marschall, Sebastian Franke, Kathrin Schlößler, Norbert Donner-Banzhoff, and Leonie Sundmacher. “Regional Variation in Coronary Angiography Rates: The Association with Supply Factors and the Role of Indication: A Spatial Analysis.” BMC Cardiovascular Disorders 22, no. 1 (February 26, 2022): 72. https://doi.org/10.1186/s12872-022-02513-z.
Zeschick, Nikoletta, Julia Gollnick, Julia Muth, Franziska Hörbrand, Peter Killian, Wolfgang Krombholz, Norbert Donner-Banzhoff, Thomas Kühlein, and Maria Sebastião. "Verordnungsverhalten von bayerischen Hausärzt*innen an der stationär-ambulanten Schnittstelle vor dem Hintergrund der Bayerischen Wirkstoffvereinbarung – Qualitative Ergebnisse der WirtMed-Studie." Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz 65, no. 9 (2022): 900–908. https://doi.org/10.1007/s00103-022-03563-6.
Schulte, Erika, Claudia Spies, Claudia Denke, Joerg J. Meerpohl, Norbert Donner-Banzhoff, Frank Petzke, Ralph Hertwig, Michael Schäfer, and Odette Wegwarth. “Patients’ Self-Reported Physical and Psychological Effects of Opioid Use in Chronic Noncancer Pain-A Retrospective Cross-Sectional Analysis.” European Journal of Pain (London, England), September 30, 2021. https://doi.org/10.1002/ejp.1868.
Viniol, Annika, Jörg Haasenritter, Nina Grede, Karl Wegscheider, Annette Becker, Helmut Sitter, Ildikó Gágyor, et al. “Typology of Drug Discontinuation Trials - Methodological Recommendations.” Journal of Clinical Epidemiology 137 (September 2021): 23–30. https://doi.org/10.1016/j.jclinepi.2021.03.017.
Kuss, Katrin, Charles Christian Adarkwah, Miriam Becker, Norbert Donner-Banzhoff, and Kathrin Schloessler. “Delivering the Unexpected-Information Needs for PSA Screening from Men’s Perspective: A Qualitative Study.” Health Expectations: An International Journal of Public Participation in Health Care and Health Policy 24, no. 4 (August 2021): 1403–12. https://doi.org/10.1111/hex.13275.
Junius-Walker, Ulrike, Annika Viniol, Matthias Michiels-Corsten, Navina Gerlach, Norbert Donner-Banzhoff, and Tanja Schleef. “MediQuit, an Electronic Deprescribing Tool for Patients on Polypharmacy: Results of a Feasibility Study in German General Practice.” Drugs & Aging 38, no. 8 (August 2021): 725–33. https://doi.org/10.1007/s40266-021-00861-7.
Maisel, Peter, Erika Baum, and Norbert Donner-Banzhoff. “Fatigue as the Chief Complaint – Epidemiology, Causes, Diagnosis, and Treatment.” Deutsches Arzteblatt International, no. Forthcoming (July 26, 2021): arztebl.m2021.0192. https://doi.org/10.3238/arztebl.m2021.0192.
Bergmann, Milena, Jörg Haasenritter, Dominik Beidatsch, Sonja Schwarm, Kaja Hörner, Stefan Bösner, Paula Grevenrath, et al. “Prevalence, Aetiologies and Prognosis of the Symptom Cough in Primary Care: A Systematic Review and Meta-Analysis.” BMC Family Practice 22, no. 1 (July 12, 2021): 151. https://doi.org/10.1186/s12875-021-01501-0.
Wehkamp, Kai, Felicia Beatrice Kiefer, Friedemann Geiger, Fueloep Scheibler, Jens Ulrich Rueffer, Norbert Donner-Banzhoff, and Cornelia Betsch. "Enhancing Specific Health Literacy with a Digital Evidence-Based Patient Decision Aid for Hypertension: A Randomized Controlled Trial." Patient Preference and Adherence 15 (June 14, 2021): 1269–79. https://doi.org/10.2147/PPA.S311470.
Bergmann, Milena, Jörg Haasenritter, Dominik Beidatsch, Sonja Schwarm, Kaja Hörner, Stefan Bösner, Paula Grevenrath, et al. “Coughing Children in Family Practice and Primary Care: A Systematic Review of Prevalence, Aetiology and Prognosis.” BMC Pediatrics 21, no. 1 (June 4, 2021): 260. https://doi.org/10.1186/s12887-021-02739-4.
Blumenthal, Sandra, Norbert Donner-Banzhoff, Uwe Popert, and Thomas Kühlein. "Zwischen Heilkunst und Kommerz: Welche Ökonomie verträgt "gute" Medizin? - Online ZFA." 02 02, no. 966 (February 2, 2021): 66–66.
Grede, Nina, Anja Rieckert, Julia Muth, Joana Steinbuck, Sabine Weissbach, Annika Schneider, Beate Weber-Schicker, et al. “A Volunteer-Supported Walking Programme to Improve Physical Function in Older People (the POWER Study): Study Protocol for a Randomised Controlled Trial.” BMC Geriatrics 21, no. 1 (January 13, 2021): 45. https://doi.org/10.1186/s12877-020-01988-9.
Frank-Tewaag, Julia, Julian Bleek, Dirk Horenkamp-Sonntag, Ursula Marschall, Uwe Zeymer, Norbert Donner-Banzhoff, and Leonie Sundmacher. “Use of Guideline-Recommended Drug Therapy in Patients Undergoing Percutaneous Coronary Intervention for Stable Coronary Heart Disease in Germany: A Multilevel Analysis of Nationwide Routine Data.” BMJ Open 10, no. 12 (December 13, 2020): e042886. https://doi.org/10.1136/bmjopen-2020-042886.
Wegwarth, Odette, Claudia Spies, Erika Schulte, Joerg J. Meerpohl, Christine Schmucker, Edris Nury, Dirk Brockmann, et al. “Experiencing the Risk of Overutilising Opioids among Patients with Chronic Non-Cancer Pain in Ambulatory Care (ERONA): The Protocol of an Exploratory, Randomised Controlled Trial.” BMJ Open 10, no. 9 (September 6, 2020): e037642. https://doi.org/10.1136/bmjopen-2020-037642.
Gerlach, Navina, Matthias Michiels-Corsten, Annika Viniol, Tanja Schleef, Ulrike Junius-Walker, Olaf Krause, and Norbert Donner-Banzhoff. "Professional roles of general practitioners, community pharmacists and specialist providers in collaborative medication deprescribing - a qualitative study." BMC Family Practice 21, no. 1 (September 4, 2020): 183.
Michiels-Corsten, Matthias, Navina Gerlach, Tanja Schleef, Ulrike Junius-Walker, Norbert Donner-Banzhoff, and Annika Viniol. “Generic Instruments for Drug Discontinuation in Primary Care: A Systematic Review.” British Journal of Clinical Pharmacology 86, no. 7 (July 2020): 1251–66. https://doi.org/10.1111/bcp.14287.
Donner-Banzhoff, Norbert, Beate Müller, Martin Beyer, Jörg Haasenritter, and Carola Seifart. "Thresholds, rules and defensive strategies: how physicians learn from their prior diagnosis-related experiences." Diagnosis 7, no. 2 (June 1, 2020): 115–21. https://doi.org/10.1515/dx-2019-0025.
Donner-Banzhoff, Norbert. "Mechanistische Narrative als Mittel der Dissemination: das Beispiel koronarer Technologien." Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 63, no. 5 (May 1, 2020): 521–26.
Müller, Beate S., Norbert Donner-Banzhoff, Martin Beyer, Jörg Haasenritter, Angelina Müller, and Carola Seifart. "Regret among primary care physicians: a survey of diagnostic decisions." BMC Family Practice 21, no. 1 (March 17, 2020): 53.
Dinh, Truc Sophia, Ana Isabel González-González, Andreas D. Meid, Kym I. E. Snell, Henrik Rudolf, Maria-Sophie Brueckle, Jeanet W. Blom, et al. “Are Anticholinergic Symptoms a Risk Factor for Falls in Older General Practice Patients With Polypharmacy? Study Protocol for the Development and Validation of a Prognostic Model.” Frontiers in Pharmacology 11 (2020): 577747. https://doi.org/10.3389/fphar.2020.577747.
Holtman, Gea A., Marjolein Y. Berger, Huibert Burger, Jonathan J. Deeks, Norbert Donner-Banzhoff, Thomas R. Fanshawe, Constantinos Koshiaris, et al. “Development of Practical Recommendations for Diagnostic Accuracy Studies in Low-Prevalence Situations.” Journal of Clinical Epidemiology 114 (October 2019): 38–48. https://doi.org/10.1016/j.jclinepi.2019.05.018.
Donner-Banzhoff, Norbert. “Zwischen Präzisionsmedizin und symbolischer Bewältigung: Was Ärzte wünschen.” Zeitschrift Fur Evidenz, Fortbildung Und Qualitat Im Gesundheitswesen 144–145 (August 2019): 73–77. https://doi.org/10.1016/j.zefq.2019.05.007.
Semjonow, Axel, Hans-Werner Hense, Kathrin Schlößler, Alexandra Simbrich, Matthias Borowski, Christiane Bothe, Klaus Kruse, et al. “Development and Prospective Randomized Evaluation of a Decision Aid for Prostate-Specific Antigen-Based Early Detection of Prostate Cancer in Men Aged Between 55 and 69Yr: The PSAInForm Trial.” European Urology 76, no. 1 (July 2019): 1–3. https://doi.org/10.1016/j.eururo.2019.01.008.
Wellek, Stefan, Norbert Donner-Banzhoff, Jochem König, Philipp Mildenberger, and Maria Blettner. “Planning and Analysis of Trials Using a Stepped Wedge Design.” Deutsches Arzteblatt International 116, no. 26 (June 28, 2019): 453–58. https://doi.org/10.3238/arztebl.2019.0453.